DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CASK and caska

DIOPT Version :9

Sequence 1:	NP_001262811.1	Gene:	CASK / 42567	FlyBaseID:	FBgn0013759	Length:	929	Species:	Drosophila melanogaster
Sequence 2:	XP_017213110.1	Gene:	caska / 259195	ZFINID:	ZDB-GENE-020802-4	Length:	965	Species:	Danio rerio

Alignment Length:	985	Identity:	570/985 - (57%)
Similarity:	717/985 - (72%)	Gaps:	107/985 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MTEDEILFDDVYELCEVIGKGPFSIVRRCIHRESNQQFAVKIVDVAKFTASPGLSTADLKREATI 65
            |.:|::||:|||||||||||||||:|||||:||:.||||||||||||||:||||||.||||||:|
Zfish     1 MADDDVLFEDVYELCEVIGKGPFSVVRRCINRETGQQFAVKIVDVAKFTSSPGLSTEDLKREASI 65

  Fly    66 CHMLKHPHIVELLETYSSEGMLYMVFEFMEGSDLCFEVVRRAVAGFVYSEAVACHYMRQILEALR 130
            ||||||||||||||||||:||||||||||:|:|||||:|:||.||||||||||.|||||||||||
Zfish    66 CHMLKHPHIVELLETYSSDGMLYMVFEFMDGADLCFEIVKRADAGFVYSEAVASHYMRQILEALR 130

  Fly   131 YCHENDILHRDVRPACALLATVDNSAPVKLGGFGSAIQLPGTRETIETHGRVGCPHYMAPEVVTR 195
            |||:|:|:||||:|.|.|||:.:|||||||||||.||||  ....:...||||.||:||||||.|
Zfish   131 YCHDNNIIHRDVKPHCVLLASKENSAPVKLGGFGVAIQL--GESGLVAGGRVGTPHFMAPEVVKR 193

  Fly   196 RLYGKGCDVWGAGVMLHVLLSGRLPFLGSGVRLQQSVARGRLSFEAP-EWKSISANAKDLVMKML 259
            ..|||..||||.||:|.:||||.|||.|:..||.:::.:|:.....| :|..||.:|||||.:||
Zfish   194 EPYGKPVDVWGCGVILFILLSGCLPFYGTKERLFEAIIKGKYKVMNPRQWGHISESAKDLVRRML 258

  Fly   260 AANPHHRLSITEVLDHPWIRDRDK-LQRTHLADTVEELKRYNARRKLKGAVQAIAGGTNMDPLYA 323
            ..:|..|:::.|.|:|||:::||: ..:.||.:|||:|:::||||||||||.|.......:..|
Zfish   259 MLDPAERITVYEALNHPWLKERDRYAYKIHLPETVEQLRKFNARRKLKGAVLAAVSSHKFNSFY- 322

  Fly   324 TDADMPITGATDEWAD--EE-------AGIEAVQRILDCLDDIYSLQD-AHVDADVLRDMLRDNR 378
              .|.|     :|..|  |:       |...||.::||.|::|::|.| :..|.|.|..:.:|:.
Zfish   323 --GDPP-----EELPDFSEDPTSSGLLAAERAVSQVLDSLEEIHALTDCSEKDLDFLHSVFQDHH 380

  Fly   379 LHQFLQLFDRIAATVVTSNGRAPAAEAVGRCRDVLEQLSSTSGGNSLGGKYAK------------ 431
            ||..|.|:|:| .|..:...|.|:::||.|.::     :||..|:|...|:.:
Zfish   381 LHTLLDLYDKI-NTKSSPQIRNPSSDAVQRAKE-----TSTEDGSSAALKHLEYVLEEISCYPEN 439

  Fly   432 ---EELMRLLAAPHMQALLHSHDVVARDVYGEEALRVTPPPMVPYLNGDELDNVEGG-ELQHVTR 492
               :||.|:|..||..|||.:|||||.:||.::|:||||||..||||||..::..|. ::::|||
Zfish   440 TDAKELRRILTQPHFMALLQTHDVVAHEVYSDDAMRVTPPPTSPYLNGDSPESTNGDMDIENVTR 504

