DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CASK and dlg-1

DIOPT Version :9

Sequence 1:NP_001262811.1 Gene:CASK / 42567 FlyBaseID:FBgn0013759 Length:929 Species:Drosophila melanogaster
Sequence 2:NP_001024431.1 Gene:dlg-1 / 180819 WormBaseID:WBGene00001006 Length:967 Species:Caenorhabditis elegans


Alignment Length:779 Identity:184/779 - (23%)
Similarity:301/779 - (38%) Gaps:217/779 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly   217 GRLPFLGSGVRLQQSVARGRL-----SFEAPEWKSISANAKDLVMKMLAANP------HH----R 266
            |...:|.|||  ..||:.|.|     |..||                  .:|      ||    :
 Worm   302 GSTSYLRSGV--TPSVSAGNLQHAIHSPSAP------------------IHPPPPPPVHHGSLSQ 346

  Fly   267 LSITEVLDHPWIRDRDKLQRTHLADTVEELKRYNARRKLKGAVQAIAGGTNMDPLYATDADMPIT 331
            ||:.:.        |.....|.:.|.|         :..:|...:||||...:.:.. |.|:.:|
 Worm   347 LSVGQY--------RSTRPNTSVIDLV---------KGARGLGFSIAGGQGNEHVKG-DTDIYVT 393

  Fly   332 GATDEWADEEAG-IEAVQRILDCLDDIYSL-QDAHVDA-DVLRDMLRDNRLHQFLQ-----LFDR 388
            ...:|.|.|..| :....:||:.  |.:|| ...|.:| :||::  ..||:...:|     :|:.
 Worm   394 KIIEEGAAELDGRLRVGDKILEV--DHHSLINTTHENAVNVLKN--TGNRVRLLIQQGTGAIFND 454

  Fly   389 IAA---TVVTSNGRAPAAEAVGRCRDVLEQLSSTSGGNSLGGKYAKEELMRLLAAPHMQALLHSH 450
            .|:   ...|...|..:.:...|.:  :...|..|.|..|...|:.:..:.:...|.        
 Worm   455 SASQQFMPTTPILRPSSVQDYNRSQ--MGSQSHLSYGGPLNTSYSSQAPIAIPLEPR-------- 509

  Fly   451 DVVARDVYGEEALRVTPPPMVPYLNGDELDNVEGGELQHVTRVRLVQFQKNTDEPMGITLKMTED 515
                            |..:|...||... |:.|||               .:||:.|:.     
 Worm   510 ----------------PVQLVKGQNGLGF-NIVGGE---------------DNEPIYISF----- 537

  Fly   516 GRCIVARIMHGGMIHRQATLHVGDEIREINGQPVQHQSVGQLQRMLREARGSVTFKIVPSYRSAP 580
                   ::.||:......:..||.:.|:||..:::.:..:....||.|...|...:  .||  |
 Worm   538 -------VLPGGVADLSGNVKTGDVLLEVNGVVLRNATHKEAAEALRNAGNPVYLTL--QYR--P 591

  Fly   581 PPCEIF--------------------------VRAQFDYNP-LDDELIPCAQAGISFQVGDILQI 618
            ...:||                          |||.|||:| .::.:.|....|  |..||||.|
 Worm   592 QEYQIFESKIEKLRNDVIAQSRMGTLSRKSEYVRALFDYDPSRENSVAPHRSMG--FNYGDILHI 654

  Fly   619 ISKDDHHWWQARLDTVGG---SAGLIPSPELQEWRIACQTVDKTKQEQVNCS------------- 667
            |:..|..||.||.....|   :.|:|||.:..|.|      ::.:::|||.:             
 Worm   655 INSSDDEWWTARKVHENGEETAEGVIPSKKRVEKR------ERLRRKQVNFNSGSQSLGRNSSTT 713

  Fly   668 ------------IFGRK----KKQCRDKYLAKHNAIFDTLDVVTYEEVVKVPVGDPNFQRKTLVL 716
                        .|.||    |...|...|.:.::......|.:|:.|.:..:   |:.|..::|
 Worm   714 GLENRRGSRSQLSFSRKFPFVKSTDRLNDLNEESSNVAEEPVWSYQAVEQQAI---NYVRPVIIL 775

  Fly   717 LGAHGVGRRHIKNTLISKYPDKYAYPIPHTTRPAKPEEENGRSYYFVSHDEMMADIGANEYLEYG 781
                |..:..|.:.|:::.|.|::..:|||:||.:..|.|||.||||:...|..|:..|.::|.|
 Worm   776 ----GALKDRINDELVNRDPSKFSSCVPHTSRPPREGEVNGRDYYFVNKHNMEEDVKNNLFIEAG 836

  Fly   782 THEDAMYGTKLDTIRRIHTEGKMAILDVEPQALKILRT-AEFTPYVVFIAAPSLQNIADYDGSL- 844
            ..::.:|||.:.::|.:..:|:..||||...|::.|:: |...|..:||...|.|.|.:.|..| 
 Worm   837 QFQNNLYGTSIQSVRDVANQGRHCILDVSGNAIRRLQSNANIQPISIFIKPSSAQQILELDSQLA 901

  Fly   845 ------------ERLAKES--EMLRQLYGHFFDLTIVN-NDISETIATLETAIDRVHTTPQWVP 893
                        |..|:.|  ..:.|.:|..|...|.| :..::.::.:.:.|.|...||.|||
 Worm   902 TNRQDDRAMSGEEAQAQYSRCHRIEQTFGDLFTQEISNVHSANDVLSKVYSIISRESQTPIWVP 965

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CASKNP_001262811.1 STKc_CASK 8..308 CDD:270996 21/105 (20%)
S_TKc 12..278 CDD:214567 17/75 (23%)
L27 347..396 CDD:280918 14/58 (24%)
L27 406..462 CDD:280918 7/55 (13%)
PDZ_signaling 493..573 CDD:238492 14/79 (18%)
SH3_CASK 586..646 CDD:213014 27/89 (30%)
Guanylate_kin 710..883 CDD:279019 53/189 (28%)
GuKc 720..883 CDD:214504 51/179 (28%)
dlg-1NP_001024431.1 L27_1 7..63 CDD:312556
PDZ 199..289 CDD:214570
PDZ_signaling 361..445 CDD:238492 25/97 (26%)
PDZ 507..591 CDD:214570 25/139 (18%)
SH3_DLG-like 623..684 CDD:212795 26/62 (42%)
GuKc 776..944 CDD:214504 51/167 (31%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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