Protein Alignment CASK and magu-3

DIOPT Version :9

• Sequence 1: NP_001262811.1
• Gene: CASK / 42567
• FlyBaseID: FBgn0013759
• Length: 929
• Species: Drosophila melanogaster
• Sequence 2: NP_491260.2
• Gene: magu-3 / 183676
• WormBaseID: WBGene00016841
• Length: 479
• Species: Caenorhabditis elegans
• Alignment Length: 561
• Identity: 139/561 - (24%)
• Similarity: 218/561 - (38%)
• Gaps: 129/561 - (22%)

  Fly   374 LRDNR------LHQFLQLFDRIAATVVTSNGRAPAAEAVGRCRDVLEQLSSTSGGNSLGGKYAKE 432
            ||.|.      ||..|:..:.|.    ..||:...|:            |:.|.|.|...|..||
 Worm    10 LRSNAENLSRCLHVLLEKIENIE----KKNGKEQDAD------------STKSNGTSSSNKDGKE 58

  Fly   433 ELMRLLAAPHMQ---------ALLHSHDVVARDVYGEEALRVTPPPMVPYLNGDELDNVEGGELQ 488
            :..::......:         ..:.:..|:....:...||....|.|.|.|......|.....:
 Worm    59 KFEQVEIEEKTEIDPKTGLKKRTIVTERVLTTKTFHALALDGPSPTMTPILRSSGTKNHNYAPI- 122

  Fly   489 HVTRVRLVQFQKNTDEPMGITLKMTED-GRCIVARI-MHGGM-----IHRQAT--LHVGDEIREI 544
            |.:.:.|.|:|..         |.|.| |:.....: .|||.     |:.::.  |..||.|.::
 Worm   123 HQSAILLPQYQSR---------KTTVDAGQLTQVEVEKHGGQLVVTKINEKSNYDLKPGDVITQV 178

  Fly   545 NGQPVQHQSVGQLQRMLREARGSVTFKIVPS-YRSAPPPCEIFVRAQFDYNPLDDELIPCAQAGI 608
            :|:.|..::      .:...:|.|...:.|: ...||..   |.|.|..|:...|...||....:
 Worm   179 DGKDVYFRA------DIENLKGKVELTVEPAGIHCAPAN---FHRVQDTYSSHIDVDRPCLWLDL 234

  Fly   609 SFQVGDILQIISKDDHHWWQARLDTVGG--SAGLIPSPELQEWRIACQTVDKTKQEQVNCSIFGR 671
            ....||::||:|||: .|.|.|  .:|.  ..|.:|:.
 Worm   235 EVNPGDVIQILSKDE-KWMQVR--KLGDLTQVGYLPTS--------------------------- 269

  Fly   672 KKKQCRDKYLAKHNAIFDTLDVVTYEEV-VKVPVGDPNFQRKTLVLLGAHGVGRRHIKNTLISKY 735
                                  :|.|:| :..|.|     |:|||||||.|.|||.||:.|:...
 Worm   270 ----------------------LTMEKVSMLCPFG-----RRTLVLLGAVGTGRRDIKSMLLRLA 307

  Fly   736 PDKYAYPIPHTTRPAKPEEENGRSYYFVSHDEMMADIGANEYLEYGTHEDAMYGTKLDTIRRIHT 800
            |..::..:|.|:|..:|.|..||.|.||..:|:...|.....:|:|..:..:|||..|::|....
 Worm   308 PHYFSTIVPLTSRAQRPGEVEGREYQFVRKEEIYQKIREGGMVEWGELDSQLYGTSADSVRNEIR 372

  Fly   801 EGKMAILDVEPQALKILRTAEFTPYVVFIAAPSLQNIADYD---------GSLERLAKESEMLRQ 856
            .|:|.:||..||::..|..|||.|:||.:..|.::.....:         |.|:.:..||..:..
 Worm   373 SGRMCVLDAAPQSVNYLYNAEFMPFVVHVVPPPIEEFTQLEAVRRTHRTQGQLQSICDESAKIGL 437

  Fly   857 LYGHFFDLTIVNNDISETIATLETAIDRVHTTPQWVPVSWL 897
            .......||:||.:|..|...|..:::.:....||||.||:
 Worm   438 ECKSKIHLTLVNRNIDVTFKRLVDSLETLRYETQWVPHSWM 478

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CASK	NP_001262811.1	STKc_CASK	8..308	CDD:270996
		S_TKc	12..278	CDD:214567
		L27	347..396	CDD:280918	7/27 (26%)
		L27	406..462	CDD:280918	8/64 (13%)
		PDZ_signaling	493..573	CDD:238492	19/88 (22%)
		SH3_CASK	586..646	CDD:213014	20/61 (33%)
		Guanylate_kin	710..883	CDD:279019	60/181 (33%)
		GuKc	720..883	CDD:214504	52/171 (30%)
magu-3	NP_491260.2	PDZ	147..204	CDD:381812	13/62 (21%)
		SH3	218..268	CDD:388381	16/52 (31%)
		Guanylate_kin	282..464	CDD:366206	61/186 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	3	2.770