DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CASK and caskb

DIOPT Version :9

Sequence 1:	NP_001262811.1	Gene:	CASK / 42567	FlyBaseID:	FBgn0013759	Length:	929	Species:	Drosophila melanogaster
Sequence 2:	NP_001135848.1	Gene:	caskb / 100148073	ZFINID:	ZDB-GENE-030131-4473	Length:	921	Species:	Danio rerio

Alignment Length:	948	Identity:	564/948 - (59%)
Similarity:	702/948 - (74%)	Gaps:	77/948 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MTEDEILFDDVYELCEVIGKGPFSIVRRCIHRESNQQFAVKIVDVAKFTASPGLSTADLKREATI 65
            |.:|::||:|||||||||||||||:|||||:|::.|||||||||||.||:||||||.||||||:|
Zfish     1 MADDDVLFEDVYELCEVIGKGPFSVVRRCINRDTGQQFAVKIVDVASFTSSPGLSTEDLKREASI 65

  Fly    66 CHMLKHPHIVELLETYSSEGMLYMVFEFMEGSDLCFEVVRRAVAGFVYSEAVACHYMRQILEALR 130
            ||||||||||||||||||:||||||||||:|:|||||:|:||.||||||||||.|||||||||||
Zfish    66 CHMLKHPHIVELLETYSSDGMLYMVFEFMDGADLCFEIVKRADAGFVYSEAVASHYMRQILEALR 130

  Fly   131 YCHENDILHRDVRPACALLATVDNSAPVKLGGFGSAIQLPGTRETIETHGRVGCPHYMAPEVVTR 195
            |||:|:::||||:|.|.|||:.:|||||||||||.||||  ....:...||||.||:||||||.|
Zfish   131 YCHDNNVIHRDVKPHCVLLASKENSAPVKLGGFGVAIQL--GESGLVAGGRVGTPHFMAPEVVKR 193

  Fly   196 RLYGKGCDVWGAGVMLHVLLSGRLPFLGSGVRLQQSVARGRLSFEAPEWKSISANAKDLVMKMLA 260
            ..|||..||||.||:|.:||||.|||.|:..||.:::.:|:......:|..||.:|||||.:||.
Zfish   194 EPYGKPVDVWGCGVILFILLSGCLPFYGTKERLFEAIIKGKYKMNPRQWAHISESAKDLVRRMLM 258

  Fly   261 ANPHHRLSITEVLDHPWIRDRDKLQ-RTHLADTVEELKRYNARRKLKGAVQAIAGGTNMDPLYAT 324
            .:|..|:::.|.|:|||:::||:.. :.||.:|||:|:::||||||||||.|.......:..|
Zfish   259 LDPAERITVYEALNHPWLKERDRYSYKIHLPETVEQLRKFNARRKLKGAVLAAVSSHKFNSFY-- 321

  Fly   325 DADMPITGATDEWADEE------AGIEAVQRILDCLDDIYSLQD-AHVDADVLRDMLRDNRLHQF 382
             .|.|  ....:::::.      |...||.::||.|::|::|.| :..|.|.|..:.:|..||..
Zfish   322 -GDPP--EDLHDFSEDPTSSGLLAAERAVSQVLDSLEEIHALTDCSEKDLDFLHSVFQDQHLHTL 383

  Fly   383 LQLFDRIAATVVTSNGRAPAAEAVGRCRDVLEQLSSTSGGNSLGGKYAK----EELMRLLAAPHM 443
            |.|:|:| .|..:...|.|.::||.|.::|||.:|.          |.:    :||.|:|..||.
Zfish   384 LDLYDKI-NTRSSPQIRNPPSDAVQRAKEVLETISC----------YPENMEAKELKRILTQPHF 437

  Fly   444 QALLHSHDVVARDVYGEEALRVTPPPMVPYLNGDELDNVEGG-ELQHVTRVRLVQFQKNTDEPMG 507
            .|||.:|||||.:||.::||||||||..||||||..::|.|. :|::||||||||||||||||||
Zfish   438 MALLQTHDVVAHEVYSDDALRVTPPPTSPYLNGDSPESVNGDLDLENVTRVRLVQFQKNTDEPMG 502

