DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CASK and lin-2

DIOPT Version :9

Sequence 1:	NP_001262811.1	Gene:	CASK / 42567	FlyBaseID:	FBgn0013759	Length:	929	Species:	Drosophila melanogaster
Sequence 2:	NP_001024587.1	Gene:	lin-2 / 181400	WormBaseID:	WBGene00002991	Length:	961	Species:	Caenorhabditis elegans

Alignment Length:	976	Identity:	454/976 - (46%)
Similarity:	610/976 - (62%)	Gaps:	102/976 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 EDEILFDDVYELCEVIGKGPFSIVRRCIHRESNQQFAVKIVDVAKFTASPGLSTADLKREATICH 67
            |..:|.|:...:.:||.:||||.|.|.:|..||::|.::.:::..|....||...::..|..||.
Worm     8 ESNLLLDEQLSIRDVIEQGPFSNVYRILHGPSNRKFLLRSINLNLFRQHTGLGFEEIDEEIRICQ 72

  Fly    68 MLKHPHIVELLETYSSEGMLYMVFEFMEGSDLCFEVVRRAVAGFVYSEAVACHYMRQILEALRYC 132
            .|:||:|..|.:|.:|....:::||.|||:|:|||:|:||..|||:||.|..||.||:|:||.||
Worm    73 NLQHPYICRLEKTINSVHYRHIIFENMEGNDICFEIVQRASNGFVFSEYVVSHYTRQLLDALDYC 137

  Fly   133 HENDILHRDVRPACALLATVDNSAPVKLGGFGSAIQLPGTRETIETHGRVGCPHYMAPEVVTRRL 197
            |...|:||||||...:||:.|.|||:||.|||.|..|.....::.. ||||.|.:||||:|.:..
Worm   138 HTRKIVHRDVRPHNLVLASKDTSAPLKLCGFGVAKDLSEIGGSMAC-GRVGVPQFMAPEIVRKDR 201

  Fly   198 YGKGCDVWGAGVMLHVLLSGRLPFLGSGVRLQQSVARGRLSFEAPEWKSISANAKDLVMKMLAAN 262
            .....|:|.:||:|.:||:|||||.||...:.:.:.:..:..:. ...:||.:|::||.:||.|:
Worm   202 VSCSSDIWSSGVVLFLLLAGRLPFSGSTSDIYERIMQTDVDVDG-YMPNISESARNLVRRMLNAD 265

  Fly   263 PHHRLSITEVLDHPWIRDRDKL-QRTHLADTVEELKRYNARRKLKGAVQAIAGGTNMDPLYATDA 326
            |..|:|..|.|:|.||||::.: .|.|:.|.:::::|||..||||..|.:.......|.. ....
Worm   266 PSKRISAKEALNHEWIRDKEHMASRKHMNDVIDQMRRYNESRKLKSNVLSAVNSGRFDET-TPRQ 329

  Fly   327 DMPITGATD------------EWADEEAG-------IEAVQRILDCLDDIYSLQDAH---VDADV 369
            |.|.|...|            |.:..:|.       :....::|..||.|.||.|.:   ..:..
Worm   330 DTPQTAFVDGSSPGGDCCHRGESSSNDAAEPPADKDLSGAYKVLGSLDAINSLLDPNSYKPGSTT 394

  Fly   370 LRDMLRDNRLHQFLQLFDRIAA--------TVVTSNGRAPAAEAVGRCRDVLEQLSSTSGGNSLG 426
            .:.:..|..:...|:|:|:|.|        .|.||..|          ::.|.|:...     ||
Worm   395 FQKIHDDGSVRNLLRLYDKIKALPCEPVVTEVDTSTLR----------KETLNQIDGL-----LG 444

  Fly   427 GKYAKEELMRLLAAPHMQALLHSHDVVA---RDVYGE-------EALRVTPPPMVPYLNGDELD- 480
            ......||.:||.:||:.:.:.:.|||.   ||...|       |...|:..|...||||..|.
Worm   445 PSPEALELRQLLNSPHLASCVQALDVVVCEIRDPKNEASGSGDKEGNCVSSDPAPAYLNGGVLPL 509

  Fly   481 --NVEGGELQH--------------------VTRVRLVQFQKNTDEPMGITLKMTEDGRCIVARI 523
              ...|...:|                    ::|:|||||||:|.||||||||:.|||||.||||
Worm   510 GAQRAGTSFEHFNQSAVHTSYDEEEEELYDCMSRLRLVQFQKDTQEPMGITLKVNEDGRCFVARI 574

