DRSC/TRiP Functional Genomics Resources

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Protein Alignment GABA-B-R2 and Gabbr2

DIOPT Version :9

Sequence 1:NP_001287456.1 Gene:GABA-B-R2 / 42561 FlyBaseID:FBgn0027575 Length:1224 Species:Drosophila melanogaster
Sequence 2:NP_113990.2 Gene:Gabbr2 / 83633 RGDID:619864 Length:940 Species:Rattus norvegicus


Alignment Length:1015 Identity:368/1015 - (36%)
Similarity:538/1015 - (53%) Gaps:149/1015 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly    12 LLFLLLWST--ACG--RTAKR-----SDVYIAGFFPYGDGVENSYTGRGVMPSVKLALGHV-NEH 66
            ||.||||..  |.|  |.|.|     ..:.|.|..|....|.....||||:|:|:||:..: || 
  Rat    27 LLSLLLWLAPGAWGWTRGAPRPPPSSPPLSIMGLMPLTKEVAKGSIGRGVLPAVELAIEQIRNE- 90

  Fly    67 GKILANYRLHMWWNDTQCNAAVGVKSFFDMMHSGPNKVMLFGAACTHVTDPIAKASKHWHLTQLS 131
             .:|..|.|.:...||:|:.|.|:|:|:|.:..|||.:|:||..|..||..||::.:.|:|.|||
  Rat    91 -SLLRPYFLDLRLYDTECDNAKGLKAFYDAIKYGPNHLMVFGGVCPSVTSIIAESLQGWNLVQLS 154

  Fly   132 YADTHPMFT-KDAFPNFFRVVPSENAFNAPRLALLKEFNWTRVGTVYQNEPRYSLPHNHMVADLD 195
            :|.|.|:.. |..:|.|||.|||:||.|...|.|||.|.|.||||:.|:..|:|...|.:...|.
  Rat   155 FAATTPVLADKKKYPYFFRTVPSDNAVNPAILKLLKHFRWRRVGTLTQDVQRFSEVRNDLTGVLY 219

  Fly   196 AMEVEVVETQSFVNDVAESLKKLREKDVRIILGNFNEHFARKAFCEAYKLDMYGRAYQWLIMATY 260
            ..::|:.:|:||.||...|:|||:..|||||||.|:::.|.|.||.|::..|:|..|||:|...|
  Rat   220 GEDIEISDTESFSNDPCTSVKKLKGNDVRIILGQFDQNMAAKVFCCAFEESMFGSKYQWIIPGWY 284

  Fly   261 STDWWN----VTQDSECSVEEIATALEGAILVDLLPLSTSGDITVAGITADEYLVEYDRLR-GTE 320
            ...||.    ....|.|....:..|:||.|.||..|||:....|::|.|..:|..||:..| |..
  Rat   285 EPAWWEQVHVEANSSRCLRRSLLAAMEGYIGVDFEPLSSKQIKTISGKTPQQYEREYNSKRSGVG 349

  Fly   321 YSRFHGYTYDGIWAAALAIQYV-----AEKREDLLTHFDYRVKDWESVFLEALRNTSFEGVTGPV 380
            .|:||||.|||||..|..:|..     |..|...:..|:|.......:.|.|:..|:|.||||.|
  Rat   350 PSKFHGYAYDGIWVIAKTLQRAMETLHASSRHQRIQDFNYTDHTLGKIILNAMNETNFFGVTGQV 414

  Fly   381 RFYNNERKANILINQFQLGQMEKIGEYHSQKSHLDLSLGKPVKWVGKTPPKDRTLIYIEHSQVNP 445
            .|.|.||...|...|||..:..|:|||::....|:: :...:::.|..||||:|:|..:..:::.
  Rat   415 VFRNGERMGTIKFTQFQDSREVKVGEYNAVADTLEI-INDTIRFQGSEPPKDKTIILEQLRKISL 478

  Fly   446 TIYIVSASASVIGVIIATVFLAFNIKYRNQRYIKMSSPHLNNLIIVGCMMTYLSIIFLGLDTTLS 510
            .:|.:.::.:::|:|:|:.||.||||.|||:.||||||::|||||:|.|::|.||...|||.:..
  Rat   479 PLYSILSALTILGMIMASAFLFFNIKNRNQKLIKMSSPYMNNLIILGGMLSYASIFLFGLDGSFV 543

  Fly   511 SVAAFPYICTARAWILMAGFSLSFGAMFSKTWRVHSIFTDLKLNKKVIKDYQLFMVVGVLLAIDI 575
            |...|..:||.|.|||..|::.:|||||:||||||:||.::|:.||:|||.:|.::||.:|.||:
  Rat   544 SEKTFETLCTVRTWILTVGYTTAFGAMFAKTWRVHAIFKNVKMKKKIIKDQKLLVIVGGMLLIDL 608

