DRSC/TRiP Functional Genomics Resources

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Protein Alignment CASK and Dlg2

DIOPT Version :9

Sequence 1:NP_001262811.1 Gene:CASK / 42567 FlyBaseID:FBgn0013759 Length:929 Species:Drosophila melanogaster
Sequence 2:XP_006507830.1 Gene:Dlg2 / 23859 MGIID:1344351 Length:1027 Species:Mus musculus


Alignment Length:750 Identity:182/750 - (24%)
Similarity:299/750 - (39%) Gaps:194/750 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   285 QRTHLADTVEELKRYNARRKLKGAVQAIAGGTNMDPLYATDADMPITGATDEWADEEAG-IEAVQ 348
            :|..:.:||.|:|.:...   ||...:||||.....: ..|..:.:|...|..|.::.| ::...
Mouse   326 RRRPILETVVEIKLFKGP---KGLGFSIAGGVGNQHI-PGDNSIYVTKIIDGGAAQKDGRLQVGD 386

  Fly   349 RILDCLDDIYSLQD-AHVDADVLRDMLRDNRLHQFLQLFDRIAATVVTSNGRAPAAEAVGRCRDV 412
            |:|  :.:.|||:: .|.:|..:   |::.....:|::..  ..|:..::...|.        |:
Mouse   387 RLL--MVNNYSLEEVTHEEAVAI---LKNTSDVVYLKVGK--PTTIYMTDPYGPP--------DI 436

  Fly   413 LEQLSSTSGGNSLGGKYAKEELMRLL--AAPHMQALLHSHDVVARDVYGEEALRVTPPPMVPYLN 475
            ....|.....:.|.|.....|....|  .:|...:.:..| ::..|.|       |.||...|..
Mouse   437 THSYSPPMENHLLSGNNGTLEYKTSLPPISPGRYSPIPKH-MLGEDDY-------TRPPEPVYST 493

  Fly   476 GDEL----------------------------------DNVEGGELQHVTRVR--LVQFQKNTD- 503
            .::|                                  |:......||.|..|  .|..|:... 
Mouse   494 VNKLCDKPASPRHYSPVECDKSFLLSTPYPHYHLGLLPDSDMTSHSQHSTATRQPSVTLQRAISL 558

  Fly   504 --EP-----------MGITLKMTEDGRCI-VARIMHGGMIHRQATLHVGDEIREINGQPVQHQSV 554
              ||           :|..:...|||..| |:.|:.||.......|..||:|..:||..::..|.
Mouse   559 EGEPRKVVLHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASH 623

  Fly   555 GQLQRMLREARGSVTFKIVPSY------------------------------------RSAPPPC 583
            .|....|:.|..:||  |:..|                                    ||     
Mouse   624 EQAAAALKGAGQTVT--IIAQYQPEDYARFEAKIHDLREQMMNHSMSSGSGSLRTNQKRS----- 681

  Fly   584 EIFVRAQFDYNPLDDELIPCAQAGISFQVGDILQIISKDDHHWWQARLDTVGGSA---GLIPSP- 644
             ::|||.|||:...|..:|  ..|:||:.||||.:|:..|..|||||..|:.|.:   |:|||. 
Mouse   682 -LYVRAMFDYDKSKDSGLP--SQGLSFKYGDILHVINASDDEWWQARRVTLDGDSEEMGVIPSKR 743

  Fly   645 --ELQEWRIACQTV----------------DKTKQEQVNCSIFGRKKKQCRDKYLAKHNAIFDTL 691
              |.:| |...:||                ||.|:.    .||.||....::|..::.    :|.
Mouse   744 RVERKE-RARLKTVKFNAKPGVIDSKGSFNDKRKKS----FIFSRKFPFYKNKEQSEQ----ETS 799

  Fly   692 D----------------------VVTYEEVVKVPVGDPNFQRKTLVLLGAHGVGRRHIKNTLISK 734
            |                      :::||.|.:..:   |:.|..::|    |..:..|.:.|||:
Mouse   800 DPEQHVSSNASDSESSCRGQEDLILSYEPVTRQEI---NYTRPVIIL----GPMKDRINDDLISE 857

  Fly   735 YPDKYAYPIPHTTRPAKPEEENGRSYYFV-SHDEMMADIGANEYLEYGTHEDAMYGTKLDTIRRI 798
            :|||:...:||||||.:..|.:||.|:|| |.::|..||..::::|.|.:.|.:|||.:.::|.:
Mouse   858 FPDKFGSCVPHTTRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYGTSVQSVRFV 922

  Fly   799 HTEGKMAILDVEPQALKILRTAEFTPYVVFIAAPSLQNIADYDGSL-ERLAKESE----MLRQLY 858
            ...||..||||...|:|.|:.|:..|..:||...||:.:.:.:..| |..||::.    .|.|.:
Mouse   923 AERGKHCILDVSGNAIKRLQVAQLYPIAIFIKPKSLEPLMEMNKRLTEEQAKKTYDRAIKLEQEF 987

  Fly   859 GHFFDLTIVNNDISETIATLETAIDRVHTTPQWVP 893
            |.:|...:..:.:.:.....:..|:.......|:|
Mouse   988 GEYFTAIVQGDTLEDIYNQCKLVIEEQSGPFIWIP 1022

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CASKNP_001262811.1 STKc_CASK 8..308 CDD:270996 6/22 (27%)
S_TKc 12..278 CDD:214567
L27 347..396 CDD:280918 10/49 (20%)
L27 406..462 CDD:280918 10/57 (18%)
PDZ_signaling 493..573 CDD:238492 26/96 (27%)
SH3_CASK 586..646 CDD:213014 28/65 (43%)
Guanylate_kin 710..883 CDD:279019 56/178 (31%)
GuKc 720..883 CDD:214504 54/168 (32%)
Dlg2XP_006507830.1 L27_1 4..63 CDD:370268
MAGUK_N_PEST 158..240 CDD:371162
PDZ_signaling 241..325 CDD:238492
PDZ_signaling 334..419 CDD:238492 23/93 (25%)
PDZ_assoc 421..488 CDD:371157 14/84 (17%)
PDZ_signaling 562..640 CDD:238492 22/79 (28%)
SH3_DLG2 677..750 CDD:212965 32/81 (40%)
Guanylate_kin 836..1014 CDD:366206 57/181 (31%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0194
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.810

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