Protein Alignment CASK and magu-2

DIOPT Version :10

• Sequence 1: NP_001262811.1
• Gene: CASK / 42567
• FlyBaseID: FBgn0013759
• Length: 929
• Species: Drosophila melanogaster
• Sequence 2: NP_001355433.1
• Gene: magu-2 / 3565703
• WormBaseID: WBGene00006467
• Length: 830
• Species: Caenorhabditis elegans
• Alignment Length: 827
• Identity: 202/827 - (24%)
• Similarity: 353/827 - (42%)
• Gaps: 181/827 - (21%)

  Fly   196 RLYGKGCDVWGAGVMLHVL------LSGR-----LPFLGSGVR---LQQSVARGRLSFEAPEWKS 246
            ||||...:..|..:...::      :.|:     ..::...:|   :|..|.|..|...|....|
 Worm    56 RLYGTAAERAGLSIGDEIVGVNDMKIEGKSYEEVTTYIQECIRRKIIQLKVRRRALEIPAENEAS 120

  Fly   247 I--SANAKDLVMK--MLAANPHHRLSITEVL--DHPWIR-------------------------- 279
            :  ..|:..::..  :::.:..|...:|:.|  ::|.|.
 Worm   121 VFNCTNSNRMITDAYLVSVDKDHIKEVTKRLKKEYPEIHTYDMEYIAATSGPPSVAPRGSVHTNG 185

  Fly   280 ---DRDKLQRTHLADTVEELKR--------YNARRKLKGAVQAIAGGTNMDPLYATDADMPITGA 333
               :|..|:|......::|.||        .::.||.| .:||:|  .|:|||  |:..|.:|..
 Worm   186 FGIERGSLRRPPEQFEMQEKKRKEQENTFLRSSLRKSK-KLQALA--RNVDPL--TNEPMKVTSF 245

  Fly   334 TDEWADEE-----------AGIEAVQRILDCLDDIYSLQDAHVDADVLRD-MLRDNR-LHQFLQL 385
            .:..|:.|           ..|...:.:|:             .::||.| ..:|:| |.:.:..
 Worm   246 ANPLAEVEETPSRKTENGATRITVGEEVLE-------------SSEVLIDEENKDSRQLDEVIIS 297

  Fly   386 FDRIAATVVTSNGR------------APAAEAV--------GRCRDVLEQLSSTSGGNSLGGKYA 430
            .:|||:.:.:..||            ||..:|.        |:|......:.:.|||:|
 Worm   298 VERIASKLSSMQGRESDVAMLRDFFAAPPIQAAIEQTVKQNGKCGTTSSGIGTDSGGDS------ 356

  Fly   431 KEELMRLLAAPHMQALLHSHDVVARDVYGEEALRVTPPPMVPYLNGDELDNVEGGELQHVTRVRL 495
                ....::|....:::.:....|......:..|:|                    ::...|::
 Worm   357 ----SSCTSSPIPPVIMNGNGKSERCPSTSSSSSVSP--------------------RNAPNVKV 397

  Fly   496 VQFQKNTDEPMGITLKMTEDGRCIVARIMHGGMIHRQATLHVGDEIREINGQPVQHQSVGQLQRM 560
            |:..|:.|..:|.|:: .|:.:.||.|::.||::.:......|||:.|:||..::.:.|.::..:
 Worm   398 VEVVKDEDSYLGATVR-NENNKIIVGRVVKGGIVEKMNLFQEGDELLELNGSSLKGKQVNEICDI 461

  Fly   561 LREARGSVTFKIVP-SYRSAPPPCEI---------------FVRAQFDYNPLDDELIPCAQAGIS 609
            ||...|.:||.:.| ..:....|.:.               .:||.|||:|.||..:||.:..:.
 Worm   462 LRNLSGPITFVVAPKEEQDTEQPTDTATNTVTAKKSQQHVQHLRALFDYDPEDDVYVPCKELAMK 526

  Fly   610 FQVGDILQIISKDDHHWWQARLDTVGGS------AGLIPSPELQEWRIACQTVDKTKQEQVNCSI 668
            ||.||||.:::..|.:||||..|   |.      ||||||...::..:......:.:|||.....
 Worm   527 FQRGDILHVLNTKDDNWWQAYRD---GEDIQHSLAGLIPSSSFRQQVVLYADEVEREQEQKRKEC 588

  Fly   669 FGRKKKQCRDKYLAKHN---AIFDTLDVVTYEEVV-KVPVGDPNFQRKTLVLLGAHGVGRRHIKN 729
            .|:|||:...|..|...   ||....|.:|||||| ::|...   .|:.:||.||.|||...:::
 Worm   589 KGKKKKKLEVKKGADEENLPAIGVYSDFLTYEEVVLELPKAT---HRRPIVLCGAEGVGCLKLRD 650

  Fly   730 TLISKYPDKYAYPIPHTTRPAKPEEENGRSYYFVSHDEMMADIGANEYLEYGTHEDAMYGTKLDT 794
            .|:.......|.|:|:|:|..|..|.||..|:|||..:...|..:.:::|:|.::...|||....
 Worm   651 RLLESDRITLACPVPYTSRTPKEGEFNGVHYHFVSKQKFHEDAKSGKFVEFGEYQKFWYGTAKKD 715

  Fly   795 IRRIHTEGKMAILDVEPQALKILRTAEFTPYVVFIAAPSLQ----------NIADYDGSLERLAK 849
            :..:...||..::.::.::|..:|:.:..||::|||||||.          .....|..|:.:..
 Worm   716 VVNVIERGKTCVMTLKAESLGAIRSPDIQPYIIFIAAPSLYILRRQREVEGTFGVKDDELKAILT 780

  Fly   850 ESEMLRQLYGHFFDLTIVNNDISETIATLETAIDRVHTTPQWVPVSW 896
            :|:.:.|.|||.||..|||.|..::...|:..:.:|:|.|.|||.:|
 Worm   781 QSKSIEQKYGHLFDGIIVNIDFEKSFRELKQILMKVNTEPMWVPATW 827

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CASK	NP_001262811.1	STKc_CASK	8..308	CDD:270996	28/168 (17%)
		L27	347..396	CDD:460717	10/50 (20%)
		L27	406..462	CDD:460717	8/63 (13%)
		PDZ_CASK-like	494..574	CDD:467267	23/79 (29%)
		SH3_CASK	586..646	CDD:213014	29/65 (45%)
		Guanylate_kin	710..883	CDD:395500	55/182 (30%)
magu-2	NP_001355433.1	PDZ	<59..109	CDD:214570	6/49 (12%)
		PDZ_MPP5-like	406..475	CDD:467259	20/69 (29%)
		SH3_MPP5	503..565	CDD:212969	29/64 (45%)
		GuKc	642..817	CDD:214504	50/174 (29%)