DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GABA-B-R2 and gabbr2

DIOPT Version :9

Sequence 1:	NP_001287456.1	Gene:	GABA-B-R2 / 42561	FlyBaseID:	FBgn0027575	Length:	1224	Species:	Drosophila melanogaster
Sequence 2:	NP_001137515.1	Gene:	gabbr2 / 560267	ZFINID:	ZDB-GENE-060503-620	Length:	935	Species:	Danio rerio

Alignment Length:	964	Identity:	342/964 - (35%)
Similarity:	526/964 - (54%)	Gaps:	117/964 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 PYGDGVENSYTGRGVMPSVKLALGHVNEHGKILANYRLHMWWNDTQCNAAVGVKSFFDMMHSGPN 102
            |..:....|...:|:.|:|:||:.|:.|..:.  ::.|.....||:|:.|.|:::|||.:..||.
Zfish    61 PMNESALMSSISQGIEPAVQLAIQHIRESRQY--SFSLITKIYDTECDNAKGLRAFFDAICYGPK 123

  Fly   103 KVMLFGAACTHVTDPIAKASKHWHLTQLSYADTHPMFT-KDAFPNFFRVVPSENAFNAPRLALLK 166
            .:|:||..|..||..||::.:.|:|.|||:|.|.|:.. :..:|||||.|||:||.|...:..|.
Zfish   124 HLMIFGGVCPSVTSIIAESLEGWNLVQLSFAATTPVLADRKKYPNFFRTVPSDNAVNPAVVKFLN 188

  Fly   167 EFNWTRVGTVYQNEPRYSLPHNHMVADLDAMEVEVVETQSFVNDVAESLKKLREKDVRIILGNFN 231
            .:||:||||:.|:..|:|...|.:..:|:..::::.:|:||.||...::|||::.|||||:|.|:
Zfish   189 FYNWSRVGTLTQDVQRFSEVRNDLTNELEKADIQIADTESFSNDPCVNVKKLKDNDVRIIIGQFD 253

  Fly   232 EHFARKAFCEAYKLDMYGRAYQWLIMATYSTDWWNVTQDSECSVEEIATALEGAILVDLLPLSTS 296
            |:.|.|.||.||.|:|||..|||:|...|..:||.....:.|:..::.||:||.|.||..|||..
Zfish   254 ENLAAKVFCCAYNLNMYGSKYQWIIPGWYQGNWWEQANSTNCTTRKLLTAMEGYISVDFEPLSAK 318

  Fly   297 GDITVAGITADEYLVEYDRLR---GTEYSRFHGYTYDGIWAAALAIQYVAE-----KREDLLTHF 353
            ....::|.|..||..||:|.|   |.|.|:|||:.|||||..|..:..|.|     :|.|:..:|
Zfish   319 QIKGISGRTPQEYEREYNRERDQKGVETSKFHGFAYDGIWVIAKTLTRVMELLRHKERHDMYHNF 383

  Fly   354 DYRVKDWESVFLEALRNTSFEGVTGPVRFYNNERKANILINQFQLGQMEKIGEYHSQKSHLDLSL 418
            ....::...:.|:.:..|:|.||||.|.|.|.||...|...|||.||..|:|||::....||| :
Zfish   384 TVDDREVGKMVLDVMNETNFFGVTGQVMFRNGERMGTIKFTQFQEGQEVKVGEYNAIADVLDL-I 447

  Fly   419 GKPVKWVGKTPPKDRTLIYIEHSQVNPTIYIVSASASVIGVIIATVFLAFNIKYRNQRYIKMSSP 483
            ...:::.|..||||||.:.::..|:|..:|.:.::.:::|:::...||.||||.||.|.||||||
Zfish   448 NNTIRFQGVEPPKDRTFVRLQRRQINVPLYSILSTITILGMLMGGAFLFFNIKNRNHRLIKMSSP 512

  Fly   484 HLNNLIIVGCMMTYLSIIFLGLDTTLSSVAAFPYICTARAWILMAGFSLSFGAMFSKTWRVHSIF 548
            ::|||||:|.|::|.||...|||.:..|...|..:||.|.|||:.|::.:|||||:||||||:||
Zfish   513 YMNNLIILGGMLSYASIFLFGLDGSFVSDKEFETLCTVRTWILIVGYTTAFGAMFAKTWRVHAIF 577

