DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CASK and PDZD2

DIOPT Version :9

Sequence 1:NP_001262811.1 Gene:CASK / 42567 FlyBaseID:FBgn0013759 Length:929 Species:Drosophila melanogaster
Sequence 2:XP_005248326.1 Gene:PDZD2 / 23037 HGNCID:18486 Length:2873 Species:Homo sapiens


Alignment Length:683 Identity:135/683 - (19%)
Similarity:220/683 - (32%) Gaps:246/683 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly    15 CEVIGKGPFSIVRR--CIHR----ESNQQFAVK----------IVD--VAKFTASPGLSTAD--- 58
            |.|..|  ..:.||  |..:    ||...|:||          ..|  |||..|||.||.:.   
Human  2306 CLVTDK--IKVTRRHYCYEQNWPHESTSFFSVKQRIKSFENLANADRPVAKSGASPFLSVSSKPP 2368

  Fly    59 ------------------------LKREATIC------------HMLKHPHIVELL-------ET 80
                                    |:|..:.|            .|.|.|.|:.|.       ||
Human  2369 IGRRSSGSIVSGSLGHPGDAAARLLRRSLSSCSENQSEAGTLLPQMAKSPSIMTLTISRQNPPET 2433

  Fly    81 YSSEGMLYMVFEFMEGSDLCFEVVRRAVA--GFVYSEAVACHYMRQILEALRYCHENDILHRDVR 143
            .|            :|||   ..:::::.  |...........:::...::|:...:.:....::
Human  2434 SS------------KGSD---SELKKSLGPLGIPTPTMTLASPVKRNKSSVRHTQPSPVSRSKLQ 2483

  Fly   144 PACAL-------LATVDNSAPVKLGGFGSAIQLPGTRETIETHGRVGCPHYMAPEVVTRRLYGKG 201
            ...||       |.:.|.||......|.:.:::...|......|.|.||.             ||
Human  2484 ELRALSMPDLDKLCSEDYSAGPSAVLFKTELEITPRRSPGPPAGGVSCPE-------------KG 2535

  Fly   202 CDVWGAGVMLHVLLSGRLPFLGSGVRLQQSVA------RGRLSFEAPEWKSISANAKDLVMKMLA 260
            .:....|              |||.:...:..      .|..:.:.|..:|.|.|...|   :::
Human  2536 GNRACPG--------------GSGPKTSAAETPSSASDTGEAAQDLPFRRSWSVNLDQL---LVS 2583

  Fly   261 ANPHHRLSITEVLDHPWIRDRDKLQRTHLADTVEELKRYNA-----------RRKLKGAVQAIAG 314
            |....||.  .||....       .::.:...::|.|..:.           |::..|...::||
Human  2584 AGDQQRLQ--SVLSSVG-------SKSTILTLIQEAKAQSENEEDVCFIVLNRKEGSGLGFSVAG 2639

  Fly   315 GTNMDPLYATDADMPITGATDEWADEEAGIEAVQRILDCLDDIYSLQDAHV----DADVLRDMLR 375
            ||:::|...|...:...||..:......|           |.:.|:..|.:    ..:||: :|.
Human  2640 GTDVEPKSITVHRVFSQGAASQEGTMNRG-----------DFLLSVNGASLAGLAHGNVLK-VLH 2692

  Fly   376 DNRLHQFLQLFDRIAATVVTSNGRAPAAEAVGRCRDVLEQLSSTSGGNSL---------GGKYAK 431
            ..:||:        .|.||...|       :.:.|....|...|:.|..|         .|....
Human  2693 QAQLHK--------DALVVIKKG-------MDQPRPSARQEPPTANGKGLLSRKTIPLEPGIENT 2742

  Fly   432 EELMRLLAAPHMQ----------ALLHSHDVVARDVYGEEALRVTPPPMVPYLNGDELDNVEGGE 486
            |:.|: :...|.|          .||.|..|:.|.|...:||                       
Human  2743 EQRMQ-VQQQHSQEGSPRIGRPTVLLGSSAVIRRSVAVHDAL----------------------- 2783

  Fly   487 LQHVTRVRLVQFQKNTDEPMGITL-----KMTEDGRCIVARIMHGGMIHRQATLHVGDEIREING 546
                    .|:..| |...:|::|     .:|.||..::.|:..||...:...:..||||..|||
Human  2784 --------CVEVLK-TSAGLGLSLDGGKSSVTGDGPLVIKRVYKGGAAEQAGIIEAGDEILAING 2839

  Fly   547 QP---VQH-------QSV--GQLQRMLREARGS 567
            :|   :.|       :||  |.:|.::|:.|.|
Human  2840 KPLVGLMHFDAWNIMKSVPEGPVQLLIRKHRNS 2872

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CASKNP_001262811.1 STKc_CASK 8..308 CDD:270996 68/382 (18%)
S_TKc 12..278 CDD:214567 65/341 (19%)
L27 347..396 CDD:280918 11/52 (21%)
L27 406..462 CDD:280918 16/74 (22%)
PDZ_signaling 493..573 CDD:238492 27/92 (29%)
SH3_CASK 586..646 CDD:213014
Guanylate_kin 710..883 CDD:279019
GuKc 720..883 CDD:214504
PDZD2XP_005248326.1 PDZ_signaling 335..416 CDD:238492
PDZ_signaling 589..670 CDD:238492
PDZ_signaling 726..810 CDD:238492
PDZ_signaling 2623..2694 CDD:238492 17/82 (21%)
PDZ 2785..2867 CDD:214570 24/82 (29%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0194
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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