  Fly   524 MHGGMIHRQATLHVGDEIREINGQPVQHQSVGQLQRMLREARGSVTFKIVPSYRSAPPPCEIFVR 588
            |||||||||||||||||||||||..|.::||..||.|||:|||.|||||:||||||||.||||||
Worm   575 MHGGMIHRQATLHVGDEIREINGMSVANRSVESLQEMLRDARGQVTFKIIPSYRSAPPACEIFVR 639

  Fly   589 AQFDYNPLDDELIPCAQAGISFQVGDILQIISKDDHHWWQAR----LDTVGGS-----------A 638
            |||||.|..|:||||.||||.|:.|||||:||||||:|||||    ..::|.|           |
Worm   640 AQFDYEPSQDDLIPCPQAGIPFKTGDILQVISKDDHNWWQARFVSSFPSIGNSSNAQRSNQQQVA 704

  Fly   639 GLIPSPELQEWRIACQTVDKTKQE-QVNCSIFGRKKKQCRDKYLAKHNAIFDTLDVVTYEEVVKV 702
            ||||||||||||.||..::::|.. ..:|..|.:|||....|||.||:|:||.||:||||||:::
Worm   705 GLIPSPELQEWRTACLAMERSKNTCNTHCMWFNKKKKYYTTKYLQKHSALFDQLDLVTYEEVMRL 769

  Fly   703 PVGDPNFQRKTLVLLGAHGVGRRHIKNTLISKYPDKYAYPIPHTTRPAKPEEENGRSYYFVSHDE 767
                ..::||||||||||||||||||||||.::|:::||||||||||.:.:|.:|:.||||::::
Worm   770 ----SQYRRKTLVLLGAHGVGRRHIKNTLIHRHPNRFAYPIPHTTRPPRKDEVDGKHYYFVTNEQ 830

  Fly   768 MMADIGANEYLEYGTHEDAMYGTKLDTIRRIHTEGKMAILDVEPQALKILRTAEFTPYVVFIAAP 832
            |||||..||||||||||::||||||:|||.||..||:|||||||||||:|||||::|:|||||||
Worm   831 MMADIQNNEYLEYGTHEESMYGTKLETIRNIHKSGKIAILDVEPQALKVLRTAEYSPFVVFIAAP 895

  Fly   833 SLQNIADYDGSLERLAKESEMLRQLYGHFFDLTIVNNDISETIATLETAIDRVHTTPQWVPVSWL 897
            :||.:.|.|||||:|..||::|||.:||.||..|.|:||.:|||.||..::::...|||:||:|:
Worm   896 NLQGMQDPDGSLEKLLNESDVLRQAFGHLFDFIITNSDIDDTIAQLERLVEKLPAYPQWLPVTWV 960

  Fly   898 Y 898
            |
Worm   961 Y 961

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CASK	NP_001262811.1	STKc_CASK	8..308	CDD:270996	126/300 (42%)
		S_TKc	12..278	CDD:214567	111/265 (42%)
		L27	347..396	CDD:280918	14/59 (24%)
		L27	406..462	CDD:280918	16/65 (25%)
		PDZ_signaling	493..573	CDD:238492	63/79 (80%)
		SH3_CASK	586..646	CDD:213014	44/74 (59%)
		Guanylate_kin	710..883	CDD:279019	118/172 (69%)
		GuKc	720..883	CDD:214504	109/162 (67%)
lin-2	NP_001024587.1	PKc_like	13..312	CDD:304357	126/300 (42%)
		S_TKc	19..281	CDD:214567	111/263 (42%)
		L27	372..422	CDD:280918	13/49 (27%)
		L27	431..478	CDD:280918	15/61 (25%)
		PDZ	546..624	CDD:278991	62/77 (81%)
		SH3_MPP1-like	637..712	CDD:212968	44/74 (59%)
		Guanylate_kin	773..948	CDD:279019	118/174 (68%)
		GuKc	783..947	CDD:214504	109/163 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160167046
Domainoid	1	1.000	255	1.000	Domainoid score	I1105
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2736
Inparanoid	1	1.050	809	1.000	Inparanoid score	I247
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49156
OrthoDB	1	1.010	-	-		D364535at33208
OrthoFinder	1	1.000	-	-		FOG0006854
OrthoInspector	1	1.000	-	-		oto18904
orthoMCL	1	0.900	-	-		OOG6_105717
Panther	1	1.100	-	-	LDO	PTHR23122
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2610
SonicParanoid	1	1.000	-	-		X4946
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	15	14.940