DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CASK and Cask

DIOPT Version :9

Sequence 1:	NP_001262811.1	Gene:	CASK / 42567	FlyBaseID:	FBgn0013759	Length:	929	Species:	Drosophila melanogaster
Sequence 2:	XP_038955479.1	Gene:	Cask / 29647	RGDID:	62004	Length:	972	Species:	Rattus norvegicus

Alignment Length:	993	Identity:	572/993 - (57%)
Similarity:	711/993 - (71%)	Gaps:	116/993 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MTEDEILFDDVYELCEVIGKGPFSIVRRCIHRESNQQFAVKIVDVAKFTASPGLST------ADL 59
            |.:|::||:|||||||||||||||:|||||:||:.||||||||||||||:||||||      ::|
  Rat     1 MADDDVLFEDVYELCEVIGKGPFSVVRRCINRETGQQFAVKIVDVAKFTSSPGLSTEGKRWISNL 65

  Fly    60 KREATICHMLKHPHIVELLETYSSEGMLYMVFEFMEGSDLCFEVVRRAVAGFVYSEAVACHYMRQ 124
            ||||:|||||||||||||||||||:||||||||||:|:|||||:|:||.||||||||||.|||||
  Rat    66 KREASICHMLKHPHIVELLETYSSDGMLYMVFEFMDGADLCFEIVKRADAGFVYSEAVASHYMRQ 130

  Fly   125 ILEALRYCHENDILHRDVRPACALLATVDNSAPVKLGGFGSAIQLPGTRETIETHGRVGCPHYMA 189
            |||||||||:|:|:||||:|.|.|||:.:|||||||||||.||||  ....:...||||.||:||
  Rat   131 ILEALRYCHDNNIIHRDVKPHCVLLASKENSAPVKLGGFGVAIQL--GESGLVAGGRVGTPHFMA 193

  Fly   190 PEVVTRRLYGKGCDVWGAGVMLHVLLSGRLPFLGSGVRLQQSVARGRLSFEAPEWKSISANAKDL 254
            ||||.|..|||..||||.||:|.:||||.|||.|:..||.:.:.:|:......:|..||.:||||
  Rat   194 PEVVKREPYGKPVDVWGCGVILFILLSGCLPFYGTKERLFEGIIKGKYKMNPRQWSHISESAKDL 258

  Fly   255 VMKMLAANPHHRLSITEVLDHPWIRDRDK-LQRTHLADTVEELKRYNARRKLKGAVQAIAGGTNM 318
            |.:||..:|..|:::.|.|:|||:::||: ..:.||.:|||:|:::||||||||||.|.......
  Rat   259 VRRMLMLDPAERITVYEALNHPWLKERDRYAYKIHLPETVEQLRKFNARRKLKGAVLAAVSSHKF 323

  Fly   319 DPLYATDADMPITGATDEWAD--EE-------AGIEAVQRILDCLDDIYSLQD-AHVDADVLRDM 373
            :..|   .|.|     :|..|  |:       |...||.::||.|::|::|.| :..|.|.|..:
  Rat   324 NSFY---GDPP-----EELPDFSEDPTSSGLLAAERAVSQVLDSLEEIHALTDCSEKDLDFLHSV 380

  Fly   374 LRDNRLHQFLQLFDRIAATVVTSNGRAPAAEAVGRCRDVLEQLSSTSGGNSLGGKYAKEELMRLL 438
            .:|..||..|.|:|:| .|..:...|.|.::||.|.::|||::|.....|.      .:||.|:|
  Rat   381 FQDQHLHTLLDLYDKI-NTKSSPQIRNPPSDAVQRAKEVLEEISCYPENND------AKELKRIL 438

  Fly   439 AAPHMQALLHSHDVVARDVYGEEALRVTPPPMVPYLNGDELDNVEGG-ELQHVTRVRLVQFQKNT 502
            ..||..|||.:|||||.:||.:|||||||||..||||||..::..|. ::::|||||||||||||
  Rat   439 TQPHFMALLQTHDVVAHEVYSDEALRVTPPPTSPYLNGDSPESANGDMDMENVTRVRLVQFQKNT 503

  Fly   503 DEPMGITLKMTEDGRCIVARIMHGGMIHRQATLHVGDEIREINGQPVQHQSVGQLQRMLREARGS 567
            ||||||||||.|...|||||||||||||||.|||||||||||||..|.:|:|.|||:||||.|||
  Rat   504 DEPMGITLKMNELNHCIVARIMHGGMIHRQGTLHVGDEIREINGISVANQTVEQLQKMLREMRGS 568

