DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CASK and Mpp7

DIOPT Version :9

Sequence 1:	NP_001262811.1	Gene:	CASK / 42567	FlyBaseID:	FBgn0013759	Length:	929	Species:	Drosophila melanogaster
Sequence 2:	XP_017456050.1	Gene:	Mpp7 / 307035	RGDID:	1305675	Length:	601	Species:	Rattus norvegicus

Alignment Length:	628	Identity:	205/628 - (32%)
Similarity:	324/628 - (51%)	Gaps:	119/628 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   353 CLDDIYSLQDA-------HVDAD----VLRDMLRDNRLHQFLQLFDRI-----AATVVTSNGRAP 401
            |...:|.|..|       |||:.    .|.||..:..||..:::.:::     .:.|...:|.|.
  Rat    10 CDTGLYELLAALPAQLQPHVDSQEDLTFLWDMFGEKSLHSLVKIHEKLHYYEKQSPVPILHGAAA 74

  Fly   402 AAEAVGRCRDVLEQLSSTSGGNSLGGKYAKEELMRLLAAPHMQALLHSHDVVARDVYGEEALRVT 466
            .|:      |:.::|.:....:.:      .||::||:.|:::|||..||.||:..|..    |.
  Rat    75 LAD------DLADELQNKPPNSEI------RELLKLLSKPNVKALLSVHDTVAQKSYDP----VL 123

  Fly   467 PPPMVPYLNGDELDNVEGGELQHVTRVRLVQFQKNTDEPMGITLKMTED-GRCIVARIMHGGMIH 530
            ||  :|    |::|:.|..       |::::..||. ||:|.|:|..|. |...|||||.||...
  Rat   124 PP--MP----DDIDDEEDS-------VKIIRLVKNR-EPLGATIKKDEQTGAITVARIMRGGAAD 174

  Fly   531 RQATLHVGDEIREINGQPVQHQSVGQLQRMLREARGSVTFKIVPSYRSAPPPCE--IFVRAQFDY 593
            |...:|||||:||:||.||:.:...::.::|.:::|::||||:||.:...|..|  ||::|.|||
  Rat   175 RSGLIHVGDELREVNGIPVEDKRPEEIIQILSQSQGAITFKIIPSTKEEIPSKEGKIFIKALFDY 239

  Fly   594 NPLDDELIPCAQAGISFQVGDILQIISKDDHHWWQARLD-TVGGSAGLIPSPELQEWRIACQTVD 657
            :|.:|:.|||.:||:||:.||||||:|:||..||||:.: .....||||||...||.|:|.:..:
  Rat   240 DPKEDKAIPCKEAGLSFRKGDILQIMSQDDATWWQAKHEGDTNPRAGLIPSKHFQERRLALRRPE 304

  Fly   658 -----------KTKQEQVNCS----------------IFG---------RKKKQCRDKYLAKHNA 686
                       |:.:|.|.|.                |.|         :.||..:..|..|.:.
  Rat   305 IVVQPLKLSNRKSYEETVECEEIKEDAGHDGNNSGPYIAGFRRSFRLSRKDKKTNKSMYECKKSE 369

  Fly   687 IFDTLDVVTYEEVVKVPVGDPNFQRKT------LVLLGAHGVGRRHIKNTLISKYPDKYAYPIPH 745
            .:||.||.|||||..       ::|:|      :||:|..|||...:|..|:......|...:||
  Rat   370 QYDTADVPTYEEVTP-------YRRQTHDKYRLVVLVGPVGVGLNELKRKLLMSDTQHYGVTVPH 427

  Fly   746 TTRPAKPEEENGRSYYFVSHDEMMADIGANEYLEYGTHEDAMYGTKLDTIRRIHTEGKMAILDVE 810
            |||..:.:|.:|..|.|:|......|:..|:::|||.:::..|||.:|::|.:..:.|:.:|||:
  Rat   428 TTRARRSQESDGVEYIFISKHLFETDVQNNKFIEYGEYKNNYYGTSIDSVRSVLAKNKVCLLDVQ 492

  Fly   811 PQALKILRTAEFTPYVVFIAAPSLQNI------------ADYDGS--------LERLAKESEMLR 855
            |..:|.|||.||.|||:||..||::.:            .|..|:        .:.:.|.::::.
  Rat   493 PHTVKHLRTLEFKPYVIFIKPPSIERLRETRKNAKIISSRDDQGTAKPFTEEDFQEMIKSAQIME 557

  Fly   856 QLYGHFFDLTIVNNDISETIATLETAIDRVHTTPQWVPVSWLY 898
            ..|||.||..|:|:|::.....|:|..|::.|...|||||||:
  Rat   558 SQYGHLFDKIIINDDLTVAFNELKTTFDKLETDAHWVPVSWLH 600

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CASK	NP_001262811.1	STKc_CASK	8..308	CDD:270996
		S_TKc	12..278	CDD:214567
		L27	347..396	CDD:280918	13/58 (22%)
		L27	406..462	CDD:280918	15/55 (27%)
		PDZ_signaling	493..573	CDD:238492	34/80 (43%)
		SH3_CASK	586..646	CDD:213014	33/60 (55%)
		Guanylate_kin	710..883	CDD:279019	62/198 (31%)
		GuKc	720..883	CDD:214504	57/182 (31%)
Mpp7	XP_017456050.1	L27	16..68	CDD:197794	11/51 (22%)
		L27	<88..125	CDD:197794	14/46 (30%)
		PDZ_signaling	137..217	CDD:238492	34/80 (43%)
		SH3_MPP7	232..292	CDD:212966	33/59 (56%)
		GuKc	409..588	CDD:214504	55/178 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810