DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GABA-B-R2 and gabbr1b

DIOPT Version :9

Sequence 1:	NP_001287456.1	Gene:	GABA-B-R2 / 42561	FlyBaseID:	FBgn0027575	Length:	1224	Species:	Drosophila melanogaster
Sequence 2:	XP_005170159.1	Gene:	gabbr1b / 558708	ZFINID:	ZDB-GENE-060503-5	Length:	994	Species:	Danio rerio

Alignment Length:	856	Identity:	272/856 - (31%)
Similarity:	441/856 - (51%)	Gaps:	85/856 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 FLLLW--STACGRTAK----------------RSDVYIAGFFPYGDGVENSYTGRGVMPSVKLAL 60
            |:|:.  ||.|.:..|                :..:||...||...|...   |:..:|:.::||
Zfish   131 FILVGRNSTQCNKLGKWDSPKPVCHYDRHYTGKKKLYIGALFPMSGGWPG---GQACLPAAQMAL 192

  Fly    61 GHVNEHGKILANYRLHMWWNDTQCNAAVGVKSFFDMMHSGPNKVMLFGAACTHVTDPIAKASKHW 125
            ..||:...||.:|.|.:...|:.|:.....|..:|::::.|.|::|. ..|:.|:..:|:|::.|
Zfish   193 DLVNKRTDILPDYELELIHYDSMCDPGEATKLLYDLLYTEPIKIVLM-PGCSSVSTLVAEAARMW 256

  Fly   126 HLTQLSYADTHP-MFTKDAFPNFFRVVPSENAFNAPRLALLKEFNWTRVGTVYQNEPRYSLPHNH 189
            :|..|||..:.| :..:..||.|||..||....|..|:.|.:::.||::.|:.|....::
Zfish   257 NLIVLSYGSSSPALSNRQRFPTFFRTHPSATLHNPTRVQLFQKWKWTKIATIQQTTEVFT----- 316

  Fly   190 MVADLDAME-------VEVVETQSFVNDVAESLKKLREKDVRIILGNFNEHFARKAFCEAYKLDM 247
              :.||.:|       :|:...|||:.|.|.::|.|:.:|.|||:|.|.|..|||.|||.||..:
Zfish   317 --STLDDLEQRVKEAGIEISVRQSFLTDPAVAVKNLKRQDARIIVGLFYETEARKVFCEVYKEKL 379

  Fly   248 YGRAYQWLIMATYSTDWWNVTQDS-ECSVEEIATALEGAILVDLLPLSTSGDITVAG---ITADE 308
            ||:.|.|.::..|:.:|:.:...| .|:||::..|:||.:..:::.|:..   ||.|   :|:.|
Zfish   380 YGKKYVWFLIGWYADNWFKIKDPSINCTVEQMTEAVEGHVTTEIVMLNPE---TVRGASNLTSQE 441

  Fly   309 YLVE-YDRLRGTEYSRFHGY-----TYDGIWAAALAIQYV-----AEKREDLLTHFDYRVKDWES 362
            :|.: ..:|.|.......|:     .||.:||.|||:...     |:.|.  |..|:|..||..:
Zfish   442 FLAQLMSKLGGKNPEETGGFQEAPLAYDAVWALALALNKTVGPLKAKGRR--LEDFNYNNKDITA 504

  Fly   363 VFLEALRNTSFEGVTGPVRF-YNNERKANILINQFQLGQMEKIGEYHSQKSHLDLSLGKPVKWVG 426
            ....||..:|||||:|.|.| ....|.|..||.|.|.|..:|||.|...|.:|.. .|.. :|:|
Zfish   505 EIYRALNTSSFEGVSGHVVFDAQGSRMAWTLIEQLQGGSYKKIGYYDMTKGNLSW-YGND-RWIG 567

  Fly   427 KTPPKDRTLIYIEHSQVNPTIYIVSASASVIGVIIATVFLAFNIKYRNQRYIKMSSPHLNNLIIV 491
            ..||.|:|::..:...::..:::..:..:.:|:::..|.|.|||...|.|||:.|.|:|||:..|
Zfish   568 SGPPADQTVVIQKFRYLSQKLFVSVSVFAGLGILMGIVCLTFNIYNSNVRYIQNSQPYLNNMTAV 632

  Fly   492 GCMMTYLSIIFLGLDTTLSSVAAFPYICTARAWILMAGFSLSFGAMFSKTWRVHSIFT--DLKLN 554
            ||||...::..||:|......:.||.:|..|.|:|..||||::|:||:|.|.||::||  |.|.:
Zfish   633 GCMMALAAVFPLGIDGLHVRNSQFPVVCQFRLWLLGLGFSLAYGSMFTKIWWVHTVFTKKDEKKD 697

  Fly   555 KKV--IKDYQLFMVVGVLLAIDIAIITTWQIADPFYRETKQLEPLHHENIDDVLVIPENEYCQSE 617
            |:.  ::.::|:..|||||.|||..:..|||.||.:...::......:...|.|:.|..::|.||
Zfish   698 KRKQHLEPWKLYATVGVLLVIDILSLMIWQIVDPLHITVEKFTKEAPKGDVDELIEPLLQHCSSE 762

  Fly   618 HMTIFVSIIYAYKGLLLVFGAFLAWETRHVSIPALNDSKHIGFSVYNVFITCLAGAAISLVLSDR 682
            .|..::.::|.||||||:.|.|||:||:.||...:||.:.:|.::|||.:.|:..|.::::||.:
Zfish   763 KMNTWLGVVYGYKGLLLLLGIFLAYETKSVSTEKINDHRAVGMAIYNVSVLCMITAPVTMILSSK 827

  Fly   683 KDLVFVLLSFFIIFCTTATLCLVFVPKVRLVLVELKRNPQGVVDKRVRATLRPMSKNGRRDSSVC 747
            :|..|...|..|||....||.::||||:|.::.      :|......:.|::..|.....|
Zfish   828 QDASFAFASLAIIFSVYITLVVLFVPKMRRLIT------RGEWQSDQQETMKTGSSTNNND---- 882

  Fly   748 ELEQRLRDVKNTNCRFRKALMEKENELQALIRKLGP----EARKWIDGVTCTGGSNVGSELEPIL 808
              |::.|.::..|...:|.:.|||..:..|..:|..    .:||     ..|...|..|...|..
Zfish   883 --EEKSRQLERENKELQKIIQEKEERVSELRNQLSERQALRSRK-----RPTSNQNHSSPSIPTP 940

  Fly   809 NDDIVRLSAPP 819
            .:|...|..||
Zfish   941 QNDPKSLLPPP 951

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GABA-B-R2	NP_001287456.1	PBP1_GABAb_receptor	32..418	CDD:107361	132/409 (32%)
		ANF_receptor	52..396	CDD:279440	117/367 (32%)
		7tm_3	459..712	CDD:278433	102/256 (40%)
gabbr1b	XP_005170159.1	CCP	97..154	CDD:214478	6/22 (27%)
		PBP1_GABAb_receptor	167..560	CDD:107361	132/409 (32%)
		ANF_receptor	183..540	CDD:279440	118/369 (32%)
		7tm_3	600..855	CDD:278433	101/254 (40%)
		DD_cGKI	895..>923	CDD:213458	6/27 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1055
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D267884at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820