DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CASK and Card10

DIOPT Version :9

Sequence 1:	NP_001262811.1	Gene:	CASK / 42567	FlyBaseID:	FBgn0013759	Length:	929	Species:	Drosophila melanogaster
Sequence 2:	XP_036014949.1	Gene:	Card10 / 105844	MGIID:	2146012	Length:	1144	Species:	Mus musculus

Alignment Length:	449	Identity:	102/449 - (22%)
Similarity:	152/449 - (33%)	Gaps:	138/449 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   197 LYGKGCDVWGAGVMLHVLLSGRLP-------------FLGSGVRLQQSVARGRLSFEAP-----E 243
            |..:||.:......|.:.:||..|             ..|.|.|...:|.|..||  .|     |
Mouse   698 LLARGCGLDFLNRSLAIRVSGWSPPAGLDPQDKSPDSMPGLGDRWSGAVVRRVLS--GPGSARTE 760

  Fly   244 WKSISANAKDLVMKMLAANPHHRLSITEVLDHPWIRDRDKLQRTHLADTVEELKRYNARRKLKGA 308
            .|...|....|....|.|....|..       ||          :.:.|:..|....|......|
Mouse   761 QKEPRAEGTGLEGAGLEAEAQQRTL-------PW----------NQSSTLPFLLDSKACHSFHEA 808

  Fly   309 VQAIAGGTNMDPLY-ATDADMPITGATDEWADEEAGIEAVQRILDCLDDIYSLQD----AHVDAD 368
            :.|.|.|...:|.| ..:..:|      |.:|..|.....|.||..:|..:..:.    ..||..
Mouse   809 LDAWAKGPGAEPFYIRANFSLP------ERSDPHALCVKAQEILRLVDPAHKRRQEWFCTRVDTL 867

  Fly   369 VLRDMLRD-----NRLHQFLQLFDRIAATVVTSNGRAPAA----EAVGRCRDVLEQLSSTSGGNS 424
            .|||:.|.     .|..|.|::.::.   :::|..|:|.:    .|:|..|      ...:||.:
Mouse   868 TLRDLDRGTVPNYQRAQQLLEVQEKY---LISSRHRSPRSNLKKRALGLVR------PKPAGGTA 923

  Fly   425 LGGKYAKE-------ELMRLLAAPH--MQALLHSHDVVARDVYGEEALR---VTPPPMVPYLNGD 477
              |..|::       ||.|.| .|:  ::.||.|            |||   :.|..:.|.|..:
Mouse   924 --GDSAEQLPAEPCSELERSL-KPYSLVRPLLVS------------ALRPVVLLPECLAPRLIRN 973

  Fly   478 ELD-------------NVEGGELQHV-----------------TRVRLVQFQKNTDEPMGITLKM 512
            .||             ....||.|..                 :|:|.:|      |.:|....:
Mouse   974 LLDLPSSRLDFQVCPAESLSGEEQCTSSAPGAPKAWPATAGLGSRIRAIQ------ESVGKKHCL 1032

  Fly   513 TEDGRCIVARIMHGG----MIHRQATLHVGDEIREINGQPVQHQSVGQLQRMLREARGS 567
            .|.|...|..::|..    :||.:.|.....|||.:.|:|....|     .:||:.|||
Mouse  1033 LELGARGVRELVHSEVYPIVIHVEVTEKNVREIRGLLGRPGWRDS-----ELLRQCRGS 1086

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CASK	NP_001262811.1	STKc_CASK	8..308	CDD:270996	27/128 (21%)
		S_TKc	12..278	CDD:214567	23/98 (23%)
		L27	347..396	CDD:280918	13/57 (23%)
		L27	406..462	CDD:280918	14/64 (22%)
		PDZ_signaling	493..573	CDD:238492	22/79 (28%)
		SH3_CASK	586..646	CDD:213014
		Guanylate_kin	710..883	CDD:279019
		GuKc	720..883	CDD:214504
Card10	XP_036014949.1	CARD_CARD10_CARMA3	150..235	CDD:260069
		Smc	<270..>573	CDD:224117
		SH3	822..884	CDD:418401	16/67 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900