DRSC/TRiP Functional Genomics Resources

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Protein Alignment CASK and pals2b

DIOPT Version :9

Sequence 1:NP_001262811.1 Gene:CASK / 42567 FlyBaseID:FBgn0013759 Length:929 Species:Drosophila melanogaster
Sequence 2:XP_005170070.1 Gene:pals2b / 394134 ZFINID:ZDB-GENE-040426-775 Length:580 Species:Danio rerio


Alignment Length:595 Identity:227/595 - (38%)
Similarity:328/595 - (55%) Gaps:78/595 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly   335 DEWADEEAGIEAVQRILDCLDDIYSLQDA-HVDADVLRDMLRDNRLHQFLQLFDR---IAATVVT 395
            ||.||...   |:|::||.|.::.|...| .:|...|:.::....:....:..:|   :....|.
Zfish    33 DEGADPSG---AMQQVLDNLGELPSTTGAKDIDLIFLKGIMESPIVRSLAKAHERLEDVKLEAVQ 94

  Fly   396 SNGRAPAAEAVGRCRDVLEQLSSTSGGNSLGGKYAKEELMRLLAAPHMQALLHSHDVVARDVYGE 460
            .|.       |....|:|..:|..|..:.     :..||.::|..||.|:||.:||:||...|  
Zfish    95 ENN-------VELVTDILGDISGLSVRDD-----SAAELSKILQEPHFQSLLEAHDMVASKCY-- 145

  Fly   461 EALRVTPPPMVPYLNGDELDNVEGGELQHVTRVRLVQFQKNTDEPMGITLKMTEDGRCIVARIMH 525
            ||      |..|.|..|...|   ..|.....||::..:|...||:|:|.:| :.|..::|||:|
Zfish   146 EA------PAPPELTNDAAVN---NALMQADAVRMIGIRKKAGEPLGVTFRM-DKGDLVIARILH 200

  Fly   526 GGMIHRQATLHVGDEIREINGQPVQHQSVGQLQRMLREARGSVTFKIVPSYRSAPPPCEIFVRAQ 590
            ||:|.||..|||||.|:|:||:.|..... :||.||:|..|.:|.||:||||.||.|.:::|:..
Zfish   201 GGLIDRQGLLHVGDIIKEVNGKDVGTNPT-ELQEMLKECSGGITLKILPSYRDAPAPPQVYVKPH 264

  Fly   591 FDYNPLDDELIPCAQAGISFQVGDILQIISKDDHHWWQARLDTVGGSAGLIPSPELQEWR----- 650
            |||||..|.||||.:||::|:.||||||::::|.:|||| .....|..|||||..|:|.|     
Zfish   265 FDYNPASDNLIPCREAGLAFKRGDILQIVNREDPNWWQA-CHLAEGGTGLIPSQFLEEKRKAFVP 328

  Fly   651 -------IACQTVDKTKQEQVNCSIFGRKKKQCRDKYLAKHNAIFDTLDVVTYEEVVKVPVGDPN 708
                   |.|.|:.            |:|||:.  .||...||.||..::..||||.::    |.
Zfish   329 RDLDGAGILCGTMT------------GKKKKKM--MYLTAKNAEFDRHELQIYEEVARM----PP 375

  Fly   709 FQRKTLVLLGAHGVGRRHIKNTLISKYPDKYAYPIPHTTRPAKPEEENGRSYYFVSHDEMMADIG 773
            ||||||:|:||.|||||.:||.|:..:|.::...:|||:|..:.:|.:|:||.||:..||..||.
Zfish   376 FQRKTLILIGAQGVGRRSLKNRLVVLHPTRFGTTVPHTSRRPRNDERDGQSYRFVTRLEMETDIK 440

  Fly   774 ANEYLEYGTHEDAMYGTKLDTIRRIHTEGKMAILDVEPQALKILRTAEFTPYVVFIAAPSLQNIA 838
            ...|||:|.::..:||||:|:|..:...|:..||||.|||||:|:|.||.|||||||||....:.
Zfish   441 LGRYLEHGEYDGNLYGTKIDSIHEVVNTGRTCILDVNPQALKLLKTPEFMPYVVFIAAPEFDTLK 505

  Fly   839 DY---------------DGSLERLAKESEMLRQLYGHFFDLTIVNNDISETIATLETAIDRVHTT 888
            |.               |..|::...||..:.:.|.|:|||.|||:::......|:::::.:.|.
Zfish   506 DMHKAVVDAGLTTKQLADVDLKKTVDESARILRAYRHYFDLIIVNDNLDCAFEKLQSSVEELCTE 570

  Fly   889 PQWVPVSWLY 898
            ||||||||:|
Zfish   571 PQWVPVSWVY 580

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CASKNP_001262811.1 STKc_CASK 8..308 CDD:270996
S_TKc 12..278 CDD:214567
L27 347..396 CDD:280918 10/52 (19%)
L27 406..462 CDD:280918 18/55 (33%)
PDZ_signaling 493..573 CDD:238492 36/79 (46%)
SH3_CASK 586..646 CDD:213014 31/59 (53%)
Guanylate_kin 710..883 CDD:279019 78/187 (42%)
GuKc 720..883 CDD:214504 70/177 (40%)
pals2bXP_005170070.1 L27 43..96 CDD:197794 10/52 (19%)
L27 98..149 CDD:280918 20/63 (32%)
PDZ_signaling 169..247 CDD:238492 36/79 (46%)
SH3_MPP 260..317 CDD:212796 30/57 (53%)
Guanylate_kin 377..567 CDD:279019 78/189 (41%)
GuKc 387..568 CDD:214504 70/180 (39%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C170594300
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D364535at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
32.850

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