DRSC/TRiP Functional Genomics Resources

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Protein Alignment CASK and PATJ

DIOPT Version :9

Sequence 1:NP_001262811.1 Gene:CASK / 42567 FlyBaseID:FBgn0013759 Length:929 Species:Drosophila melanogaster
Sequence 2:XP_011538764.1 Gene:PATJ / 10207 HGNCID:28881 Length:1937 Species:Homo sapiens


Alignment Length:647 Identity:125/647 - (19%)
Similarity:207/647 - (31%) Gaps:233/647 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly   142 VRPA-CALLATVDNSAPVKLGGFGSAIQLPGTRETIETHGRVGCP-------------HYMAPEV 192
            |.|| |.::...:....:..|..|..:.:.|.::| ....|:|.|             |:...||
Human  1448 VDPATCPIVPGQEMIIEISKGRSGLGLSIVGGKDT-PLFWRLGSPRAWSQHLVRAFMLHHPVTEV 1511

  Fly   193 ------VTRRLYGKGC-----DVWGAGVMLHVLLSGRLPFLGSGVRLQQSVARGRLSFEAPEWKS 246
                  |...:|.:|.     .:|....:|.|          :||.|:.|      |.|    ::
Human  1512 EGQNAIVIHEVYEEGAAARDGRLWAGDQILEV----------NGVDLRNS------SHE----EA 1556

  Fly   247 ISANAKDLVMKMLAANPHHRLSITEVLDHPWIRDRDKLQRTHLADTVEELKRYNARRKL-KGAVQ 310
            |:|         |...| .::.:....|....||.:.|          |:...:.::|. :|...
Human  1557 ITA---------LRQTP-QKVRLVVYRDEAHYRDEENL----------EIFPVDLQKKAGRGLGL 1601

  Fly   311 AIAGGTNMDPLYATD------ADM--------PITGATDEWAD-EEAGIEAVQRILDCLDDIYSL 360
            :|.|..|...::.:|      ||:        .|.....|  | ..|..|.|..||.|...:..|
Human  1602 SIVGKRNGSGVFISDIVKGGAADLDGRLIQGDQILSVNGE--DMRNASQETVATILKCAQGLVQL 1664

  Fly   361 QDAHVDADVLRDMLRDNRLHQFLQLFDRIAATVVTSNGRAPAAEAVGRCRDVLEQLSSTSGGNSL 425
            :                                            :||.|......:.|:..||.
Human  1665 E--------------------------------------------IGRLRAGSWTSARTTSQNSQ 1685

  Fly   426 GGKYAKEELMRLLAAPHMQALLHSHDVVARDVYGEEALRVTPPPMVPYLNGDELDNVEGGELQHV 490
            |.:.:.........||.:..|        :::.|.:  ||:.|....  :|.:::          
Human  1686 GSQQSAHSSCHPSFAPVITGL--------QNLVGTK--RVSDPSQKN--SGTDME---------- 1728

  Fly   491 TRVRLVQFQKNTDEPMGITLKMTEDGR--------CIVARIMHGGMIHRQATLHVGDEIREINGQ 547
              .|.|:..:...:.:||::   ..||        ..:|.|...|:..|...|.|||.|..||||
Human  1729 --PRTVEINRELSDALGISI---AGGRGSPLGDIPVFIAMIQASGVAARTQKLKVGDRIVSINGQ 1788

  Fly   548 PVQHQSVGQLQRMLREARGSVTFKIV----------------PSYRSAPPPCEIFVRAQFDYNPL 596
            |:...|...:..:|:.|.|.:..::|                ..|....|..|        ::|.
Human  1789 PLDGLSHADVVNLLKNAYGRIILQVVADTNISAIAAQLENMSTGYHLGSPTAE--------HHPE 1845

  Fly   597 DDELIP-------CAQAGISFQVGDILQIISKDDHHWWQARLDTVGGSAGLIPSPELQEWRIACQ 654
            |.|..|       ....|:.|.:                     |||...  |..:|..:     
Human  1846 DTETPPPKIITLEKGSEGLGFSI---------------------VGGYGS--PHGDLPIY----- 1882

  Fly   655 TVDKTKQEQVNCSIFGRKKKQCRDKYLAKHNAIFDTLDVVTYEEVVKVPVGDPNFQRKTLVL 716
              .||...:...:..||.|:  .|:.||.:.   :||:.||:|:.|.:    ...||.|:.|
Human  1883 --VKTVFAKGAAADDGRLKR--GDQILAVNG---ETLEGVTHEQAVAI----LKHQRGTVTL 1933

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CASKNP_001262811.1 STKc_CASK 8..308 CDD:270996 36/191 (19%)
S_TKc 12..278 CDD:214567 31/160 (19%)
L27 347..396 CDD:280918 5/48 (10%)
L27 406..462 CDD:280918 11/55 (20%)
PDZ_signaling 493..573 CDD:238492 24/87 (28%)
SH3_CASK 586..646 CDD:213014 10/66 (15%)
Guanylate_kin 710..883 CDD:279019 4/7 (57%)
GuKc 720..883 CDD:214504
PATJXP_011538764.1 L27_2 8..65 CDD:117611
PDZ_signaling 135..218 CDD:238492
PDZ_signaling 246..325 CDD:238492
PDZ_signaling 366..450 CDD:238492
PDZ_signaling 570..634 CDD:238492
PDZ 683..772 CDD:214570
PDZ_signaling 1066..1157 CDD:238492
PDZ 1236..1321 CDD:214570
PDZ 1459..1574 CDD:214570 26/145 (18%)
PDZ_signaling 1586..1666 CDD:238492 18/125 (14%)
PDZ_signaling 1729..1814 CDD:238492 24/87 (28%)
PDZ_signaling 1852..1936 CDD:238492 25/121 (21%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0194
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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