DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GABA-B-R2 and LOC560647

DIOPT Version :9

Sequence 1:	NP_001287456.1	Gene:	GABA-B-R2 / 42561	FlyBaseID:	FBgn0027575	Length:	1224	Species:	Drosophila melanogaster
Sequence 2:	XP_021322611.1	Gene:	LOC560647 / 560647	-ID:	-	Length:	903	Species:	Danio rerio

Alignment Length:	783	Identity:	261/783 - (33%)
Similarity:	423/783 - (54%)	Gaps:	70/783 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 GRG-----VMPSVKLALGHVNEHGKILANYRLHMWWNDTQCNAAVGVKSFFDMMHSGPNKVMLFG 108
            |:|     |:|:|:|||.|::|....||||.|.....|::|:.:..:|:||:.:.|||..:|:||
Zfish    43 GKGNITAEVLPAVELALQHLSEQTSNLANYELQFHLTDSECDNSKALKAFFETIFSGPKPLMIFG 107

  Fly   109 AACTHVTDPIAKASKHWHLTQLSYADTHPMFT-KDAFPNFFRVVPSENAFNAPRLALLKEFNWTR 172
            .||:.||..:|::.:.|:|.|||:|.|.|:.. |..||||||.|||::|.|...:..|:::.|:|
Zfish   108 GACSSVTSVLAQSLESWNLVQLSFAVTVPLLADKRRFPNFFRTVPSDSAVNVALVRFLRQYGWSR 172

  Fly   173 VGTVYQNEPRYSLPHNHMVADLDAMEVEVVETQSFVNDVAESLKKLREKDVRIILGNFNEHFARK 237
            |||:.|.|..::.....:...|:...:::.|.:||.....:.:|||::.||||::.:|::..|.|
Zfish   173 VGTLTQREQSFTEVQTDLNRHLEEANIQLAEAESFSEAPCDCVKKLKDNDVRIVIAHFDQSLAAK 237

  Fly   238 AFCEAYKLDMYGRAYQWLIMATYSTDWWNVTQDSECSVEEIATALEGAILVDLLPLSTSGDITVA 302
            .||..|.:.|||:.|||::.....:..|.....:.|:.|.|.||:||:|..|:..||:|....::
Zfish   238 VFCCIYNVKMYGQKYQWILPEWVQSSRWTDIDSTNCTSENILTAIEGSISADIESLSSSHIRGIS 302

  Fly   303 GITADEYLVEYDRLRGTEY---SRFHGYTYDGIWAAALAIQYVAEK---REDLLTHFDYRVKDWE 361
            |.|..||..||:..|..:.   |:|||:.|||.|..|.|:..|.|.   ||....|.::.:.|.|
Zfish   303 GRTPQEYEKEYNERRQMKQLGGSKFHGFAYDGTWVIAKALTRVMETVKYRERYSVHRNFTLTDQE 367

  Fly   362 --SVFLEALRNTSFEGVTGPVRFYNNERKANILINQFQLGQMEKIGEYHSQKSHLDLSLGKPVKW 424
              .:.|||:...:|.||||.|.|...||.||:...|:|.|:...|.:|.:....|:..  .|:::
Zfish   368 VGQMILEAMDKINFFGVTGHVMFQKGERVANVKFAQYQDGKAVDIEKYSAITDELEFI--SPIRF 430

  Fly   425 VGKTPPKDRTLIYIEHSQVNPTIYIVSASASVIGVIIATVFLAFNIKYRNQRYIKMSSPHLNNLI 489
            ....|.||||.:|....:::..:|.:.:..:.:|:..|.:||.|::|:|:...|.||.|.:|:||
Zfish   431 HKDKPTKDRTHVYPHRKRISILLYAIVSFLTFLGIFTACIFLVFSLKHRSHWAISMSRPLMNSLI 495

  Fly   490 IVGCMMTYLSIIFLGLDTTLSSVAAFPYICTARAWILMAGFSLSFGAMFSKTWRVHSIFTDLKLN 554
            |:|.:::|.||.|:|||.:..|...|...||.:...|..|.:.:|||||:|.|::|..|.:..::
Zfish   496 ILGAVLSYSSIFFMGLDGSYVSDRVFEVSCTVQISCLSIGCTTAFGAMFAKIWQIHLFFKNHSID 560

  Fly   555 KKVIKDYQLFMVVGVLLAIDIAIITTWQIADPFYRETKQLEPLHHENIDDVLVIPENEYCQSEHM 619
            ||..|:|...::|.:|..||::::.:.|:.|||.|..|:.....|.:..|..:.|.:|.|::.|.
Zfish   561 KKNTKNYGPNLLVILLFLIDLSLLISLQVLDPFRRTVKEYRIQPHPHGQDFFIQPFSERCENTHG 625

  Fly   620 TIFVSIIYAYKGLLLVFGAFLAWETRHVSIPALNDSKHIGFSVYNVFITCLAGAAISLVLSDRKD 684
            ..:::..|.|||.||:...||||.|||::|||:|||:.|.|||:......|.|...|:....|.:
Zfish   626 LFWMAAFYIYKGTLLLSTCFLAWSTRHMNIPAVNDSRSIRFSVFVSVPVILIGTCASMFWQHRPN 690

  Fly   685 LVFVLLSFFIIFCTTATLCLVFVPKVRLVLV------------------ELKRNPQGVVDKRVRA 731
            :.|.:::..|:.|...|||:|||||:.::.:                  ||::..:...|||
Zfish   691 VQFCIVTLVIVTCCCCTLCMVFVPKIIIIRMGPDPAFLSRRFHLKQWHSELEKETEQNKDKR--- 752

  Fly   732 TLRPMSKNGRRDSSVCELEQR------------------LRDVKNTNCRFRKALMEKENELQALI 778
                           |.||||                  |...::.|...|:.:...::||:.|.
Zfish   753 ---------------CMLEQRDPGLSVFMIDATLSISSSLTIHQSENLYLRRHINYLDSELEDLT 802

  Fly   779 RKL 781
            |:|
Zfish   803 RQL 805

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GABA-B-R2	NP_001287456.1	PBP1_GABAb_receptor	32..418	CDD:107361	139/382 (36%)
		ANF_receptor	52..396	CDD:279440	131/352 (37%)
		7tm_3	459..712	CDD:278433	95/252 (38%)
LOC560647	XP_021322611.1	PBP1_GABAb_receptor	35..407	CDD:107361	135/363 (37%)
		7tm_GPCRs	453..720	CDD:333717	97/266 (36%)
		TM helix 1	453..477	CDD:320095	6/23 (26%)
		TM helix 2	489..510	CDD:320095	10/20 (50%)
		TM helix 3	526..548	CDD:320095	9/21 (43%)
		TM helix 4	571..587	CDD:320095	4/15 (27%)
		TM helix 5	625..648	CDD:320095	8/22 (36%)
		TM helix 6	658..683	CDD:320095	9/24 (38%)
		TM helix 7	690..715	CDD:320095	9/24 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D267884at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010