  Fly   576 AIITTWQIADPFYR--ETKQLEPLHHENID----DVLVIPENEYCQSEHMTIFVSIIYAYKGLLL 634
            .|:..||..||..|  |...:||      |    |:.:.|..|:|::.||||::.|:|||||||:
  Rat   609 CILICWQAVDPLRRTVERYSMEP------DPAGRDISIRPLLEHCENTHMTIWLGIVYAYKGLLM 667

  Fly   635 VFGAFLAWETRHVSIPALNDSKHIGFSVYNVFITCLAGAAISLVLSDRKDLVFVLLSFFIIFCTT 699
            :||.|||||||:||||||||||:||.|||||.|.|:.|||:|.:..|:.::.|.:::..||||:|
  Rat   668 LFGCFLAWETRNVSIPALNDSKYIGMSVYNVGIMCIIGAAVSFLTRDQPNVQFCIVALVIIFCST 732

  Fly   700 ATLCLVFVPKVRLVLVELKRNPQGVV-DKRVRATLRPMSKNGRRDSSVCELEQ----RLRDVKNT 759
            .|||||||||    |:.|:.||.... ::|.:.|.....::.:..:||..:.|    ||..:::.
  Rat   733 ITLCLVFVPK----LITLRTNPDAATQNRRFQFTQNQKKEDSKTSTSVTSVNQASTSRLEGLQSE 793

  Fly   760 NCRFRKALMEKENELQALIRKL--GPEARKWIDGVTCTGGSNVGSELEPILNDDIVRLSAPPVRR 822
            |.|.|..:.|.:.:|:.:..:|  .||...:|.       .|...||     :||:.|.      
  Rat   794 NHRLRMKITELDKDLEEVTMQLQDTPEKTTYIK-------QNHYQEL-----NDILSLG------ 840

  Fly   823 EMPSTTVTEMT-SVDSVTSTHVEMDNSFVSVQSTVMAPSLPPKKKKQSIVEHHSHAPAPTMMQPI 886
                 ..||.| ...::...|::.:            |.|          :.::..|:.|...||
  Rat   841 -----NFTESTDGGKAILKNHLDQN------------PQL----------QWNTTEPSRTCKDPI 878

  Fly   887 QQ-QLQQHLQQHQQMQQQHLQQQQHQQMQQQQQQQQHHHRHLEKRNSVSAQTDDNIGSITSTAGK 950
            :. ...:|:|:...:|...|                 ||.:|           .:||.:      
  Rat   879 EDINSPEHIQRRLSLQLPIL-----------------HHAYL-----------PSIGGV------ 909

  Fly   951 RSGGDCSSMRERRQSTASRHYDSGSQTPTARPKYSSSHRN 990
                                 |:...:|...|..|..||:
  Rat   910 ---------------------DASCVSPCVSPTASPRHRH 928

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GABA-B-R2NP_001287456.1 PBP1_GABAb_receptor 32..418 CDD:107361 159/397 (40%)
ANF_receptor 52..396 CDD:279440 144/355 (41%)
7tm_3 459..712 CDD:278433 138/258 (53%)
Gabbr2NP_113990.2 PBP1_GABAb_receptor 57..459 CDD:380589 159/404 (39%)
7tmC_GABA-B-R2 479..748 CDD:320421 142/278 (51%)
TM helix 1 480..504 CDD:320421 8/23 (35%)
TM helix 2 516..537 CDD:320421 11/20 (55%)
TM helix 3 553..575 CDD:320421 12/21 (57%)
TM helix 4 598..614 CDD:320421 6/15 (40%)
TM helix 5 652..675 CDD:320421 15/22 (68%)
TM helix 6 688..710 CDD:320421 14/21 (67%)
TM helix 7 717..742 CDD:320421 13/24 (54%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 762..789 6/26 (23%)
GBR2_CC 778..816 CDD:375881 8/37 (22%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C166344237
Domainoid 1 1.000 283 1.000 Domainoid score I1570
eggNOG 1 0.900 - - E1_KOG1055
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H55902
Inparanoid 1 1.050 592 1.000 Inparanoid score I946
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D267884at33208
OrthoFinder 1 1.000 - - FOG0005571
OrthoInspector 1 1.000 - - oto98475
orthoMCL 1 0.900 - - OOG6_102670
Panther 1 1.100 - - LDO PTHR10519
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X5209
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
1514.760

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