  Fly   549 TDLKLNKKVIKDYQLFMVVGVLLAIDIAIITTWQIADPFYRETKQLEPLHHENIDDVLVIPENEY 613
            .::|:.||:|||.:||::||.:|.||:.|:..|||.||..|..::..........|:.:.|..|:
Zfish   578 KNVKMKKKIIKDQKLFIIVGGMLLIDLCILICWQIVDPLKRTVEEYSLEADPQGRDIAIRPFLEH 642

  Fly   614 CQSEHMTIFVSIIYAYKGLLLVFGAFLAWETRHVSIPALNDSKHIGFSVYNVFITCLAGAAISLV 678
            |::.||||::.|:|||||||::||.|||||||:||||||||||:||.|||||.|.|:.|||:|.:
Zfish   643 CENTHMTIWLGIVYAYKGLLMLFGCFLAWETRNVSIPALNDSKYIGMSVYNVGIMCIIGAAVSFL 707

  Fly   679 LSDRKDLVFVLLSFFIIFCTTATLCLVFVPKVRLVLVELKRNPQGVV-DKRVRATLRPMSKNGRR 742
            ..|:.::.|.:::..||||:|.|||||||||    .|.::.||.... ::|::.|.....::.:.
Zfish   708 TRDQPNVQFCIVALVIIFCSTITLCLVFVPK----FVTMRTNPDAATQNRRLKFTQNQKKEDSKT 768

  Fly   743 DSSVCELEQ----RLRDVKNTNCRFRKALMEKENELQALIRKLGPEARKWIDGVTCTGGSNVGSE 803
            .:||..:.|    ||..:::.|.|.|..:.|.:.||:.:..:|
Zfish   769 STSVTSVNQANTSRLDGLQSDNHRLRMKITELDKELEEVTMQL---------------------- 811

  Fly   804 LEPILNDDIVRLSAPPVRREMPSTTVTEMTSVDSVTSTHVEMDNSFVSVQSTVMAPSLPPKKKKQ 868
                              ::.|..|       ..:...|.:..|:.:|:::.
Zfish   812 ------------------QDTPEKT-------PYIKQNHYQDANNILSIRNF------------- 838

  Fly   869 SIVEHHSHAPAPTMMQPIQQQLQQHLQQHQQMQ-------------QQHLQQQQHQQMQQQQQQQ 920
                        |..:..::.|:.||:|..|.|             .:.:...:|.|.:...|..
Zfish   839 ------------TDGKDGEKSLKNHLEQKPQAQWGSADPSRISRGPLEDINSPEHIQRRLSLQLP 891

  Fly   921 QHHHRHLEKRNSVSAQTDDNIGSITSTAGKRSGGDCSSMRERRQSTASRHYDSG 974
            ..||.:|           .:||.:.::....:....||.|.|....:.|...||
Zfish   892 ILHHAYL-----------PSIGGVDASCSSPTSSPSSSPRHRHMPPSYRVMVSG 934

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GABA-B-R2	NP_001287456.1	PBP1_GABAb_receptor	32..418	CDD:107361	153/388 (39%)
		ANF_receptor	52..396	CDD:279440	138/352 (39%)
		7tm_3	459..712	CDD:278433	134/252 (53%)
gabbr2	NP_001137515.1	PBP1_GABAb_receptor	58..440	CDD:107361	150/380 (39%)
		ANF_receptor	76..419	CDD:279440	137/344 (40%)
		7tm_3	488..739	CDD:278433	134/254 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585302
Domainoid	1	1.000	284	1.000	Domainoid score	I1598
eggNOG	1	0.900	-	-		E1_KOG1055
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55902
Inparanoid	1	1.050	612	1.000	Inparanoid score	I880
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D267884at33208
OrthoFinder	1	1.000	-	-		FOG0005571
OrthoInspector	1	1.000	-	-		oto39161
orthoMCL	1	0.900	-	-		OOG6_102670
Panther	1	1.100	-	-	LDO	PTHR10519
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3137
SonicParanoid	1	1.000	-	-		X5209
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.790