DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CASK and DLG2

DIOPT Version :9

Sequence 1:	NP_001262811.1	Gene:	CASK / 42567	FlyBaseID:	FBgn0013759	Length:	929	Species:	Drosophila melanogaster
Sequence 2:	XP_016872743.1	Gene:	DLG2 / 1740	HGNCID:	2901	Length:	1039	Species:	Homo sapiens

Alignment Length:	750	Identity:	180/750 - (24%)
Similarity:	296/750 - (39%)	Gaps:	194/750 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   285 QRTHLADTVEELKRYNARRKLKGAVQAIAGGTNMDPLYATDADMPITGATDEWADEEAG-IEAVQ 348
            :|..:.:||.|:|.:...   ||...:||||.....: ..|..:.:|...|..|.::.| ::...
Human   338 RRRPILETVVEIKLFKGP---KGLGFSIAGGVGNQHI-PGDNSIYVTKIIDGGAAQKDGRLQVGD 398

  Fly   349 RILDCLDDIYSLQD-AHVDADVLRDMLRDNRLHQFLQLFDRIAATVVTSNGRAPAAEAVGRCRDV 412
            |:|  :.:.|||:: .|.:|..:   |::.....:|::..  ..|:..::...|.        |:
Human   399 RLL--MVNNYSLEEVTHEEAVAI---LKNTSEVVYLKVGK--PTTIYMTDPYGPP--------DI 448

  Fly   413 LEQLSSTSGGNSLGGKYAKEELMRLL--AAPHMQALLHSHDVVARDVYGEEALRVTPPPMVPYLN 475
            ....|.....:.|.|.....|....|  .:|...:.:..|.:|..|        .|.||...|..
Human   449 THSYSPPMENHLLSGNNGTLEYKTSLPPISPGRYSPIPKHMLVDDD--------YTRPPEPVYST 505

  Fly   476 GDEL----------------------------------DNVEGGELQHVTRVR-----LVQFQKN 501
            .::|                                  |:......||.|..|     |.:....
Human   506 VNKLCDKPASPRHYSPVECDKSFLLSAPYSHYHLGLLPDSEMTSHSQHSTATRQPSMTLQRAVSL 570

  Fly   502 TDEP-----------MGITLKMTEDGRCI-VARIMHGGMIHRQATLHVGDEIREINGQPVQHQSV 554
            ..||           :|..:...|||..| |:.|:.||.......|..||:|..:||..::..|.
Human   571 EGEPRKVVLHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASH 635

  Fly   555 GQLQRMLREARGSVTFKIVPSY------------------------------------RSAPPPC 583
            .|....|:.|..:||  |:..|                                    ||
Human   636 EQAAAALKGAGQTVT--IIAQYQPEDYARFEAKIHDLREQMMNHSMSSGSGSLRTNQKRS----- 693

  Fly   584 EIFVRAQFDYNPLDDELIPCAQAGISFQVGDILQIISKDDHHWWQARLDTVGGSA---GLIPSP- 644
             ::|||.|||:...|..:|  ..|:||:.||||.:|:..|..|||||...:.|.:   |:|||.
Human   694 -LYVRAMFDYDKSKDSGLP--SQGLSFKYGDILHVINASDDEWWQARRVMLEGDSEEMGVIPSKR 755

  Fly   645 --ELQEWRIACQTV----------------DKTKQEQVNCSIFGRKKKQCRDKYLAKHNAIFDTL 691
              |.:| |...:||                ||.|:.    .||.||....::|..::.    :|.
Human   756 RVERKE-RARLKTVKFNAKPGVIDSKGSFNDKRKKS----FIFSRKFPFYKNKEQSEQ----ETS 811

  Fly   692 D----------------------VVTYEEVVKVPVGDPNFQRKTLVLLGAHGVGRRHIKNTLISK 734
            |                      :::||.|.:..:   |:.|..::|    |..:..|.:.|||:
Human   812 DPEQHVSSNASDSESSYRGQEDLILSYEPVTRQEI---NYTRPVIIL----GPMKDRINDDLISE 869

  Fly   735 YPDKYAYPIPHTTRPAKPEEENGRSYYFV-SHDEMMADIGANEYLEYGTHEDAMYGTKLDTIRRI 798
            :|||:...:||||||.:..|.:||.|:|| |.::|..||..::::|.|.:.|.:|||.:.::|.:
Human   870 FPDKFGSCVPHTTRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYGTSVQSVRFV 934

  Fly   799 HTEGKMAILDVEPQALKILRTAEFTPYVVFIAAPSLQNIADYDGSL-ERLAKESE----MLRQLY 858
            ...||..||||...|:|.|:.|:..|..:||...||:.:.:.:..| |..||::.    .|.|.:
Human   935 AERGKHCILDVSGNAIKRLQVAQLYPIAIFIKPRSLEPLMEMNKRLTEEQAKKTYDRAIKLEQEF 999

  Fly   859 GHFFDLTIVNNDISETIATLETAIDRVHTTPQWVP 893
            |.:|...:..:.:.:.....:..|:.......|:|
Human  1000 GEYFTAIVQGDTLEDIYNQCKLVIEEQSGPFIWIP 1034

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CASK	NP_001262811.1	STKc_CASK	8..308	CDD:270996	6/22 (27%)
		S_TKc	12..278	CDD:214567
		L27	347..396	CDD:280918	10/49 (20%)
		L27	406..462	CDD:280918	10/57 (18%)
		PDZ_signaling	493..573	CDD:238492	25/96 (26%)
		SH3_CASK	586..646	CDD:213014	27/65 (42%)
		Guanylate_kin	710..883	CDD:279019	56/178 (31%)
		GuKc	720..883	CDD:214504	54/168 (32%)
DLG2	XP_016872743.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810