DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CASK and pals2b

DIOPT Version :10

Sequence 1:NP_001262811.1 Gene:CASK / 42567 FlyBaseID:FBgn0013759 Length:929 Species:Drosophila melanogaster
Sequence 2:XP_005170070.1 Gene:pals2b / 394134 ZFINID:ZDB-GENE-040426-775 Length:580 Species:Danio rerio


Alignment Length:595 Identity:227/595 - (38%)
Similarity:328/595 - (55%) Gaps:78/595 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly   335 DEWADEEAGIEAVQRILDCLDDIYSLQDA-HVDADVLRDMLRDNRLHQFLQLFDR---IAATVVT 395
            ||.||...   |:|::||.|.::.|...| .:|...|:.::....:....:..:|   :....|.
Zfish    33 DEGADPSG---AMQQVLDNLGELPSTTGAKDIDLIFLKGIMESPIVRSLAKAHERLEDVKLEAVQ 94

  Fly   396 SNGRAPAAEAVGRCRDVLEQLSSTSGGNSLGGKYAKEELMRLLAAPHMQALLHSHDVVARDVYGE 460
            .|.       |....|:|..:|..|..:.     :..||.::|..||.|:||.:||:||...|  
Zfish    95 ENN-------VELVTDILGDISGLSVRDD-----SAAELSKILQEPHFQSLLEAHDMVASKCY-- 145

  Fly   461 EALRVTPPPMVPYLNGDELDNVEGGELQHVTRVRLVQFQKNTDEPMGITLKMTEDGRCIVARIMH 525
            ||      |..|.|..|...|   ..|.....||::..:|...||:|:|.:| :.|..::|||:|
Zfish   146 EA------PAPPELTNDAAVN---NALMQADAVRMIGIRKKAGEPLGVTFRM-DKGDLVIARILH 200

  Fly   526 GGMIHRQATLHVGDEIREINGQPVQHQSVGQLQRMLREARGSVTFKIVPSYRSAPPPCEIFVRAQ 590
            ||:|.||..|||||.|:|:||:.|..... :||.||:|..|.:|.||:||||.||.|.:::|:..
Zfish   201 GGLIDRQGLLHVGDIIKEVNGKDVGTNPT-ELQEMLKECSGGITLKILPSYRDAPAPPQVYVKPH 264

  Fly   591 FDYNPLDDELIPCAQAGISFQVGDILQIISKDDHHWWQARLDTVGGSAGLIPSPELQEWR----- 650
            |||||..|.||||.:||::|:.||||||::::|.:|||| .....|..|||||..|:|.|     
Zfish   265 FDYNPASDNLIPCREAGLAFKRGDILQIVNREDPNWWQA-CHLAEGGTGLIPSQFLEEKRKAFVP 328

  Fly   651 -------IACQTVDKTKQEQVNCSIFGRKKKQCRDKYLAKHNAIFDTLDVVTYEEVVKVPVGDPN 708
                   |.|.|:.            |:|||:.  .||...||.||..::..||||.::    |.
Zfish   329 RDLDGAGILCGTMT------------GKKKKKM--MYLTAKNAEFDRHELQIYEEVARM----PP 375

  Fly   709 FQRKTLVLLGAHGVGRRHIKNTLISKYPDKYAYPIPHTTRPAKPEEENGRSYYFVSHDEMMADIG 773
            ||||||:|:||.|||||.:||.|:..:|.::...:|||:|..:.:|.:|:||.||:..||..||.
Zfish   376 FQRKTLILIGAQGVGRRSLKNRLVVLHPTRFGTTVPHTSRRPRNDERDGQSYRFVTRLEMETDIK 440

  Fly   774 ANEYLEYGTHEDAMYGTKLDTIRRIHTEGKMAILDVEPQALKILRTAEFTPYVVFIAAPSLQNIA 838
            ...|||:|.::..:||||:|:|..:...|:..||||.|||||:|:|.||.|||||||||....:.
Zfish   441 LGRYLEHGEYDGNLYGTKIDSIHEVVNTGRTCILDVNPQALKLLKTPEFMPYVVFIAAPEFDTLK 505

  Fly   839 DY---------------DGSLERLAKESEMLRQLYGHFFDLTIVNNDISETIATLETAIDRVHTT 888
            |.               |..|::...||..:.:.|.|:|||.|||:::......|:::::.:.|.
Zfish   506 DMHKAVVDAGLTTKQLADVDLKKTVDESARILRAYRHYFDLIIVNDNLDCAFEKLQSSVEELCTE 570

  Fly   889 PQWVPVSWLY 898
            ||||||||:|
Zfish   571 PQWVPVSWVY 580

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CASKNP_001262811.1 STKc_CASK 8..308 CDD:270996
L27 347..396 CDD:460717 10/52 (19%)
L27 406..462 CDD:460717 18/55 (33%)
PDZ_CASK-like 494..574 CDD:467267 36/79 (46%)
SH3_CASK 586..646 CDD:213014 31/59 (53%)
Guanylate_kin 710..883 CDD:395500 78/187 (42%)
pals2bXP_005170070.1 L27 43..96 CDD:197794 10/52 (19%)
L27 98..149 CDD:460717 20/63 (32%)
PDZ_MPP6-MPP2-like 170..248 CDD:467268 36/79 (46%)
SH3_MPP 260..317 CDD:212796 30/57 (53%)
Guanylate_kin 377..567 CDD:395500 78/189 (41%)
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.