DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CASK and DLG3

DIOPT Version :9

Sequence 1:	NP_001262811.1	Gene:	CASK / 42567	FlyBaseID:	FBgn0013759	Length:	929	Species:	Drosophila melanogaster
Sequence 2:	XP_006724688.1	Gene:	DLG3 / 1741	HGNCID:	2902	Length:	849	Species:	Homo sapiens

Alignment Length:	878	Identity:	215/878 - (24%)
Similarity:	332/878 - (37%)	Gaps:	216/878 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   154 NSAPVKLGGFGS--------AIQLPGTRETIETHGR-VG-CPHYMAPEVVTRRLYGKGCDVW--- 205
            |.|....||:.|        |...|.|:..:...|| || .|....|...|.:|.|.|...|
Human    45 NGASAGYGGYSSQTLPSQAGATPTPRTKAKLIPTGRDVGPVPPKPVPGKSTPKLNGSGPSWWPEC 109

  Fly   206 ------------GAGVMLH----VLLSGRLPFLGSGVRLQQSVARGRLSFEAPEWKSISANAKDL 254
                        |:..|..    ||..|     .||  |..|:|.|..:...|:...|      .
Human   110 TCTNRDWYEQVNGSDGMFKYEEIVLERG-----NSG--LGFSIAGGIDNPHVPDDPGI------F 161

  Fly   255 VMKML---AANPHHRLSITEVLDHPWIRDRDKLQRTHLADTVEELK------RYNARRKL----- 305
            :.|::   ||....||.:.:.:..  :.:.|..:..| :..||.||      |...||:.
Human   162 ITKIIPGGAAAMDGRLGVNDCVLR--VNEVDVSEVVH-SRAVEALKEAGPVVRLVVRRRQPPPET 223

  Fly   306 ----------KGAVQAIAGGTNMDPLYATDADMPITGATDEWADEEAGIEAVQRILDCLDDIYSL 360
                      ||...:||||.....: ..|..:.||...:..|.:
Human   224 IMEVNLLKGPKGLGFSIAGGIGNQHI-PGDNSIYITKIIEGGAAQ-------------------- 267

  Fly   361 QDAHVDADVLRDMLRDNRLHQFLQLFDRIAATVVTSNGRAPAAEAVGRCR---DVLEQLSSTSGG 422
                          :|.|    ||:.||:.|...|:.......|||...:   |::....:..|.
Human   268 --------------KDGR----LQIGDRLLAVNNTNLQDVRHEEAVASLKNTSDMVYLKVAKPGS 314

  Fly   423 NSLGGKYAKEELMRLLAAPHMQALLHSHDVVARDVYG-----EEALRVTPPPMVPYLNGDELDNV 482
            ..|...||..:.     |....||..:| :......|     |..:....||.||......:...
Human   315 LHLNDMYAPPDY-----ASTFTALADNH-ISHNSSLGYLGAVESKVSYPAPPQVPPTRYSPIPRH 373

  Fly   483 EGGELQHVTRVRLVQFQKNTDEPMGITLKMTEDGRCI-VARIMHGGMIHRQATLHVGDEIREING 546
            ...|.......|.:...|.: ..:|..:...|||..| |:.|:.||.......|..||.|..:||
Human   374 MLAEEDFTREPRKIILHKGS-TGLGFNIVGGEDGEGIFVSFILAGGPADLSGELRRGDRILSVNG 437

  Fly   547 QPVQHQSVGQLQRMLREARGSVTFKIVPSYRSAPPPCE--------------------------- 584
            ..:::.:..|....|:.|..|||  ||..||    |.|
Human   438 VNLRNATHEQAAAALKRAGQSVT--IVAQYR----PEEYSRFESKIHDLREQMMNSSMSSGSGSL 496

  Fly   585 -------IFVRAQFDYNPLDDELIPCAQAGISFQVGDILQIISKDDHHWWQARLDTVGGSA---G 639
                   ::|||.|||:...|..:|  ..|:||..||||.:|:..|..||||||.|..|.:   |
Human   497 RTSEKRSLYVRALFDYDRTRDSCLP--SQGLSFSYGDILHVINASDDEWWQARLVTPHGESEQIG 559

  Fly   640 LIPSPELQE--WRIACQTVD---KTKQEQVNCSIFGRKKKQCR-----DKYLAKHN--------- 685
            :|||.:..|  .|...:||.   :|...:.|.||..::||..|     ..|.:|.|
Human   560 VIPSKKRVEKKERARLKTVKFHARTGMIESNRSIKTKRKKSFRLSRKFPFYKSKENMAQESSIQE 624

  Fly   686 --AIFDTLD-----------VVTYEEVVKVPVGDPNFQRKTLVLLGAHGVGRRHIKNTLISKYPD 737
              ...:|.|           :::||.|.:..:   ::.|..::|    |..:..:.:.|||::|.
Human   625 QGVTSNTSDSESSSKGQEDAILSYEPVTRQEI---HYARPVIIL----GPMKDRVNDDLISEFPH 682

  Fly   738 KYAYPIPHTTRPAKPEEENGRSYYF-VSHDEMMADIGANEYLEYGTHEDAMYGTKLDTIRRIHTE 801
            |:...:||||||.:..|.:|:.|:| ||.::|..||..|:::|.|...|.:|||.:.::|.:...
Human   683 KFGSCVPHTTRPRRDNEVDGQDYHFVVSREQMEKDIQDNKFIEAGQFNDNLYGTSIQSVRAVAER 747

  Fly   802 GKMAILDVEPQALKILRTAEFTPYVVFIAAPSLQNIAD------YDGSLERLAKESEMLRQLYGH 860
            ||..||||...|:|.|:.|:..|..:||...|::.:.:      |: ...::..::..|.|.:|.
Human   748 GKHCILDVSGNAIKRLQQAQLYPIAIFIKPKSIEALMEMNRRQTYE-QANKIYDKAMKLEQEFGE 811

  Fly   861 FFDLTIVNNDISETIATLETAIDRVHTTPQWVP 893
            :|...:..:.:.|....::..|:.......|||
Human   812 YFTAIVQGDSLEEIYNKIKQIIEDQSGHYIWVP 844

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CASK	NP_001262811.1	STKc_CASK	8..308	CDD:270996	47/206 (23%)
		S_TKc	12..278	CDD:214567	37/155 (24%)
		L27	347..396	CDD:280918	7/48 (15%)
		L27	406..462	CDD:280918	12/63 (19%)
		PDZ_signaling	493..573	CDD:238492	23/80 (29%)
		SH3_CASK	586..646	CDD:213014	29/62 (47%)
		Guanylate_kin	710..883	CDD:279019	51/179 (28%)
		GuKc	720..883	CDD:214504	49/169 (29%)
DLG3	XP_006724688.1	MAGUK_N_PEST	52..130	CDD:402306	19/77 (25%)
		PDZ_signaling	131..208	CDD:238492	22/92 (24%)
		PDZ_signaling	224..310	CDD:238492	22/124 (18%)
		PDZ_assoc	311..385	CDD:402299	15/79 (19%)
		PDZ_signaling	384..462	CDD:238492	23/80 (29%)
		SH3_DLG3	502..568	CDD:212962	29/67 (43%)
		Guanylate_kin	658..836	CDD:395500	52/182 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810