Protein Alignment CASK and caskb

DIOPT Version :10

• Sequence 1: NP_001262811.1
• Gene: CASK / 42567
• FlyBaseID: FBgn0013759
• Length: 929
• Species: Drosophila melanogaster
• Sequence 2: XP_073808534.1
• Gene: caskb / 100148073
• ZFINID: ZDB-GENE-030131-4473
• Length: 948
• Species: Danio rerio
• Alignment Length: 970
• Identity: 567/970 - (58%)
• Similarity: 706/970 - (72%)
• Gaps: 94/970 - (9%)

  Fly     1 MTEDEILFDDVYELCEVIGKGPFSIVRRCIHRESNQQFAVKIVDVAKFTASPGLSTADLKREATI 65
            |.:|::||:|||||||||||||||:|||||:|::.|||||||||||.||:||||||.||||||:|
Zfish     1 MADDDVLFEDVYELCEVIGKGPFSVVRRCINRDTGQQFAVKIVDVASFTSSPGLSTEDLKREASI 65

  Fly    66 CHMLKHPHIVELLETYSSEGMLYMVFEFMEGSDLCFEVVRRAVAGFVYSEAVACHYMRQILEALR 130
            ||||||||||||||||||:||||||||||:|:|||||:|:||.||||||||||.|||||||||||
Zfish    66 CHMLKHPHIVELLETYSSDGMLYMVFEFMDGADLCFEIVKRADAGFVYSEAVASHYMRQILEALR 130

  Fly   131 YCHENDILHRDVRPACALLATVDNSAPVKLGGFGSAIQLPGTRETIETHGRVGCPHYMAPEVVTR 195
            |||:|:::||||:|.|.|||:.:|||||||||||.||||  ....:...||||.||:||||||.|
Zfish   131 YCHDNNVIHRDVKPHCVLLASKENSAPVKLGGFGVAIQL--GESGLVAGGRVGTPHFMAPEVVKR 193

  Fly   196 RLYGKGCDVWGAGVMLHVLLSGRLPFLGSGVRLQQSVARGRLSFEAPEWKSISANAKDLVMKMLA 260
            ..|||..||||.||:|.:||||.|||.|:..||.:::.:|:......:|..||.:|||||.:||.
Zfish   194 EPYGKPVDVWGCGVILFILLSGCLPFYGTKERLFEAIIKGKYKMNPRQWAHISESAKDLVRRMLM 258

  Fly   261 ANPHHRLSITEVLDHPWIRDRDKLQ-RTHLADTVEELKRYNARRKLKGAVQAIAGGTNMDPLYAT 324
            .:|..|:::.|.|:|||:::||:.. :.||.:|||:|:::||||||||||.|.......:..|
Zfish   259 LDPAERITVYEALNHPWLKERDRYSYKIHLPETVEQLRKFNARRKLKGAVLAAVSSHKFNSFY-- 321

  Fly   325 DADMPITGATDEWADEE------AGIEAVQRILDCLDDIYSLQD-AHVDADVLRDMLRDNRLHQF 382
             .|.|  ....:::::.      |...||.::||.|::|::|.| :..|.|.|..:.:|..||..
Zfish   322 -GDPP--EDLHDFSEDPTSSGLLAAERAVSQVLDSLEEIHALTDCSEKDLDFLHSVFQDQHLHTL 383

  Fly   383 LQLFDRIAATVVTSNGRAPAAEAVGRCRDVLEQLSSTSGGNSLGGKYAK----EELMRLLAAPHM 443
            |.|:|:| .|..:...|.|.::||.|.::|||.:|.          |.:    :||.|:|..||.
Zfish   384 LDLYDKI-NTRSSPQIRNPPSDAVQRAKEVLETISC----------YPENMEAKELKRILTQPHF 437

