DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CASK and mpp7b

DIOPT Version :9

Sequence 1:	NP_001262811.1	Gene:	CASK / 42567	FlyBaseID:	FBgn0013759	Length:	929	Species:	Drosophila melanogaster
Sequence 2:	XP_021324128.1	Gene:	mpp7b / 101882129	ZFINID:	ZDB-GENE-141212-293	Length:	298	Species:	Danio rerio

Alignment Length:	256	Identity:	102/256 - (39%)
Similarity:	145/256 - (56%)	Gaps:	37/256 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   416 LSSTSGGNSLGGKYAKE-----------ELMRLLAAPHMQALLHSHDVVARDVYGEEALRVTPPP 469
            |.||.|   |..:.|:|           ||:.||:.||:|.||..|||||:..:..   |:.|.|
Zfish    26 LDSTQG---LAHRLAEELQDTVNSPETTELLNLLSKPHVQTLLLVHDVVAQKRFDP---RLPPLP 84

  Fly   470 MVPYLNGDELDNVEGGELQHVTRVRLVQFQKNTDEPMGITLKMTE-DGRCIVARIMHGGMIHRQA 533
            .:|..|.::.|:           :::|...|| .||:|.|:|..| .|..||||:|.||...|..
Zfish    85 PLPDCNEEDEDS-----------IKIVCLVKN-QEPLGATIKRDESSGAIIVARVMRGGAADRSG 137

  Fly   534 TLHVGDEIREINGQPVQHQSVGQLQRMLREARGSVTFKIVPSYRS--APPPCEIFVRAQFDYNPL 596
            .:|.||.::|:||.||:.:::.::..:|.::.|:||||:||....  .....::||||.|||:|.
Zfish   138 LIHEGDMLKEVNGVPVEDKNLQEIIPILAKSEGAVTFKVVPGTNEELETNDTQVFVRALFDYDPQ 202

  Fly   597 DDELIPCAQAGISFQVGDILQIISKDDHHWWQARLDTVGGS---AGLIPSPELQEWRIACQ 654
            .|..|||..||:.||.||:|||:|:||..|||||..  |.:   ||||||.:|||.|:..|
Zfish   203 ADPAIPCRDAGLEFQRGDVLQIVSQDDDTWWQARRH--GDANLRAGLIPSRQLQERRVMLQ 261

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CASK	NP_001262811.1	STKc_CASK	8..308	CDD:270996
		S_TKc	12..278	CDD:214567
		L27	347..396	CDD:280918
		L27	406..462	CDD:280918	21/56 (38%)
		PDZ_signaling	493..573	CDD:238492	32/80 (40%)
		SH3_CASK	586..646	CDD:213014	36/62 (58%)
		Guanylate_kin	710..883	CDD:279019
		GuKc	720..883	CDD:214504
mpp7b	XP_021324128.1	L27	31..74	CDD:308467	18/45 (40%)
		PDZ	97..179	CDD:214570	33/82 (40%)
		SH3_MPP	192..252	CDD:212796	36/61 (59%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910