DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CASK and GUK1

DIOPT Version :9

Sequence 1:	NP_001262811.1	Gene:	CASK / 42567	FlyBaseID:	FBgn0013759	Length:	929	Species:	Drosophila melanogaster
Sequence 2:	XP_005273161.1	Gene:	GUK1 / 2987	HGNCID:	4693	Length:	263	Species:	Homo sapiens

Alignment Length:	181	Identity:	47/181 - (25%)
Similarity:	94/181 - (51%)	Gaps:	10/181 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   712 KTLVLLGAHGVGRRHIKNTLISKYPDKYAYPIPHTTRPAKPEEENGRSYYFVSHDEMMADIGANE 776
            :.:||.|..|.|:..:...|:.::...:.:.:.||||..:|.||||:.||||:.:.|..||.|.:
Human    71 RPVVLSGPSGAGKSTLLKRLLQEHSGIFGFSVSHTTRNPRPGEENGKDYYFVTREVMQRDIAAGD 135

  Fly   777 YLEYGTHEDAMYGTKLDTIRRIHTEGKMAILDVEPQALKILRTAEFTPYVVFIAAPSL------- 834
            ::|:......:|||....::.:....::.:|||:.|.::.::..:..|..:.:..|||
Human   136 FIEHAEFSGNLYGTSKVAVQAVQAMNRICVLDVDLQGVRNIKATDLRPIYISVQPPSLHVLEQRL 200

  Fly   835 --QNIADYDGSLERL-AKESEMLRQLYGHFFDLTIVNNDISETIATLETAI 882
              :|....:..::|| |.:::|........||:.|:|:.:.:..|.|:.|:
Human   201 RQRNTETEESLVKRLAAAQADMESSKEPGLFDVVIINDSLDQAYAELKEAL 251

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CASK	NP_001262811.1	STKc_CASK	8..308	CDD:270996
		S_TKc	12..278	CDD:214567
		L27	347..396	CDD:280918
		L27	406..462	CDD:280918
		PDZ_signaling	493..573	CDD:238492
		SH3_CASK	586..646	CDD:213014
		Guanylate_kin	710..883	CDD:279019	47/181 (26%)
		GuKc	720..883	CDD:214504	44/173 (25%)
GUK1	XP_005273161.1	Guanylate_kin	69..254	CDD:279019	47/181 (26%)
GUK1	XP_005273161.1	guanyl_kin	71..253	CDD:213788	47/181 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810