DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CASK and Magi3

DIOPT Version :9

Sequence 1:	NP_001262811.1	Gene:	CASK / 42567	FlyBaseID:	FBgn0013759	Length:	929	Species:	Drosophila melanogaster
Sequence 2:	NP_620784.3	Gene:	Magi3 / 245903	RGDID:	621362	Length:	1470	Species:	Rattus norvegicus

Alignment Length:	244	Identity:	61/244 - (25%)
Similarity:	92/244 - (37%)	Gaps:	32/244 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   402 AAEAVGRCRDVLEQLSSTSGGNSLGGKYAKEEL-MRLLAAPHMQALLHSHDVVARDV-YGEEALR 464
            |||..||.|...|.:  ...|..:.||..|:.| :...||.:...||    .|.|.: |||:...
  Rat   763 AAEKDGRLRAADELM--CIDGIPVKGKSHKQVLDLMTTAARNGHVLL----TVRRKIFYGEKQPE 821

  Fly   465 VTPPPMV-----PYLNGDELDNVEGGELQHVTRVRLVQFQKNTDEPMG---ITLKMTEDGRCI-- 519
            ...|...     |.||..||......:..:.     |..|:..:|..|   :|.|.......|
  Rat   822 DESPQAFSQSGSPRLNRTELPTRSAPQESYD-----VILQRKENEGFGFVILTSKSKPPPGVIPH 881

  Fly   520 -VARIMHGGMIHRQATLHVGDEIREINGQPVQHQSVGQLQRMLREARGSVTFKIVPSYRSAPPPC 583
             :.|::.|....|...|.|||.|..:|||.:...|...:.:::::|..:||..:|.......||.
  Rat   882 KIGRVIDGSPADRCGRLKVGDHISAVNGQSIVDLSHDNIVQLIKDAGVTVTLTVVAEEEHHGPPS 946

  Fly   584 EIFVRAQ---FDYNPLDDEL---IPCAQAGISFQVGDILQIISKDDHHW 626
            ......|   ..:.|:....   ||..:..:..:||.  .:.|...|.|
  Rat   947 GTNSARQSPALQHRPMGQAQATHIPGDRTALEGEVGK--DVCSSYRHSW 993

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CASK	NP_001262811.1	STKc_CASK	8..308	CDD:270996
		S_TKc	12..278	CDD:214567
		L27	347..396	CDD:280918
		L27	406..462	CDD:280918	18/57 (32%)
		PDZ_signaling	493..573	CDD:238492	22/85 (26%)
		SH3_CASK	586..646	CDD:213014	9/47 (19%)
		Guanylate_kin	710..883	CDD:279019
		GuKc	720..883	CDD:214504
Magi3	NP_620784.3	Interaction with ADRB1 and TGFA. /evidence=ECO:0000269\|PubMed:16316992	18..108
		PDZ_signaling	24..103	CDD:238492
		NK	125..>199	CDD:418433
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	184..266
		HUL4	<211..>373	CDD:227354
		WW	299..329	CDD:238122
		WW	345..375	CDD:238122
		Interaction with PTEN. /evidence=ECO:0000250	413..495
		PDZ	416..496	CDD:214570
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	550..575
		PDZ	578..659	CDD:214570
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	665..700
		PDZ	729..812	CDD:214570	17/54 (31%)
		Interaction with ADGRB1. /evidence=ECO:0000250	729..811		17/53 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	818..847		6/28 (21%)
		PDZ_signaling	851..936	CDD:238492	22/89 (25%)
		Interaction with LPAR2 and GRIN2B. /evidence=ECO:0000250	852..939		23/91 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	939..976		6/36 (17%)
		PDZ_signaling	1023..1101	CDD:238492
		PTZ00112	1115..>1405	CDD:240274
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1124..1146
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1167..1470
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900