DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CASK and pals1a

DIOPT Version :9

Sequence 1:	NP_001262811.1	Gene:	CASK / 42567	FlyBaseID:	FBgn0013759	Length:	929	Species:	Drosophila melanogaster
Sequence 2:	NP_919344.1	Gene:	pals1a / 252845	ZFINID:	ZDB-GENE-020712-1	Length:	703	Species:	Danio rerio

Alignment Length:	772	Identity:	231/772 - (29%)
Similarity:	370/772 - (47%)	Gaps:	134/772 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   178 THGRVGCPHYMAPEVVTRRLY--------GKGCDVWGAGVMLH---------VLLSGRLPFLGSG 225
            ||.....||..|..:.|..:.        |.|.|:...||..|         .|.:..||...|.
Zfish    13 THLHHTPPHMRAAMMTTSHMNGYVTESDGGGGTDIVEEGVQRHREMAVDCPSELGARTLPVRRSA 77

  Fly   226 ----VRLQQSVARGRLSFEAPEWKSISANAKDLVMKMLAANPHHRLSITEVLDHPWIRDRDKLQR 286
                :| ||...|.|...|....:.:..|: .:.:|.|:.||  ::.|    |:|
Zfish    78 QLEKIR-QQQEDRRRREEEGRSRQELDLNS-SMRLKKLSQNP--KVGI----DNP---------- 124

  Fly   287 THLADTVEELKRYNARRKLKGAVQAIAGGTNMDPLYATDADMPITGATDEWADEEAGIEAVQRIL 351
                 |.|:::          .....|||  :..|.|..|.:       |..|....::.||
Zfish   125 -----TFEQME----------GPGGSAGG--LQSLIAPPALL-------ELEDLLMSLKQVQ--- 162

  Fly   352 DCLDDIYSLQD--AHVDADVLRDMLRDNRLHQFLQLFDRIAATV--------VTSNGRAPAAEAV 406
                  :||.|  :..|.:::..:::.....:...:.:.:|..:        :|.:.:..|.|.
Zfish   163 ------HSLNDSQSQEDVELVLQLVQKPDFQKAFSIHNSVAHYMNRPSPPYPLTDHAQTLAQEV- 220

  Fly   407 GRCRDVLEQLSSTSGGNSLGGKYAKEELMRLLAAPHMQALLHSHDVVARDVYGEEALRVTPPPMV 471
                :|:.|.||...|         .||..||:..|||||:.:||.||     |:.:::  .|:|
Zfish   221 ----EVMVQNSSHKEG---------LELSSLLSTSHMQALMMAHDSVA-----EQEMQL--EPLV 265

  Fly   472 PYLNGDELDNVEGGELQHVTRVRLVQFQKNTDEPMGITLKMTEDGRCIVARIMHGGMIHRQATLH 536
            |.:|..|.....|||     .|::|:.:|..|.|:|.|::...|. .:::||:.||...|...||
Zfish   266 PSVNASETLTQWGGE-----TVKIVRIEKAKDIPLGATVRNDMDS-VVISRIVKGGAAERSGLLH 324

  Fly   537 VGDEIREINGQPVQHQSVGQLQRMLREARGSVTFKIVPSYRSAPPPCE---IFVRAQFDYNPLDD 598
            .||||.||||..::.:.|.::..:|.:..|.::|.::||.:...||.:   :.|:|.|||:|.||
Zfish   325 EGDEILEINGVEIRGKDVNEVFDILADMHGVLSFVLIPSAQIKSPPIKETVVHVKAHFDYDPSDD 389

  Fly   599 ELIPCAQAGISFQVGDILQIISKDDHHWWQARLDTVGGS-----AGLIPSPELQEWRIAC-QTVD 657
            ..:||.:.|:.||.||||.|||:||.:||||..|  |..     |||:|....|:.|.|. ||::
Zfish   390 PYVPCRELGLCFQKGDILHIISQDDPNWWQAYRD--GDEDNQPLAGLVPGKSFQQQREAMKQTIE 452

  Fly   658 KTKQEQVNCSIF---GRKKKQCRDKYLAKHNAIFDTLDVVTYEEVVKVPVGDPNFQRKTLVLLGA 719
            :.|:.:....::   ..|||:.:.:|.|..|..||..:::||||:..  ...|..:::.:.|:|.
Zfish   453 EDKEPEKTGKLWCAKKTKKKRKKMQYNANKNDDFDNEEILTYEEMAL--YHQPANRKRPIALIGP 515

  Fly   720 HGVGRRHIKNTLISKYPDKYAYPIPHTTRPAKPEEENGRSYYFVSHDEMMADIGANEYLEYGTHE 784
            ...|:..::..|:|..||::|.|:|||||..:..|.|||.|:|||......|..|.:::|.|..|
Zfish   516 PNCGQNELRQRLLSTEPDRFAGPVPHTTRSRRDAEANGRDYHFVSRQAFEMDSAAGKFIESGEFE 580

  Fly   785 DAMYGTKLDTIRRIHTEGKMAILDVEPQALKILRTAEFTPYVVFIAAPS---LQNIADYDG---- 842
            ...|||..|::|::...||:.:|.|..|:||:||:::..||::|||.||   |:.:...|.
Zfish   581 KNFYGTSTDSVRQVINTGKICLLCVHTQSLKVLRSSDLKPYIIFIAPPSQERLRALLAKDNKNPK 645

  Fly   843 --SLERLAKESEMLRQLYGHFFDLTIVNNDISETIATLETAIDRVHTTPQWVPVSWL 897
              .|..:.:::..:.|.|||.||..|||.|:.::...|...|:::.|.|||||.|||
Zfish   646 PEELRDIIEKAREMEQNYGHLFDAAIVNTDLDKSYQELLRLINKLDTEPQWVPSSWL 702

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CASK	NP_001262811.1	STKc_CASK	8..308	CDD:270996	32/150 (21%)
		S_TKc	12..278	CDD:214567	30/120 (25%)
		L27	347..396	CDD:280918	7/58 (12%)
		L27	406..462	CDD:280918	19/55 (35%)
		PDZ_signaling	493..573	CDD:238492	27/79 (34%)
		SH3_CASK	586..646	CDD:213014	32/64 (50%)
		Guanylate_kin	710..883	CDD:279019	62/181 (34%)
		GuKc	720..883	CDD:214504	60/171 (35%)
pals1a	NP_919344.1	L27_N	150..197	CDD:286189	8/55 (15%)
		PDZ_signaling	282..361	CDD:238492	27/79 (34%)
		SH3_MPP5	377..439	CDD:212969	32/63 (51%)
		Guanylate_kin	506..690	CDD:279019	63/183 (34%)
		GuKc	519..689	CDD:214504	61/169 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910