DRSC/TRiP Functional Genomics Resources

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Protein Alignment CASK and Camk2d

DIOPT Version :9

Sequence 1:NP_001262811.1 Gene:CASK / 42567 FlyBaseID:FBgn0013759 Length:929 Species:Drosophila melanogaster
Sequence 2:NP_036651.1 Gene:Camk2d / 24246 RGDID:2263 Length:533 Species:Rattus norvegicus


Alignment Length:611 Identity:189/611 - (30%)
Similarity:277/611 - (45%) Gaps:140/611 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly     8 FDDVYELCEVIGKGPFSIVRRCIHRESNQQFAVKIVDVAKFTASPGLSTAD---LKREATICHML 69
            |.|.|:|.|.:|||.||:||||:...:.|::|.||::..|      ||..|   |:|||.||.:|
  Rat    10 FTDEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKK------LSARDHQKLEREARICRLL 68

  Fly    70 KHPHIVELLETYSSEGMLYMVFEFMEGSDLCFEVVRRAVAGFVYSEAVACHYMRQILEALRYCHE 134
            |||:||.|.::.|.||..|:||:.:.|.:|..::|.|.    .||||.|.|.::||||::.:||.
  Rat    69 KHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVARE----YYSEADASHCIQQILESVNHCHL 129

  Fly   135 NDILHRDVRPACALLATVDNSAPVKLGGFGSAIQLPGTRETIETHGRVGCPHYMAPEVVTRRLYG 199
            |.|:|||::|...|||:....|.|||..||.||::.|.::.  ..|..|.|.|::|||:.:..||
  Rat   130 NGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQA--WFGFAGTPGYLSPEVLRKDPYG 192

  Fly   200 KGCDVWGAGVMLHVLLSGRLPFLGSGV-RLQQSVARGRLSFEAPEWKSISANAKDLVMKMLAANP 263
            |..|:|..||:|::||.|..||..... ||.|.:..|...|.:|||.:::..||||:.|||..||
  Rat   193 KPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINP 257

  Fly   264 HHRLSITEVLDHPWIRDRDKL-QRTHLADTVEELKRYNARRKLKGAVQAIAGGTNMDPLYATDAD 327
            ..|::.:|.|.||||..|..: ...|..:||:.||::|||||||||:        :..:.||   
  Rat   258 AKRITASEALKHPWICQRSTVASMMHRQETVDCLKKFNARRKLKGAI--------LTTMLAT--- 311

  Fly   328 MPITGATDEWADEEAGIEAVQRILDCLDDIYSLQDAHVDADVLRDMLRDNRLHQFLQLFDRIAAT 392
                          ....|.:.:|...|.:..                :|:            |.
  Rat   312 --------------RNFSAAKSLLKKPDGVKI----------------NNK------------AN 334

  Fly   393 VVTS---NGRAPAAEAVGRCRDVLEQLSSTSGGNSLGGKYAKEELMRLLAAPHMQALLHSHDVVA 454
            ||||   |...||.|.           .:|...|..|.|.:.|.         ....:...||.|
  Rat   335 VVTSPKENIPTPALEP-----------QTTVIHNPDGNKESTES---------SNTTIEDEDVKA 379

  Fly   455 RDVYGEEALRVTPPPMVPYLNGDELDNVEGGELQHVTRV---RLVQFQK----NTDEPMGITLKM 512
            |.   :|.::||.         ..::.:..|:.:..|::   .|..|:.    |..|.|......
  Rat   380 RK---QEIIKVTE---------QLIEAINNGDFEAYTKICDPGLTAFEPEALGNLVEGMDFHRFY 432

  Fly   513 TEDGRCIVARIMHGGMIHRQATLHVGDEIREI-----------NGQP---------VQHQSVGQL 557
            .|:....:.:.:|..:::....| |||:...|           ||.|         |.|:..|:.
  Rat   433 FENALPKINKPIHTIILNPHVHL-VGDDAACIAYIRLTQYMDGNGMPKTMQSEETRVWHRRDGKW 496

  Fly   558 QRMLREARGSVTFKIVPSYRSAPPPC 583
            |.:.....||.|..|       .|||
  Rat   497 QNIHFHRSGSPTVPI-------KPPC 515

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CASKNP_001262811.1 STKc_CASK 8..308 CDD:270996 132/304 (43%)
S_TKc 12..278 CDD:214567 115/269 (43%)
L27 347..396 CDD:280918 6/48 (13%)
L27 406..462 CDD:280918 9/55 (16%)
PDZ_signaling 493..573 CDD:238492 22/106 (21%)
SH3_CASK 586..646 CDD:213014
Guanylate_kin 710..883 CDD:279019
GuKc 720..883 CDD:214504
Camk2dNP_036651.1 STKc_CaMKII 12..303 CDD:270988 131/302 (43%)
S_TKc 14..272 CDD:214567 115/269 (43%)
Autoinhibitory domain. /evidence=ECO:0000250 283..292 3/8 (38%)
Calmodulin-binding. /evidence=ECO:0000250 291..301 7/9 (78%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 337..375 11/57 (19%)
CaMKII_AD 380..507 CDD:285524 26/139 (19%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0033
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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