DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CASK and card14

DIOPT Version :9

Sequence 1:	NP_001262811.1	Gene:	CASK / 42567	FlyBaseID:	FBgn0013759	Length:	929	Species:	Drosophila melanogaster
Sequence 2:	XP_002937355.2	Gene:	card14 / 100486738	XenbaseID:	XB-GENE-989887	Length:	972	Species:	Xenopus tropicalis

Alignment Length:	699	Identity:	129/699 - (18%)
Similarity:	234/699 - (33%)	Gaps:	223/699 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 LKHPHIVELLETYSSEGMLYMVFEFMEGSDLCFEVVRRAVAGFVYSEAVACHYMRQILEALRYCH 133
            :::.|.::..:|..|:..     |..|......|.:.|.......|::...|  .|..|.|....
Frog   203 MRYSHALQEKDTVQSKNS-----ELQEQFYAMREELNRLRMDLQVSKSWTTH--AQCEEELLCLR 260

  Fly   134 ENDILHRDVRPACALLATVDNSAPVKLGGFGSAIQLPGTRETIETHGRVGCPHYMAPEVVTRRLY 198
            |.:...|| ||....|.|::...|:.       :.|.|.:|.: ...|:......|.|.| .:|:
Frog   261 EENRQLRD-RPTQEELGTLEEQQPLD-------VTLQGNQELL-AQLRLSKEKLAASEAV-EKLW 315

  Fly   199 GKGCDVWGAGVMLHVLLSGRLPFLGSGVRLQQSVARGRLS------FEAPEWKSISANAKDLVM- 256
            .|..|         .::..|     ..::|:..:.|.:..      .|..:.:..:..|:|:|.
Frog   316 EKEKD---------TMVQER-----HNLQLECDILRKKSEAFHSHVCELKKERDQAYRARDMVQT 366

  Fly   257 ---KMLAANPHHRLSITEVLDHPWIRDRDKLQRTHLADTVEELKRYNARRKLKGAVQAI------ 312
               .:||.....|..:.|:.|    |:.:.||:  :....|:|:   .:|:::|::.|.
Frog   367 EISTILAEKDSLRQQVMELTD----RNSELLQQ--ILSLQEQLQ---TQREMRGSLHACEQRDVS 422

  Fly   313 --AGGTNMDPLYAT----DADMPITGATDE-WADEEAGIEAVQRILDCLDDIYSLQDAHVD---- 366
              :....:..:||.    :....::.:..| |.:     .:.|...|..:...|....|.|
Frog   423 TKSKHMRLVRMYAVCPSEEGSRSLSSSISETWTE-----NSCQTSSDLGESFNSYAPPHDDYLTD 482

  Fly   367 -----ADVLRDMLR------DNRLHQFLQLFDRIAATVVTSNGRAPAAEAVGR---CR------- 410
                 :..|.|:|:      |:...:.|.:|.::.::...|:....|.....|   ||
Frog   483 LTKSASQDLPDLLQTEKTETDSEYEEGLPMFSQMQSSESCSSYNNLAISVPRRRHACRDTSRVTV 547

  Fly   411 ------DVLEQLSSTSGGNSLGGKYAKEELMRLLAAPHMQALLHSHDVVARDVYGEEALRVTPPP 469
                  |:|:|: |..|||..|                    :..|.|.......|.:||
Frog   548 IAFQGDDLLKQI-SIIGGNRTG--------------------IFIHRVTEGSAADEMSLR----- 586

  Fly   470 MVPYLNGDELDNVEGGELQHVTRVRLVQFQKNTDEPMGITLKMTEDGRCIVARIMHGGMIHRQAT 534
                 .|.::..|:...|....:|.|          .|:|   :||..||:.|:  .|.    ..
Frog   587 -----PGYQIIAVDFDVLNPSYKVAL----------EGMT---SEDAHCILNRV--NGF----CC 627

  Fly   535 LHV---GDEIREINGQPVQHQSVGQLQRMLREAR-GSVTFKIVPSYRSAPPPCEIFVRAQFDYNP 595
            |.|   .||.|                ::||:.. |||:                  .....|..
Frog   628 LSVKCNKDEYR----------------KLLRDIESGSVS------------------SGDSFYVQ 658

  Fly   596 LDDELIPCAQAGISFQVGDILQI---ISKDDHHWWQARLDTV---GGSAGLIPS-PELQE----- 648
            ::..:......|:....|:||.|   :.|..:.|:..|::..   .|.:|:||: |:.|:
Frog   659 VNQSMAGRVGGGLQVTCGEILHITDTMYKGSYQWFAHRVNAYTMKDGESGIIPNYPQAQQQLITT 723

  Fly   649 -----W----------RIACQTVDKTKQE----QVNCSIFGRKKKQCRD 678
                 |          :|...:.|:....    .::|.|.     ||.|
Frog   724 IQHLTWQNGTPRRPQKQIRIVSTDRCNSHLLWTSLDCGIC-----QCED 767

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CASK	NP_001262811.1	STKc_CASK	8..308	CDD:270996	48/248 (19%)
		S_TKc	12..278	CDD:214567	42/218 (19%)
		L27	347..396	CDD:280918	11/63 (17%)
		L27	406..462	CDD:280918	14/71 (20%)
		PDZ_signaling	493..573	CDD:238492	20/83 (24%)
		SH3_CASK	586..646	CDD:213014	14/66 (21%)
		Guanylate_kin	710..883	CDD:279019
		GuKc	720..883	CDD:214504
card14	XP_002937355.2	DD	26..104	CDD:387368
		Smc	<146..>413	CDD:224117	49/249 (20%)
		PDZ_signaling	559..631	CDD:238492	24/121 (20%)
		SH3	653..717	CDD:388381	14/63 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910