DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CASK and Mpp4

DIOPT Version :9

Sequence 1:	NP_001262811.1	Gene:	CASK / 42567	FlyBaseID:	FBgn0013759	Length:	929	Species:	Drosophila melanogaster
Sequence 2:	NP_001158154.1	Gene:	Mpp4 / 227157	MGIID:	2386681	Length:	654	Species:	Mus musculus

Alignment Length:	650	Identity:	188/650 - (28%)
Similarity:	305/650 - (46%)	Gaps:	122/650 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   339 DEEAGIEAVQRILDCLDDIYSLQDAHVDA-DVLRDMLRDNRLHQFLQLFDRI------AATVVTS 396
            |.|.|:..:.|:|  |.::.......|:. .:|.|:|....|...|:::|.:      .....|:
Mouse    41 DPENGLSGILRLL--LQELSLFYSRDVNGLCLLYDLLHSPWLQALLKVYDCLQRFKEKKLVPDTT 103

  Fly   397 NGRAPAAEAVGRCRDVLEQLSSTSGGNSLGGKYAKEELMRLLAAPHMQALLHSHDVVARDVYGEE 461
            :.:..|.|       |||.|...||...:      :||.::|.|||.:|||.:||.||:..:
Mouse   104 HAQILACE-------VLELLPKASGSPEI------QELRQVLQAPHCKALLSAHDTVAQKDF--- 152

  Fly   462 ALRVTPPPMVPYLNGDELDNVEGGELQHVTRVRLVQFQKNTDEPMGITLKMTE-DGRCIVARIMH 525
                  .|::|.|.    ||:...|    ..:|:|...|| .:|:|.|:|..| .|..:|||::|
Mouse   153 ------EPLLPPLP----DNIPDSE----EAMRIVCLVKN-QQPLGATIKRHEITGDILVARVIH 202

  Fly   526 GGMIHRQATLHVGDEIREINGQPVQHQSVGQLQRMLREARGSVTFKIVPSYRSAPPPCE---IFV 587
            ||::.|...|:.||::.|:||..|:.....|:..:|..:.|::.||::|.  ||||...   ::|
Mouse   203 GGLVERSGLLYAGDKLVEVNGVSVEGLDPEQVIHILAMSCGTIMFKVIPV--SAPPVSSQKMVYV 265

  Fly   588 RAQFDYNPLDDELIPCAQAGISFQVGDILQIISKDDHHWWQAR-LDTVGGSAGLIPS-------- 643
            ||..||.|.:|..|||..||:.|..||||||:.::|..||||| :..:...||||||
Mouse   266 RAMIDYWPQEDPDIPCMDAGLPFLKGDILQIVDQNDALWWQARKISDLTICAGLIPSNHLLKRKQ 330

  Fly   644 -----------------------------------PELQEWRIACQTVDKTKQEQVN------CS 667
                                               .|..|.....:.:.:.|.|.|.      .:
Mouse   331 REFWWSQPYQPHTCLKSTRALSMEEEDSMKIDEKCVEADEETFESEELAEAKDEFVGDGQKFFIA 395

  Fly   668 IFGRKKKQCRDK--YLAKHNAIFDTLDVVT-----YEEVVKVPVGDPNFQRKTLVLLGAHGVGRR 725
            .|.|..:.||.|  :...|.::..:....:     |||||:.. ..|..:.:.:||:|..|||..
Mouse   396 GFRRSMRLCRRKSHFSQLHASLCCSCSCYSAVGAPYEEVVRYQ-RQPADKHRLIVLVGPSGVGVN 459

  Fly   726 HIKNTLISKYPDKYAYPIPHTTRPAKPEEENGRSYYFVSHDEMMADIGANEYLEYGTHEDAMYGT 790
            .::..||...|..:...:|||||..|..|.:||.|::||.:...:.:..::.||||.::..:|||
Mouse   460 ELRRQLIGCNPSCFQSAVPHTTRFPKSYEMDGREYHYVSRETFESLMYGHKMLEYGEYKGHLYGT 524

  Fly   791 KLDTIRRIHTEGKMAILDVEPQALKILRTAEFTPYVVFIAAPSLQNI----------ADY----- 840
            .::.:..:..|||:.|:|:|||.::..||.:..|||:||..|:..::          .||
Mouse   525 SVNAVHAVLDEGKICIMDLEPQDIQSARTRDLKPYVIFIKPPNTSSMRHSRKNAKITTDYYVDMK 589

  Fly   841 --DGSLERLAKESEMLRQLYGHFFDLTIVNNDISETIATLETAIDRVHTTPQWVPVSWLYXQDSE 903
              |..|:.:.:.::.:...:|.|||..|||:::.:....|.:||.:.....||||.:|:  .|:|
Mouse   590 FKDEDLQEMEELAQKMESQFGQFFDHVIVNDNLQDACGQLLSAIQKAQEELQWVPEAWV-SPDTE 653

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CASK	NP_001262811.1	STKc_CASK	8..308	CDD:270996
		S_TKc	12..278	CDD:214567
		L27	347..396	CDD:280918	10/55 (18%)
		L27	406..462	CDD:280918	19/55 (35%)
		PDZ_signaling	493..573	CDD:238492	29/80 (36%)
		SH3_CASK	586..646	CDD:213014	31/103 (30%)
		Guanylate_kin	710..883	CDD:279019	57/189 (30%)
		GuKc	720..883	CDD:214504	54/179 (30%)
Mpp4	NP_001158154.1	L27	<66..100	CDD:197794	6/33 (18%)
		L27	108..154	CDD:280918	21/67 (31%)
		PDZ_signaling	171..250	CDD:238492	29/79 (37%)
		SH3_MPP4	264..324	CDD:212967	31/59 (53%)
		Guanylate_kin	446..636	CDD:279019	58/189 (31%)
		GuKc	454..637	CDD:214504	55/182 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810