DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CASK and DLG4

DIOPT Version :9

Sequence 1:	NP_001262811.1	Gene:	CASK / 42567	FlyBaseID:	FBgn0013759	Length:	929	Species:	Drosophila melanogaster
Sequence 2:	XP_011522001.1	Gene:	DLG4 / 1742	HGNCID:	2903	Length:	797	Species:	Homo sapiens

Alignment Length:	807	Identity:	188/807 - (23%)
Similarity:	312/807 - (38%)	Gaps:	228/807 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   206 GAGVMLHVLLSGRLPFLGSGVRLQQSVARGRLSFEAP----------EWKSISANAKDLVMKMLA 260
            |.||:.|..||   ||..:    ...|.....:.|||          |::.|:....:..:....
Human    95 GHGVVGHAHLS---PFKAN----SPPVIVNTDTLEAPGYVNGTEGEMEYEEITLERGNSGLGFSI 152

  Fly   261 A----NPH----HRLSITEVLDHP-----------------WIRDRDKLQRTHLADTVEELKR-- 298
            |    |||    ..:.||:::  |                 ::.:.|..:.||.| .||.||.
Human   153 AGGTDNPHIGDDPSIFITKII--PGGAAAQDGRLRVNDSILFVNEVDVREVTHSA-AVEALKEAG 214

  Fly   299 -----YNARRK--------------LKGAVQAIAGGTNM------DPLYATDADMPITGATDEWA 338
                 |..|||              .||...:||||...      :.:|.|..   |.|..   |
Human   215 SIVRLYVMRRKPPAEKVMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKI---IEGGA---A 273

  Fly   339 DEEAGIEAVQRILDCLDDIYSLQDAHVDADVLRDMLRDNRLHQFLQLFDRIAATVV------TSN 397
            .::..::...:||            .|::..|.|::.::.:......:|.:...|.      .|:
Human   274 HKDGRLQIGDKIL------------AVNSVGLEDVMHEDAVAALKNTYDVVYLKVAKPSNAYLSD 326

  Fly   398 GRAPAAEAVGRCRDVLEQLSSTSGGNSLGGKYAKEELMRLLAAPHMQALLHSHDVVARDVYGEEA 462
            ..||........:.:..::|.:|   .||..|   .......:|      ..:..||:|:.|||.
Human   327 SYAPPDITTSYSQHLDNEISHSS---YLGTDY---PTAMTPTSP------RRYSPVAKDLLGEED 379

  Fly   463 LRVTPPPMVPYLNGDELD-NVEGGELQHVTRVRLVQFQKNTDEPMGITLKMTEDGRCI-VARIMH 525
            :...|..:|.:.....|. |:.||                            |||..| ::.|:.
Human   380 IPREPRRIVIHRGSTGLGFNIVGG----------------------------EDGEGIFISFILA 416

  Fly   526 GGMIHRQATLHVGDEIREINGQPVQHQSVGQLQRMLREARGSVTFKIVPSYR------------- 577
            ||.......|..||:|..:||..:::.|..|....|:.|..:||  |:..|:
Human   417 GGPADLSGELRKGDQILSVNGVDLRNASHEQAAIALKNAGQTVT--IIAQYKPEEYSRFEAKIHD 479

  Fly   578 -----------------SAPPPCEIFVRAQFDYNPLDDELIPC---AQAGISFQVGDILQIISKD 622
                             .:.|....::||.|||:...|    |   :|| :||:.||:|.:|...
Human   480 LREQLMNSSLGSGTASLRSNPKRGFYIRALFDYDKTKD----CGFLSQA-LSFRFGDVLHVIDAS 539

  Fly   623 DHHWWQAR---LDTVGGSAGLIPSP---ELQEW-RIACQTVDKTKQEQVNCSIFGRKKKQCRDKY 680
            |..|||||   .|:.....|.|||.   |.:|| |:..:....:...|      ||:.
Human   540 DEEWWQARRVHSDSETDDIGFIPSKRRVERREWSRLKAKDWGSSSGSQ------GRED------- 591

  Fly   681 LAKHNAIFDTLDVVTYEEVVKVPVGDPNFQRKTLVLLGAHGVGRRHIKNTLISKYPDKYAYPIPH 745
                       .|::||.|.::.|   ::.|..::|    |..:....:.|:|::|||:...:||
Human   592 -----------SVLSYETVTQMEV---HYARPIIIL----GPTKDRANDDLLSEFPDKFGSCVPH 638

  Fly   746 TTRPAKPEEENGRSYYFV-SHDEMMADIGANEYLEYGTHEDAMYGTKLDTIRRIHTEGKMAILDV 809
            ||||.:..|.:||.|:|| |.::|..||.|::::|.|.:...:|||.:.::|.:..:||..||||
Human   639 TTRPKREYEIDGRDYHFVSSREKMEKDIQAHKFIEAGQYNSHLYGTSVQSVREVAEQGKHCILDV 703

  Fly   810 EPQALKILRTAEFTPYVVFIAAPSLQNIADYDGSLERLAKE--------SEMLRQLYGHFFDLTI 866
            ...|::.|:.|...|..:||...||:|:.:.:   :|:.:|        :..|.|.:...|...:
Human   704 SANAVRRLQAAHLHPIAIFIRPRSLENVLEIN---KRITEEQARKAFDRATKLEQEFTECFSAIV 765

  Fly   867 VNNDISETIATLETAIDRVHTTPQWVP 893
            ..:...|....::..|:.:.....|||
Human   766 EGDSFEEIYHKVKRVIEDLSGPYIWVP 792

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CASK	NP_001262811.1	STKc_CASK	8..308	CDD:270996	34/157 (22%)
		S_TKc	12..278	CDD:214567	21/106 (20%)
		L27	347..396	CDD:280918	7/54 (13%)
		L27	406..462	CDD:280918	11/55 (20%)
		PDZ_signaling	493..573	CDD:238492	19/80 (24%)
		SH3_CASK	586..646	CDD:213014	26/68 (38%)
		Guanylate_kin	710..883	CDD:279019	52/181 (29%)
		GuKc	720..883	CDD:214504	50/171 (29%)
DLG4	XP_011522001.1	L27	<26..49	CDD:413432
		MAGUK_N_PEST	54..137	CDD:402306	13/48 (27%)
		PDZ	138..222	CDD:395476	17/86 (20%)
		PDZ	233..317	CDD:395476	17/101 (17%)
		PDZ_assoc	318..385	CDD:402299	15/78 (19%)
		PDZ	383..467	CDD:214570	27/113 (24%)
		SH3_DLG4	503..568	CDD:212963	26/69 (38%)
		Guanylate_kin	606..784	CDD:395500	53/184 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810