DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CASK and Dlg1

DIOPT Version :9

Sequence 1:NP_001262811.1 Gene:CASK / 42567 FlyBaseID:FBgn0013759 Length:929 Species:Drosophila melanogaster
Sequence 2:XP_006521824.1 Gene:Dlg1 / 13383 MGIID:107231 Length:939 Species:Mus musculus


Alignment Length:953 Identity:229/953 - (24%)
Similarity:352/953 - (36%) Gaps:285/953 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   144 PACALLATVDNS---APVKLGGFGSAIQLPGTRETIET---------------HGRVGCPHYMAP 190
            |.|     ||:|   .||:.........||.|..|.||               ...|..|.:::|
Mouse    64 PKC-----VDHSKQCEPVQPVTTWEIASLPSTAVTSETLPGSLSPPVEKYRYQDEEVLPPEHISP 123

  Fly   191 EVVTRRLYGKGCDVWGAGVMLHVLLSGRLPFLGSGVRLQQSVARGRLS----FEA--------PE 243
            : ||..:.|.        .::||....    |.....:...|:...:|    .||        |.
Mouse   124 Q-VTNEVLGP--------ELVHVSEKN----LSEIENVHGFVSHSHISPIKPTEAVPPSSPIVPV 175

  Fly   244 WKSISANAKDLVMKMLA--ANPHHRLSITEVLDHPWIRDRDKLQRTHL--ADTVEELKRYNARRK 304
            ..::...|:..|:...|  |||...|..|:.|:.|          |::  .|...|.:.....|.
Mouse   176 TPALPVPAESTVVLPSAPQANPPPVLVNTDSLETP----------TYVNGTDADYEYEEITLERG 230

  Fly   305 LKGAVQAIAGGTNMDPLYATDADMPIT-----GATDEWADEEAGIEAVQRILDCLDDIYSLQDAH 364
            ..|...:|||||: :|....|:.:.||     ||        |..:...|:.||:..:.      
Mouse   231 NSGLGFSIAGGTD-NPHIGDDSSIFITKIITGGA--------AAQDGRLRVNDCILRVN------ 280

  Fly   365 VDADVLRDMLRDNRLHQFLQLFDRIAATVVT--SNGRAPAAEAVGRCRDVLEQLS---STSGG-- 422
             :||| ||:.....:....:     |.::|.  ...|.||:|.:...:.:.....   |.:||  
Mouse   281 -EADV-RDVTHSKAVEALKE-----AGSIVRLYVKRRKPASEKIMEIKLIKGPKGLGFSIAGGVG 338

  Fly   423 -------NSL-------GGKYAKEELMRLLAAPHMQALLHSHDVVARDVYGEEA----------- 462
                   ||:       ||...|:..:::     ...||..:.|...:|..|||           
Mouse   339 NQHIPGDNSIYVTKIIEGGAAHKDGKLQI-----GDKLLAVNSVCLEEVTHEEAVTALKNTSDFV 398

  Fly   463 -LRVTPPPMVPYLN------------GDELDNVEGGELQHV-----------TRVRLVQFQKN-- 501
             |:|..|..: |:|            ...:||       ||           :..|.....|.  
Mouse   399 YLKVAKPTSM-YINDGYAPPDITNSSSQSVDN-------HVSPSSCLGQTPTSPARYSPISKAVL 455

  Fly   502 -----TDEP-----------MGITLKMTEDGRCI-VARIMHGGMIHRQATLHVGDEIREINGQPV 549
                 |.||           :|..:...|||..| ::.|:.||.......|..||.|..:|...:
Mouse   456 GDDEITREPRKVVLHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDRIISVNSVDL 520

  Fly   550 QHQSVGQLQRMLREARGSVTFKIVPSYRSAPPPCE------------------------------ 584
            :..|..|....|:.|..:||  ||..||    |.|                              
Mouse   521 RAASHEQAAAALKNAGQAVT--IVAQYR----PEEYSRFEAKIHDLREQMMNSSVSSGSGSLRTS 579

  Fly   585 ----IFVRAQFDYNPLDDELIPCAQAGISFQVGDILQIISKDDHHWWQARLDTVGGSA---GLIP 642
                ::|||.|||:...|..:|  ..|::|:.||||.:|:..|..|||||..|..|.:   |:||
Mouse   580 QKRSLYVRALFDYDKTKDSGLP--SQGLNFRFGDILHVINASDDEWWQARQVTPDGESDEVGVIP 642

  Fly   643 SPELQEWRIACQTVDKTKQEQVNCSIFGRKKKQCRDK------------YLAKHNAIFDTLD--- 692
            |..    |:..:...:.|..:.|....|.|.:...||            |..|..:..:|.|   
Mouse   643 SKR----RVEKKERARLKTVKFNSKTRGDKGQSFNDKRKKNLFSRKFPFYKNKDQSEQETSDADQ 703

  Fly   693 -------------------------------VVTYEEVVKVPVGDPNFQRKTLVLLGAHGVGRRH 726
                                           |::||.|.:..|   |:.|..::|    |..:..
Mouse   704 HVTSNASDSESSYLILITDEYGCSKGGQEEYVLSYEPVNQQEV---NYTRPVIIL----GPMKDR 761

  Fly   727 IKNTLISKYPDKYAYPIPHTTRPAKPEEENGRSYYFV-SHDEMMADIGANEYLEYGTHEDAMYGT 790
            :.:.|||::|||:...:||||||.:..|.:||.|:|| |.::|..||..::::|.|.:.:.:|||
Mouse   762 VNDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVTSREQMEKDIQEHKFIEAGQYNNHLYGT 826

  Fly   791 KLDTIRRIHTEGKMAILDVEPQALKILRTAEFTPYVVFIAAPSLQNIADYDGSL--ERLAKESEM 853
            .:.::|.:..:||..||||...|:|.|:.|:..|..:||...|::||.:.:..|  |:..|..|.
Mouse   827 SVQSVRAVAEKGKHCILDVSGNAIKRLQIAQLYPISIFIKPKSMENIMEMNKRLTEEQARKTFER 891

  Fly   854 LRQLYGHFFD--LTIVNNDISETIATLETAIDRVHTTPQ-WVP 893
            ..:|...|.:  ..||..|..|.|......|....:.|. |||
Mouse   892 AMKLEQEFTEHFTAIVQGDTLEDIYNQVKQIIEEQSGPYIWVP 934

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CASKNP_001262811.1 STKc_CASK 8..308 CDD:270996 41/197 (21%)
S_TKc 12..278 CDD:214567 37/165 (22%)
L27 347..396 CDD:280918 10/50 (20%)
L27 406..462 CDD:280918 13/74 (18%)
PDZ_signaling 493..573 CDD:238492 24/98 (24%)
SH3_CASK 586..646 CDD:213014 27/62 (44%)
Guanylate_kin 710..883 CDD:279019 58/177 (33%)
GuKc 720..883 CDD:214504 56/167 (34%)
Dlg1XP_006521824.1 L27_1 2..62 CDD:370268
MAGUK_N_PEST 106..223 CDD:371162 27/139 (19%)
PDZ_signaling 224..308 CDD:238492 24/105 (23%)
PDZ_signaling 317..403 CDD:238492 16/90 (18%)
PDZ_assoc 404..465 CDD:371157 11/68 (16%)
PDZ 463..547 CDD:214570 25/89 (28%)
SH3_DLG1 582..648 CDD:212964 28/71 (39%)
Guanylate_kin 748..926 CDD:366206 59/181 (33%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0194
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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