  Fly   568 VTFKIVPSYRSAPPPCE-----------------------------------IFVRAQFDYNPLD 597
            :|||||||||:....||                                   |:|||||:|:|..
  Rat   569 ITFKIVPSYRTQSSSCERDSPSTSRQSPANGHSSTNNSVSDLPSTTQPKGRQIYVRAQFEYDPAK 633

  Fly   598 DELIPCAQAGISFQVGDILQIISKDDHHWWQARLD-TVGGSAGLIPSPELQEWRIACQTVDKTKQ 661
            |:||||.:|||.|:||||:||||||||:|||.:|: :..|:|||||||||||||:||..::||||
  Rat   634 DDLIPCKEAGIRFRVGDIIQIISKDDHNWWQGKLENSKNGTAGLIPSPELQEWRVACIAMEKTKQ 698

  Fly   662 E-QVNCSIFGRKKKQCRDKYLAKHNAIFDTLDVVTYEEVVKVPVGDPNFQRKTLVLLGAHGVGRR 725
            | |.:|:.||:||||.:|||||||||:||.||:||||||||:|.    |:|||||||||||||||
  Rat   699 EQQASCTWFGKKKKQYKDKYLAKHNAVFDQLDLVTYEEVVKLPA----FKRKTLVLLGAHGVGRR 759

  Fly   726 HIKNTLISKYPDKYAYPIPHTTRPAKPEEENGRSYYFVSHDEMMADIGANEYLEYGTHEDAMYGT 790
            |||||||:|:|:::||||||||||.|.:||||::|||||||:||.||..|||||||:||||||||
  Rat   760 HIKNTLITKHPERFAYPIPHTTRPPKKDEENGKNYYFVSHDQMMQDISNNEYLEYGSHEDAMYGT 824

  Fly   791 KLDTIRRIHTEGKMAILDVEPQ----------------------------------------ALK 815
            ||:|||:||.:|.:||||||||                                        |||
  Rat   825 KLETIRKIHEQGLIAILDVEPQGLEKSSGQGWLEAKSQSWSWSSTSSPWVPHWSSPERRFLLALK 889

  Fly   816 ILRTAEFTPYVVFIAAPSLQNIADYDGSLERLAKESEMLRQLYGHFFDLTIVNNDISETIATLET 880
            :||||||.|:|||||||::....:.|.||:||.|||::|::.|.|:|||||:||:|.|||..||.
  Rat   890 VLRTAEFAPFVVFIAAPTITPGLNEDESLQRLQKESDVLQRTYAHYFDLTIINNEIDETIRHLEE 954

  Fly   881 AIDRVHTTPQWVPVSWLY 898
            |::.|.|.||||||||:|
  Rat   955 AVELVCTAPQWVPVSWVY 972

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CASK	NP_001262811.1	STKc_CASK	8..308	CDD:270996	202/306 (66%)
		S_TKc	12..278	CDD:214567	183/271 (68%)
		L27	347..396	CDD:280918	18/49 (37%)
		L27	406..462	CDD:280918	23/55 (42%)
		PDZ_signaling	493..573	CDD:238492	65/79 (82%)
		SH3_CASK	586..646	CDD:213014	40/60 (67%)
		Guanylate_kin	710..883	CDD:279019	123/212 (58%)
		GuKc	720..883	CDD:214504	114/202 (56%)
Cask	XP_038955479.1	STKc_CASK	8..313	CDD:270996	202/306 (66%)
		L27	354..407	CDD:197794	18/53 (34%)
		L27	412..462	CDD:397114	23/55 (42%)
		PDZ_signaling	494..574	CDD:238492	65/79 (82%)
		SH3_CASK	622..683	CDD:213014	40/60 (67%)
		Guanylate_kin	744..957	CDD:395500	123/212 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	383	1.000	Domainoid score	I791
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H2736
Inparanoid	1	1.050	1109	1.000	Inparanoid score	I215
OMA	1	1.010	-	-		QHG49156
OrthoDB	1	1.010	-	-		D364535at33208
OrthoFinder	1	1.000	-	-		FOG0006854
OrthoInspector	1	1.000	-	-		oto97538
orthoMCL	1	0.900	-	-		OOG6_105717
Panther	1	1.100	-	-	O	PTHR23122
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4946
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.980