DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CASK and pals1b

DIOPT Version :9

Sequence 1:	NP_001262811.1	Gene:	CASK / 42567	FlyBaseID:	FBgn0013759	Length:	929	Species:	Drosophila melanogaster
Sequence 2:	NP_001171218.2	Gene:	pals1b / 100422734	ZFINID:	ZDB-GENE-060531-2	Length:	639	Species:	Danio rerio

Alignment Length:	612	Identity:	181/612 - (29%)
Similarity:	305/612 - (49%)	Gaps:	89/612 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   328 MPITGATDEWADEEAGIEAVQRILDCLDDIYSL---QDAHVDADVLRDMLRDNRLHQ-FLQLFDR 388
            |.||    |.:.||.....:..:|.||..::..   :::..|.::|.|:|......| |:
Zfish    72 MNIT----EASSEEKSTTDLDSVLQCLHHLHQCVLDEESQQDVELLLDLLLQTNFQQAFI----- 127

  Fly   389 IAATVVTSNGR---------APAAEAVGRCRDVLEQLSSTSGGNSLGGKYAKEELMRLLAAPHMQ 444
            :..:|.....|         |.|.:..|:...||:....|..          .||..||.:||:|
Zfish   128 MQRSVAQGMSRLCPPPYPLTAHAQQLRGQVESVLQSSKHTEA----------TELTGLLTSPHLQ 182

  Fly   445 ALLHSHDVVARDVYGEEALRVTPPPMVPYLNGDELDNVEGGELQHVTRVRLVQFQKNTDEPMGIT 509
            ||:.:||.:|     |:.|              ::|.:|..:....| .:||..:|..|.|:|:|
Zfish   183 ALMEAHDCIA-----EQEL--------------DVDTIEAVDQDEKT-TKLVSLEKIRDIPLGVT 227

  Fly   510 LKMTEDGRCIV-ARIMHGGMIHRQATLHVGDEIREINGQPVQHQSVGQLQRMLREARGSVTFKIV 573
            ::..:|  |:| :|::.||...:...|..||||.|||..||:.::|..:..:|....||:||.::
Zfish   228 VRNEQD--CVVISRVVSGGTAEKSNLLSEGDEILEINNIPVRGKTVNDVHDLLSSMYGSLTFLLI 290

  Fly   574 PSYRSAPP---PCEIFVRAQFDYNPLDDELIPCAQAGISFQVGDILQIISKDDHHWWQARL---D 632
            |:..:..|   |..:.|:|.|.|:|.:|..:||.:.|:|||.||||.:.|:||.:||||..   |
Zfish   291 PNSHNKLPLDRPTVMHVKANFSYDPSEDPYVPCKELGLSFQRGDILHVTSQDDPNWWQAYREGHD 355

  Fly   633 TVGGSAGLIPSPELQEWRIACQTVDKTKQEQVN----CSIFGRKKKQCRDKYLAKHNAIFD--TL 691
            .....|||||....|:.|.|.:.....|.|:..    |:|  |.||. |.|.|...|...:  :.
Zfish   356 DQKPLAGLIPGKNFQQHREAMKKTITDKNEEYKGKLWCAI--RSKKH-RKKLLYNPNKNIEHYSE 417

  Fly   692 DVVTYEEVVKVPVGDPNFQRKTLVLLGAHGVGRRHIKNTLISKYPDKYAYPIPHTTRPAKPEEEN 756
            |::|||||..  ...|..:::.:.|:|....|:..::..|:|..|:::|..:|||||..:..|.|
Zfish   418 DILTYEEVSL--YRQPPDRKRPVALIGPANSGQDELRQRLLSSEPERFAAAVPHTTRSPRVHEVN 480

  Fly   757 GRSYYFVSHDEMMADIGANEYLEYGTHEDAMYGTKLDTIRRIHTEGKMAILDVEPQALKILRTAE 821
            ||.|.|||.....:::.|.:::|.|.:.:.:|||..|::|::...||:.:|.::|::|::|.:::
Zfish   481 GREYNFVSRQSFESELSAGKFIESGEYGNNLYGTNADSVRQVVNSGKICLLCLQPRSLQVLCSSD 545

  Fly   822 FTPYVVFI--AAPSLQNIADYD--------GSLERLAKE----SEMLRQL---YGHFFDLTIVNN 869
            ..||::||  :.|.|......:        |..:|:.::    .|..|::   |||.||..|.||
Zfish   546 LKPYIIFIRPSPPPLSPPPPQERFSTMLARGVKKRMPEDVREMMEKAREMEDSYGHLFDTFITNN 610

  Fly   870 DISETIATLETAIDRVHTTPQWVPVSW 896
            :..:::..|.:.|.::...|||:|.:|
Zfish   611 EPEKSVCELLSIIQKLDNEPQWIPSAW 637

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CASK	NP_001262811.1	STKc_CASK	8..308	CDD:270996
		S_TKc	12..278	CDD:214567
		L27	347..396	CDD:280918	10/52 (19%)
		L27	406..462	CDD:280918	17/55 (31%)
		PDZ_signaling	493..573	CDD:238492	29/80 (36%)
		SH3_CASK	586..646	CDD:213014	29/62 (47%)
		Guanylate_kin	710..883	CDD:279019	53/189 (28%)
		GuKc	720..883	CDD:214504	51/179 (28%)
pals1b	NP_001171218.2	L27_N	86..133	CDD:312557	9/51 (18%)
		L27	156..197	CDD:197794	17/69 (25%)
		PDZ_signaling	211..290	CDD:238492	29/80 (36%)
		SH3_MPP5	306..367	CDD:212969	29/60 (48%)
		Guanylate_kin	434..626	CDD:331880	54/191 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810