DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CASK and magu-2

DIOPT Version :9

Sequence 1:	NP_001262811.1	Gene:	CASK / 42567	FlyBaseID:	FBgn0013759	Length:	929	Species:	Drosophila melanogaster
Sequence 2:	NP_001355433.1	Gene:	magu-2 / 3565703	WormBaseID:	WBGene00006467	Length:	830	Species:	Caenorhabditis elegans

Alignment Length:	827	Identity:	202/827 - (24%)
Similarity:	353/827 - (42%)	Gaps:	181/827 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   196 RLYGKGCDVWGAGVMLHVL------LSGR-----LPFLGSGVR---LQQSVARGRLSFEAPEWKS 246
            ||||...:..|..:...::      :.|:     ..::...:|   :|..|.|..|...|....|
Worm    56 RLYGTAAERAGLSIGDEIVGVNDMKIEGKSYEEVTTYIQECIRRKIIQLKVRRRALEIPAENEAS 120

  Fly   247 I--SANAKDLVMK--MLAANPHHRLSITEVL--DHPWIR-------------------------- 279
            :  ..|:..::..  :::.:..|...:|:.|  ::|.|.
Worm   121 VFNCTNSNRMITDAYLVSVDKDHIKEVTKRLKKEYPEIHTYDMEYIAATSGPPSVAPRGSVHTNG 185

  Fly   280 ---DRDKLQRTHLADTVEELKR--------YNARRKLKGAVQAIAGGTNMDPLYATDADMPITGA 333
               :|..|:|......::|.||        .::.||.| .:||:|  .|:|||  |:..|.:|..
Worm   186 FGIERGSLRRPPEQFEMQEKKRKEQENTFLRSSLRKSK-KLQALA--RNVDPL--TNEPMKVTSF 245

  Fly   334 TDEWADEE-----------AGIEAVQRILDCLDDIYSLQDAHVDADVLRD-MLRDNR-LHQFLQL 385
            .:..|:.|           ..|...:.:|:             .::||.| ..:|:| |.:.:..
Worm   246 ANPLAEVEETPSRKTENGATRITVGEEVLE-------------SSEVLIDEENKDSRQLDEVIIS 297

  Fly   386 FDRIAATVVTSNGR------------APAAEAV--------GRCRDVLEQLSSTSGGNSLGGKYA 430
            .:|||:.:.:..||            ||..:|.        |:|......:.:.|||:|
Worm   298 VERIASKLSSMQGRESDVAMLRDFFAAPPIQAAIEQTVKQNGKCGTTSSGIGTDSGGDS------ 356

  Fly   431 KEELMRLLAAPHMQALLHSHDVVARDVYGEEALRVTPPPMVPYLNGDELDNVEGGELQHVTRVRL 495
                ....::|....:::.:....|......:..|:|                    ::...|::
Worm   357 ----SSCTSSPIPPVIMNGNGKSERCPSTSSSSSVSP--------------------RNAPNVKV 397

  Fly   496 VQFQKNTDEPMGITLKMTEDGRCIVARIMHGGMIHRQATLHVGDEIREINGQPVQHQSVGQLQRM 560
            |:..|:.|..:|.|:: .|:.:.||.|::.||::.:......|||:.|:||..::.:.|.::..:
Worm   398 VEVVKDEDSYLGATVR-NENNKIIVGRVVKGGIVEKMNLFQEGDELLELNGSSLKGKQVNEICDI 461

  Fly   561 LREARGSVTFKIVP-SYRSAPPPCEI---------------FVRAQFDYNPLDDELIPCAQAGIS 609
            ||...|.:||.:.| ..:....|.:.               .:||.|||:|.||..:||.:..:.
Worm   462 LRNLSGPITFVVAPKEEQDTEQPTDTATNTVTAKKSQQHVQHLRALFDYDPEDDVYVPCKELAMK 526

  Fly   610 FQVGDILQIISKDDHHWWQARLDTVGGS------AGLIPSPELQEWRIACQTVDKTKQEQVNCSI 668
            ||.||||.:::..|.:||||..|   |.      ||||||...::..:......:.:|||.....
Worm   527 FQRGDILHVLNTKDDNWWQAYRD---GEDIQHSLAGLIPSSSFRQQVVLYADEVEREQEQKRKEC 588

  Fly   669 FGRKKKQCRDKYLAKHN---AIFDTLDVVTYEEVV-KVPVGDPNFQRKTLVLLGAHGVGRRHIKN 729
            .|:|||:...|..|...   ||....|.:|||||| ::|...   .|:.:||.||.|||...:::
Worm   589 KGKKKKKLEVKKGADEENLPAIGVYSDFLTYEEVVLELPKAT---HRRPIVLCGAEGVGCLKLRD 650

  Fly   730 TLISKYPDKYAYPIPHTTRPAKPEEENGRSYYFVSHDEMMADIGANEYLEYGTHEDAMYGTKLDT 794
            .|:.......|.|:|:|:|..|..|.||..|:|||..:...|..:.:::|:|.::...|||....
Worm   651 RLLESDRITLACPVPYTSRTPKEGEFNGVHYHFVSKQKFHEDAKSGKFVEFGEYQKFWYGTAKKD 715

  Fly   795 IRRIHTEGKMAILDVEPQALKILRTAEFTPYVVFIAAPSLQ----------NIADYDGSLERLAK 849
            :..:...||..::.::.::|..:|:.:..||::|||||||.          .....|..|:.:..
Worm   716 VVNVIERGKTCVMTLKAESLGAIRSPDIQPYIIFIAAPSLYILRRQREVEGTFGVKDDELKAILT 780

  Fly   850 ESEMLRQLYGHFFDLTIVNNDISETIATLETAIDRVHTTPQWVPVSW 896
            :|:.:.|.|||.||..|||.|..::...|:..:.:|:|.|.|||.:|
Worm   781 QSKSIEQKYGHLFDGIIVNIDFEKSFRELKQILMKVNTEPMWVPATW 827

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CASK	NP_001262811.1	STKc_CASK	8..308	CDD:270996	28/168 (17%)
		S_TKc	12..278	CDD:214567	18/101 (18%)
		L27	347..396	CDD:280918	10/50 (20%)
		L27	406..462	CDD:280918	8/63 (13%)
		PDZ_signaling	493..573	CDD:238492	24/79 (30%)
		SH3_CASK	586..646	CDD:213014	29/65 (45%)
		Guanylate_kin	710..883	CDD:279019	55/182 (30%)
		GuKc	720..883	CDD:214504	50/172 (29%)
magu-2	NP_001355433.1	PDZ	<59..107	CDD:238080	5/47 (11%)
		PDZ_signaling	408..474	CDD:238492	20/66 (30%)
		SH3_MPP5	503..565	CDD:212969	29/64 (45%)
		GuKc	642..817	CDD:214504	50/174 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810