  Fly   493 VRLVQFQKNTDEPMGITLKMTEDGRCIVARIMHGGMIHRQATLHVGDEIREINGQPVQHQSVGQL 557
            ||||||||||||||||||||.:...|||||||||||||||.|||:|||||||||..|.:|:|.||
Zfish   505 VRLVQFQKNTDEPMGITLKMNDLNHCIVARIMHGGMIHRQGTLHIGDEIREINGISVANQTVEQL 569

  Fly   558 QRMLREARGSVTFKIVPSYRSAPPPCE-------------------------------------- 584
            |:||||.|||:|||||||||:....||
Zfish   570 QKMLREMRGSITFKIVPSYRTQQSSCEKESPSTSRQSPANGHSSINSSILDLPSTIQPKGRQISR 634

  Fly   585 ----------IFVRAQFDYNPLDDELIPCAQAGISFQVGDILQIISKDDHHWWQARLD-TVGGSA 638
                      |:|||||:|:|:.|:||||.:|||.|:||||:|||:||||:|||.:|: |..|:|
Zfish   635 PPIKDKFSIKIYVRAQFEYDPVKDDLIPCKEAGIRFRVGDIIQIINKDDHNWWQGKLENTKNGTA 699

  Fly   639 GLIPSPELQEWRIACQTVDKTKQE-QVNCSIFGRKKKQCRDKYLAKHNAIFDTLDVVTYEEVVKV 702
            ||||||||||||:||..::||||| |.:|:.||:||||.:|||||||||:||.||:||||||||:
Zfish   700 GLIPSPELQEWRVACIAMEKTKQEQQASCTWFGKKKKQYKDKYLAKHNAVFDQLDLVTYEEVVKL 764

  Fly   703 PVGDPNFQRKTLVLLGAHGVGRRHIKNTLISKYPDKYAYPIPHTTRPAKPEEENGRSYYFVSHDE 767
            |.    |:||||||||||||||||||||||:|:||::||||||||||.|.:||||::|:|||||:
Zfish   765 PA----FKRKTLVLLGAHGVGRRHIKNTLITKHPDRFAYPIPHTTRPPKKDEENGKNYFFVSHDQ 825

  Fly   768 MMADIGANEYLEYGTHEDAMYGTKLDTIRRIHTEGKMAILDVEPQALKILRTAEFTPYVVFIAAP 832
            ||.||..|:|||||:||||||||:|:|||:||.:|.:|||||||||||:||||||.|||||||||
Zfish   826 MMQDISNNDYLEYGSHEDAMYGTRLETIRKIHEQGLIAILDVEPQALKVLRTAEFAPYVVFIAAP 890

  Fly   833 S----LQNIADY-----DGSLERLAKESEMLRQLYGHFFDLTIVNNDISETIATLETAIDRVHTT 888
            :    :..:..:     |.||:||.||||:|::.|.|:||.||:||:|.|||..||.|||.|.:|
Zfish   891 TITPGMNELPRWCRKLPDESLQRLQKESEILQKTYAHYFDQTIINNEIDETIRLLEEAIDMVCST 955

  Fly   889 PQWVPVSWLY 898
            .|||||||:|
Zfish   956 AQWVPVSWVY 965

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CASK	NP_001262811.1	STKc_CASK	8..308	CDD:270996	204/301 (68%)
		S_TKc	12..278	CDD:214567	185/266 (70%)
		L27	347..396	CDD:280918	18/49 (37%)
		L27	406..462	CDD:280918	23/70 (33%)
		PDZ_signaling	493..573	CDD:238492	63/79 (80%)
		SH3_CASK	586..646	CDD:213014	40/60 (67%)
		Guanylate_kin	710..883	CDD:279019	122/181 (67%)
		GuKc	720..883	CDD:214504	113/171 (66%)
caska	XP_017213110.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	383	1.000	Domainoid score	I785
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H2736
Inparanoid	1	1.050	1116	1.000	Inparanoid score	I217
OMA	1	1.010	-	-		QHG49156
OrthoDB	1	1.010	-	-		D364535at33208
OrthoFinder	1	1.000	-	-		FOG0006854
OrthoInspector	1	1.000	-	-		oto41426
orthoMCL	1	0.900	-	-		OOG6_105717
Panther	1	1.100	-	-	O	PTHR23122
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4946
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.840