  Fly   508 ITLKMTEDGRCIVARIMHGGMIHRQATLHVGDEIREINGQPVQHQSVGQLQRMLREARGSVTFKI 572
            |||||.:...|||||||||||||||.|||||||||||||..|.:|:|.|||:||||.|||:||||
Zfish   503 ITLKMNDLNHCIVARIMHGGMIHRQGTLHVGDEIREINGISVANQTVEQLQKMLREMRGSITFKI 567

  Fly   573 VPSYRSAPPPC-----------------------------------EIFVRAQFDYNPLDDELIP 602
            ||||||....|                                   :|:|||||:|:|..|||||
Zfish   568 VPSYRSQSLSCDKESPDLSRQSPANGHSSVTSSILDLPSTIQPKGRQIYVRAQFEYDPAKDELIP 632

  Fly   603 CAQAGISFQVGDILQIISKDDHHWWQARLD-TVGGSAGLIPSPELQEWRIACQTVDKTKQE-QVN 665
            |.:|||.|:||||:||||||||:|||.:|: |..|:|||||||||||||:||..::||||| |.:
Zfish   633 CKEAGIRFRVGDIIQIISKDDHNWWQGKLENTKNGTAGLIPSPELQEWRVACIAMEKTKQEQQAS 697

  Fly   666 CSIFGRKKKQCRDKYLAKHNAIFDTLDVVTYEEVVKVPVGDPNFQRKTLVLLGAHGVGRRHIKNT 730
            |:.||:||||.:|||||||||     |:||||||||:|.    |:||||||||||||||||||||
Zfish   698 CTWFGKKKKQYKDKYLAKHNA-----DLVTYEEVVKLPA----FKRKTLVLLGAHGVGRRHIKNT 753

  Fly   731 LISKYPDKYAYPIPHTTRPAKPEEENGRSYYFVSHDEMMADIGANEYLEYGTHEDAMYGTKLDTI 795
            ||:|:|||:||||||||||.|.:||||::|:|||||:||.||..|||||||:||||||||:|:||
Zfish   754 LIAKHPDKFAYPIPHTTRPPKKDEENGKNYFFVSHDQMMQDISNNEYLEYGSHEDAMYGTRLETI 818

  Fly   796 RRIHTEGKMAILDVEPQALKILRTAEFTPYVVFIAAPSLQNIADYDGSLERLAKESEMLRQLYGH 860
            |:||....:|||||||||||:||||||:|||||||||::......|.||:||.||||.|:..|.|
Zfish   819 RKIHELNMVAILDVEPQALKVLRTAEFSPYVVFIAAPTITPAMTEDESLQRLQKESEALQHSYAH 883

  Fly   861 FFDLTIVNNDISETIATLETAIDRVHTTPQWVPVSWLY 898
            :||.||:||:|.:||..||.|::.|.:|.|||||||:|
Zfish   884 YFDQTIINNEIDDTIRLLEEAVELVCSTAQWVPVSWVY 921

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CASK	NP_001262811.1	STKc_CASK	8..308	CDD:270996	200/300 (67%)
		S_TKc	12..278	CDD:214567	181/265 (68%)
		L27	347..396	CDD:280918	18/49 (37%)
		L27	406..462	CDD:280918	23/59 (39%)
		PDZ_signaling	493..573	CDD:238492	64/79 (81%)
		SH3_CASK	586..646	CDD:213014	42/60 (70%)
		Guanylate_kin	710..883	CDD:279019	122/172 (71%)
		GuKc	720..883	CDD:214504	113/162 (70%)
caskb	NP_001135848.1	STKc_CASK	8..307	CDD:270996	200/300 (67%)
		S_TKc	12..276	CDD:214567	181/265 (68%)
		L27	348..>390	CDD:197794	15/41 (37%)
		L27	406..452	CDD:280918	21/55 (38%)
		PDZ_signaling	488..568	CDD:238492	64/79 (81%)
		SH3_CASK	616..677	CDD:213014	42/60 (70%)
		Guanylate_kin	733..906	CDD:279019	122/172 (71%)
		GuKc	743..909	CDD:214504	113/165 (68%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	264	1.000	Domainoid score	I1870
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D364535at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_105717
Panther	1	1.100	-	-	O	PTHR23122
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.920