  Fly   444 QALLHSHDVVARDVYGEEALRVTPPPMVPYLNGDELDNVEGG-ELQHVTRVRLVQFQKNTDEPMG 507
            .|||.:|||||.:||.::||||||||..||||||..::|.|. :|::||||||||||||||||||
Zfish   438 MALLQTHDVVAHEVYSDDALRVTPPPTSPYLNGDSPESVNGDLDLENVTRVRLVQFQKNTDEPMG 502

  Fly   508 ITLKMTEDGRCIVARIMHGGMIHRQATLHVGDEIREINGQPVQHQSVGQLQRMLREARGSVTFKI 572
            |||||.:...|||||||||||||||.|||||||||||||..|.:|:|.|||:||||.|||:||||
Zfish   503 ITLKMNDLNHCIVARIMHGGMIHRQGTLHVGDEIREINGISVANQTVEQLQKMLREMRGSITFKI 567

  Fly   573 VPSYRSAPPPCE------------------------------------------------IFVRA 589
            ||||||....|:                                                |:|||
Zfish   568 VPSYRSQSLSCDKESPDLSRQSPANGHSSVTSSILDLPSTIQPKGRQISRAAVKDKLGRKIYVRA 632

  Fly   590 QFDYNPLDDELIPCAQAGISFQVGDILQIISKDDHHWWQARLD-TVGGSAGLIPSPELQEWRIAC 653
            ||:|:|..||||||.:|||.|:||||:||||||||:|||.:|: |..|:|||||||||||||:||
Zfish   633 QFEYDPAKDELIPCKEAGIRFRVGDIIQIISKDDHNWWQGKLENTKNGTAGLIPSPELQEWRVAC 697

  Fly   654 QTVDKTKQE-QVNCSIFGRKKKQCRDKYLAKHNAIFDTLDVVTYEEVVKVPVGDPNFQRKTLVLL 717
            ..::||||| |.:|:.||:||||.:|||||||||:||.||:||||||||:|.    |:|||||||
Zfish   698 IAMEKTKQEQQASCTWFGKKKKQYKDKYLAKHNAVFDQLDLVTYEEVVKLPA----FKRKTLVLL 758

  Fly   718 GAHGVGRRHIKNTLISKYPDKYAYPIPHTTRPAKPEEENGRSYYFVSHDEMMADIGANEYLEYGT 782
            |||||||||||||||:|:|||:||||||||||.|.:||||::|:|||||:||.||..|||||||:
Zfish   759 GAHGVGRRHIKNTLIAKHPDKFAYPIPHTTRPPKKDEENGKNYFFVSHDQMMQDISNNEYLEYGS 823

  Fly   783 HEDAMYGTKLDTIRRIHTEGKMAILDVEPQALKILRTAEFTPYVVFIAAPSLQNIADY------- 840
            ||||||||:|:|||:||....:|||||||||||:||||||:|||||||||::......
Zfish   824 HEDAMYGTRLETIRKIHELNMVAILDVEPQALKVLRTAEFSPYVVFIAAPTITPAMTELPRWCRK 888

  Fly   841 --DGSLERLAKESEMLRQLYGHFFDLTIVNNDISETIATLETAIDRVHTTPQWVPVSWLY 898
              |.||:||.||||.|:..|.|:||.||:||:|.:||..||.|::.|.:|.|||||||:|
Zfish   889 LPDESLQRLQKESEALQHSYAHYFDQTIINNEIDDTIRLLEEAVELVCSTAQWVPVSWVY 948

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CASK	NP_001262811.1	STKc_CASK	8..308	CDD:270996	200/300 (67%)
		L27	347..396	CDD:460717	18/49 (37%)
		L27	406..462	CDD:460717	23/59 (39%)
		PDZ_CASK-like	494..574	CDD:467267	64/79 (81%)
		SH3_CASK	586..646	CDD:213014	42/60 (70%)
		Guanylate_kin	710..883	CDD:395500	122/181 (67%)
caskb	XP_073808534.1	None