DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CASK and dlg1

DIOPT Version :9

Sequence 1:	NP_001262811.1	Gene:	CASK / 42567	FlyBaseID:	FBgn0013759	Length:	929	Species:	Drosophila melanogaster
Sequence 2:	NP_001162718.1	Gene:	dlg1 / 32083	FlyBaseID:	FBgn0001624	Length:	1030	Species:	Drosophila melanogaster

Alignment Length:	643	Identity:	134/643 - (20%)
Similarity:	215/643 - (33%)	Gaps:	226/643 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   219 LPFLGSGVRLQQSVARGRLSFEAPEWKSISANAKDLVMKMLAANPHHRL-SITEVLDHPWIRDRD 282
            |..|.....:||..|. .|.. |.:|:      ||.....:|.|...|: |.||....|.:..:.
  Fly   355 LTLLDDSKSIQQKTAE-TLQI-ATKWE------KDGQAVKIADNQRMRIESDTENAKEPTVEQQQ 411

  Fly   283 KLQRTHL----------------------ADTVE----------ELKRYNARRKLKGAVQAIAGG 315
            |.|:...                      :.||.          :|:|.|:     |...:||||
  Fly   412 KQQQAQQRSSRSPQQQNPQQQQGSKSRSGSQTVNGDDSWLYEDIQLERGNS-----GLGFSIAGG 471

  Fly   316 TNMDPLYATDADMPITGATDEWADEEAGIEAVQRILDCLDDIYSLQDAHVDA-DVLR-------- 371
            |: :|...||..:.||......|....|..::..|:..::|:..:...|..| |.|:
  Fly   472 TD-NPHIGTDTSIYITKLISGGAAAADGRLSINDIIVSVNDVSVVDVPHASAVDALKKAGNVVKL 535

  Fly   372 ----------------------------------DMLR--------------------DNRLHQF 382
                                              |:::                    ||.:: .
  Fly   536 HVKRKRGTATTPAAGSAAGDARDSAASGPKVIEIDLVKGGKGLGFSIAGGIGNQHIPGDNGIY-V 599

  Fly   383 LQLFDRIAATV------------VTSNGRAPAAE------AVGRCRDVLEQL-----------SS 418
            .:|.|..||.|            |.:||.....|      ||...:.:.:::           :|
  Fly   600 TKLMDGGAAQVDGRLSIGDKLIAVRTNGSEKNLENVTHELAVATLKSITDKVTLIIGKTQHLTTS 664

  Fly   419 TSGGNSLGGKYAKEELMR---LLAAPHMQALLH----------SHDVVARDVYGEEALRVTPPPM 470
            .|||.. ||..:.::|.:   .||....|:.:|          |........|....:....||.
  Fly   665 ASGGGG-GGLSSGQQLSQSQSQLATSQSQSQVHQQQHATPMVNSQSTEPGSRYASTNVLAAVPPG 728

  Fly   471 VPYLNGDELDNVEGGELQHVTR-VRLVQFQKNTDEPMGITLKMT--EDGRCI-VARIMHGGMIHR 531
            .|          .....:.:|| .|.:..||.   |.|:...:.  |||:.| |:.|:.||....
  Fly   729 TP----------RAVSTEDITREPRTITIQKG---PQGLGFNIVGGEDGQGIYVSFILAGGPADL 780

  Fly   532 QATLHVGDEIREINGQPVQHQSVGQLQRMLREARGSVTFKIVPSYRSAPPPCE------------ 584
            .:.|..||::..:|...:.|.:..:..:.|:.:.|.||  ::..||    |.|
  Fly   781 GSELKRGDQLLSVNNVNLTHATHEEAAQALKTSGGVVT--LLAQYR----PEEYNRFEARIQELK 839

  Fly   585 ---------------------IFVRAQFDYNPLDDELIPCAQAGISFQVGDILQIISKDDHHWWQ 628
                                 ::|||.|||:|..|:.:|  ..|:.|:.||||.:.:..|..|||
  Fly   840 QQAALGAGGSGTLLRTTQKRSLYVRALFDYDPNRDDGLP--SRGLPFKHGDILHVTNASDDEWWQ 902

  Fly   629 ARL---DTVGGSAGLIPSPELQEWRIACQTVDKTKQEQVNC---------SIFGRKKK 674
            ||.   |......|::||.  :.|....:..|::.:.|.:.         |...||||
  Fly   903 ARRVLGDNEDEQIGIVPSK--RRWERKMRARDRSVKFQGHAAANNNLDKQSTLDRKKK 958

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CASK	NP_001262811.1	STKc_CASK	8..308	CDD:270996	24/121 (20%)
		S_TKc	12..278	CDD:214567	17/59 (29%)
		L27	347..396	CDD:280918	15/123 (12%)
		L27	406..462	CDD:280918	14/79 (18%)
		PDZ_signaling	493..573	CDD:238492	22/82 (27%)
		SH3_CASK	586..646	CDD:213014	25/62 (40%)
		Guanylate_kin	710..883	CDD:279019
		GuKc	720..883	CDD:214504
dlg1	NP_001162718.1	L27_1	303..359	CDD:286187	1/3 (33%)
		PDZ	454..540	CDD:214570	22/91 (24%)
		PDZ_signaling	566..655	CDD:238492	14/89 (16%)
		PDZ_signaling	742..820	CDD:238492	22/82 (27%)
		SH3_DLG-like	862..922	CDD:212795	25/63 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0194
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810