DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CASK and Card10

DIOPT Version :9

Sequence 1:NP_001262811.1 Gene:CASK / 42567 FlyBaseID:FBgn0013759 Length:929 Species:Drosophila melanogaster
Sequence 2:XP_038935185.1 Gene:Card10 / 315120 RGDID:1304949 Length:1109 Species:Rattus norvegicus


Alignment Length:464 Identity:109/464 - (23%)
Similarity:159/464 - (34%) Gaps:148/464 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   184 CPHYMAPEVVTRRLYGKGCDVWGAGVMLHVLLSG---------------RLPFLGSGVRLQQSVA 233
            ||...|    ..||...||.:  ..:.|.:.:||               .||.||.  |...:|.
  Rat   656 CPSLAA----ASRLEANGCSL--LELSLAIRVSGWSPSGGLDPQDKSPDSLPILGD--RWSGAVV 712

  Fly   234 RGRLSFEAP-----EWKSISANAKDLVMKMLAANPHHRLSITEVLDHPWIRDRDKLQRTHLADTV 293
            |..||  .|     |.|...|....|....|.|....|..       ||          :.:.|:
  Rat   713 RRVLS--GPGSARTEQKEPRAEGSGLEGTGLEAEVQQRTL-------PW----------NQSSTL 758

  Fly   294 EELKRYNARRKLKGAVQAIAGGTNMDPLY-ATDADMPITGATDEWADEEAGIEAVQRILDCLDDI 357
            ..|....|.:....|:...|.|...:|.| ..:..:|      |.||..|.....|.||..:|..
  Rat   759 PFLLDSKACQSFHEALDVWAKGPGAEPFYIRANFSLP------ERADPHALCVKAQEILRLVDPA 817

  Fly   358 YSLQD----AHVDADVLRDMLRD-----NRLHQFLQLFDRIAATVVTSNGRAPAA----EAVGRC 409
            |..:.    ..||...|||:.|.     .|..|.|::.::.   :::|..|:|.:    .|:|..
  Rat   818 YKRRQEWFCTRVDTLTLRDLDRGTVPNYQRAQQLLEVQEKY---LISSRHRSPRSNLKKRALGLV 879

  Fly   410 RDVLEQLSSTSGGNSLGGKYAKE-------ELMRLLAAPH--MQALLHSHDVVARDVYGEEALR- 464
            |      ...:||.:  |..|::       ||.|.| .|:  ::.||.|            ||| 
  Rat   880 R------PKPAGGTA--GDSAEQLPADPCSELERSL-KPYSLVRPLLVS------------ALRP 923

  Fly   465 --VTPPPMVPYLNGDELD-----------NVE--GGELQHV-----------------TRVRLVQ 497
              :.|..:.|.|..:.||           :.|  .||.|..                 :|:|.:|
  Rat   924 VVLLPECLAPRLIRNLLDLPSSRLDFQVCSAESLSGEEQCTSSAPGAPKAWPASAGLGSRIRAIQ 988

  Fly   498 FQKNTDEPMGITLKMTEDGRCIVARIMHGG----MIHRQATLHVGDEIREINGQPVQHQSVGQLQ 558
                  |.:|....:.|.|...|..::|..    :||.:.|.....|||.:.|:|....|     
  Rat   989 ------ESVGKKHCLLELGARGVRELVHSEVYPIVIHVEVTEKNVREIRSLLGRPGWRDS----- 1042

  Fly   559 RMLREARGS 567
            .:||:.|||
  Rat  1043 ELLRQCRGS 1051

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CASKNP_001262811.1 STKc_CASK 8..308 CDD:270996 32/143 (22%)
S_TKc 12..278 CDD:214567 28/113 (25%)
L27 347..396 CDD:280918 14/57 (25%)
L27 406..462 CDD:280918 14/64 (22%)
PDZ_signaling 493..573 CDD:238492 22/79 (28%)
SH3_CASK 586..646 CDD:213014
Guanylate_kin 710..883 CDD:279019
GuKc 720..883 CDD:214504
Card10XP_038935185.1 CARD_CARD10_CARMA3 76..161 CDD:260069
Smc <196..>499 CDD:224117
SH3 784..849 CDD:418401 19/70 (27%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0194
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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