DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CASK and Camk2a

DIOPT Version :9

Sequence 1:	NP_001262811.1	Gene:	CASK / 42567	FlyBaseID:	FBgn0013759	Length:	929	Species:	Drosophila melanogaster
Sequence 2:	XP_038952520.1	Gene:	Camk2a / 25400	RGDID:	2261	Length:	489	Species:	Rattus norvegicus

Alignment Length:	307	Identity:	131/307 - (42%)
Similarity:	189/307 - (61%)	Gaps:	17/307 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 FDDVYELCEVIGKGPFSIVRRCIHRESNQQFAVKIVDVAKFTASPGLSTAD---LKREATICHML 69
            |.:.|:|.|.:|||.||:||||:...:.|::|.||::..|      ||..|   |:|||.||.:|
  Rat     9 FTEEYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKK------LSARDHQKLEREARICRLL 67

  Fly    70 KHPHIVELLETYSSEGMLYMVFEFMEGSDLCFEVVRRAVAGFVYSEAVACHYMRQILEALRYCHE 134
            |||:||.|.::.|.||..|::|:.:.|.:|..::|.|.    .||||.|.|.::|||||:.:||:
  Rat    68 KHPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVARE----YYSEADASHCIQQILEAVLHCHQ 128

  Fly   135 NDILHRDVRPACALLATVDNSAPVKLGGFGSAIQLPGTRETIETHGRVGCPHYMAPEVVTRRLYG 199
            ..::|||::|...|||:....|.|||..||.||::.|.::.  ..|..|.|.|::|||:.:..||
  Rat   129 MGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQA--WFGFAGTPGYLSPEVLRKDPYG 191

  Fly   200 KGCDVWGAGVMLHVLLSGRLPFLGSGV-RLQQSVARGRLSFEAPEWKSISANAKDLVMKMLAANP 263
            |..|:|..||:|::||.|..||..... ||.|.:..|...|.:|||.:::..||||:.|||..||
  Rat   192 KPVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINP 256

  Fly   264 HHRLSITEVLDHPWIRDRDKLQR-THLADTVEELKRYNARRKLKGAV 309
            ..|::..|.|.||||..|..:.. .|..:||:.||::|||||||||:
  Rat   257 SKRITAAEALKHPWISHRSTVASCMHRQETVDCLKKFNARRKLKGAI 303

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CASK	NP_001262811.1	STKc_CASK	8..308	CDD:270996	129/304 (42%)
		S_TKc	12..278	CDD:214567	113/269 (42%)
		L27	347..396	CDD:280918
		L27	406..462	CDD:280918
		PDZ_signaling	493..573	CDD:238492
		SH3_CASK	586..646	CDD:213014
		Guanylate_kin	710..883	CDD:279019
		GuKc	720..883	CDD:214504
Camk2a	XP_038952520.1	STKc_CaMKII	11..302	CDD:270988	128/302 (42%)
Camk2a	XP_038952520.1	CaMKII_AD	357..484	CDD:285524
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0033
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810