Protein Alignment CASK and Pals2

DIOPT Version :9

• Sequence 1: NP_001262811.1
• Gene: CASK / 42567
• FlyBaseID: FBgn0013759
• Length: 929
• Species: Drosophila melanogaster
• Sequence 2: XP_006236558.1
• Gene: Pals2 / 362359
• RGDID: 1311833
• Length: 554
• Species: Rattus norvegicus
• Alignment Length: 589
• Identity: 227/589 - (38%)
• Similarity: 337/589 - (57%)
• Gaps: 72/589 - (12%)

  Fly   347 VQRILDCLDDIYSLQDA-HVDADVLRDMLRDNRLHQFLQLFDRIAAT---VVTSNGRAPAAEAVG 407
            :|::|:.|.::.|...| .:|...|:.::.:..:....:..:|:..:   .|:.|.    .|.|
  Rat     1 MQQVLENLTELPSSTGAEEIDLIFLKGIMENPIVKSLAKAHERLEDSKLEAVSDNN----LELV- 60

  Fly   408 RCRDVLEQLSSTSGGNSLGGKYAKEELMRLLAAPHMQALLHSHDVVARDVYGEEALRVTPPPMVP 472
              .::||.::...   |:....|  ||:.:|..||.|:||.:||:||...|       ..||..|
  Rat    61 --NEILEDITPLI---SVDENVA--ELVGILKEPHFQSLLEAHDIVASKCY-------ESPPSSP 111

  Fly   473 YLNGDELDNVEGGELQHVTRVRLVQFQKNTDEPMGITLKMTEDGRCIVARIMHGGMIHRQATLHV 537
            .:|...|:|    :|..|..:|::...|...||:|:|.:: |:...::|||:|||||.||..|||
  Rat   112 EMNIPSLNN----QLLPVDAIRILGIHKRAGEPLGVTFRV-ENNDLVIARILHGGMIDRQGLLHV 171

  Fly   538 GDEIREINGQPVQHQSVGQLQRMLREARGSVTFKIVPSYRSAPPP--------------CEIFVR 588
            ||.|:|:||..|.: :..:||.:|:...||||.||:||||....|              .::||:
  Rat   172 GDIIKEVNGHEVGN-NPKELQELLKNISGSVTLKILPSYRDTIAPQQSYVNMERHPAHVRQVFVK 235

  Fly   589 AQFDYNPLDDELIPCAQAGISFQVGDILQIISKDDHHWWQARLDTVGGSAGLIPSPELQEWRIAC 653
            ..|||||.:|.||||.:||:.|..|:||||::::|.:||||.....|||||||||..|:|.|.|.
  Rat   236 CHFDYNPFNDNLIPCKEAGLKFSKGEILQIVNREDPNWWQASHVKEGGSAGLIPSQFLEEKRKAF 300

  Fly   654 QTVDKTKQEQVN----CSIFGRKKKQCRDKYLAKHNAIFDTLDVVTYEEVVKVPVGDPNFQRKTL 714
                 .:::..|    |.....|||: :..||...||.||..::..||||.|:    |.||||||
  Rat   301 -----VRRDWDNSGPFCGTISNKKKK-KMMYLTTRNAEFDRHEIQIYEEVAKM----PPFQRKTL 355

  Fly   715 VLLGAHGVGRRHIKNTLISKYPDKYAYPIPHTTRPAKPEEENGRSYYFVSHDEMMADIGANEYLE 779
            ||:||.|||||.:||..|...|.::...:|.|:|..:.:|::|::|.|||..||.|||.|.:|||
  Rat   356 VLIGAQGVGRRSLKNRFIVLNPARFGTTVPFTSRKPREDEKDGQAYKFVSRSEMEADIKAGKYLE 420

  Fly   780 YGTHEDAMYGTKLDTIRRIHTEGKMAILDVEPQALKILRTAEFTPYVVFIAAPSLQNIADY---- 840
            :|.:|..:||||:.:|..:...|:..||||.|||||:|||:||.|||||||||.|:.:...
  Rat   421 HGEYEGNLYGTKIGSILDVVQTGRTCILDVNPQALKVLRTSEFMPYVVFIAAPELETLRAMHKAV 485

  Fly   841 -----------DGSLERLAKESEMLRQLYGHFFDLTIVNNDISETIATLETAIDRVHTTPQWVPV 894
                       |..|::...||..:::.|.|:|||.|||:::.:....|:|||:::.|.|||||:
  Rat   486 VDAGITTKLLTDSDLKKTVDESARIQRAYNHYFDLIIVNDNLDKAFENLQTAIEKLRTEPQWVPI 550

  Fly   895 SWLY 898
            ||:|
  Rat   551 SWVY 554

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CASK	NP_001262811.1	STKc_CASK	8..308	CDD:270996
		S_TKc	12..278	CDD:214567
		L27	347..396	CDD:280918	9/52 (17%)
		L27	406..462	CDD:280918	18/55 (33%)
		PDZ_signaling	493..573	CDD:238492	35/79 (44%)
		SH3_CASK	586..646	CDD:213014	34/59 (58%)
		Guanylate_kin	710..883	CDD:279019	83/187 (44%)
		GuKc	720..883	CDD:214504	74/177 (42%)
Pals2	XP_006236558.1	L27	2..55	CDD:197794	9/52 (17%)
		L27	57..108	CDD:397114	19/65 (29%)
		PDZ_signaling	133..206	CDD:238492	34/74 (46%)
		SH3_MPP6	233..293	CDD:212971	34/59 (58%)
		Guanylate_kin	351..541	CDD:395500	84/189 (44%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166352365
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D364535at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.750