DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GABA-B-R2 and Gpr156

DIOPT Version :9

Sequence 1:	NP_001287456.1	Gene:	GABA-B-R2 / 42561	FlyBaseID:	FBgn0027575	Length:	1224	Species:	Drosophila melanogaster
Sequence 2:	NP_695207.2	Gene:	Gpr156 / 260430	RGDID:	708438	Length:	792	Species:	Rattus norvegicus

Alignment Length:	839	Identity:	193/839 - (23%)
Similarity:	318/839 - (37%)	Gaps:	181/839 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   420 KPVKWVGKTPPKDRTLIYIEHSQVNPTIYIVSASASVIGVIIATVFLAFNIKYRNQRYIKMSSPH 484
            :|:..:.||...|......:.|.::|.:..|..:....|:::...||||.|:.|..|.:|||||:
  Rat    22 RPLHDLCKTTITDSQHGSADISPLSPALLGVIWTFLSCGLLLVLFFLAFTIRCRKNRIVKMSSPN 86

  Fly   485 LNNLIIVGCMMTYLSIIFLGLDTTL--SSVAAFPYICTARAWILMAGFSLSFGAMFSKTWRVHSI 547
            ||.:.::|..:||.|....|:...|  |||.|   :...|..:|..|.:|.||.:..|:||::.:
  Rat    87 LNIVTLLGSCLTYSSAYLFGIQDALVGSSVEA---LIQTRLSLLCIGTTLVFGPILGKSWRLYKV 148

  Fly   548 FTDLKLNKKV-IKDYQLFMVVGVLLAIDIAIITTWQIADPFYRETKQL--EPLHHENIDDVLVIP 609
            ||....:|:| |||.||..:|..|:..|:.::.||.:.||.  :..|:  ..:.....|....:.
  Rat   149 FTQRVPDKRVIIKDLQLLGLVAALVVADVILLVTWVLTDPI--QCLQILGVSMKVTGRDVSCSLT 211

  Fly   610 ENEYCQSEHMTIFVSIIYAYKGLLLVFGAFLAWETRHVSIPALNDSKHIGFSVYNVFITCLAGAA 674
            ...:|.|.:..::::::...|||||::||:||..|.|||.|.:|.|..|...|..:.:|......
  Rat   212 NTHFCASRYSDVWIALVLGCKGLLLLYGAYLAGLTNHVSSPPVNQSLTIMVGVNLLLLTAGLLFV 276

  Fly   675 ISLVLSDRKDLVFVLLSFFIIFCTTATLCLVFVPKVRLVLVELKRNPQGVVDKRVRATLRPMSKN 739
            ::..|....:|||.|.|..|..|||...|.||:|::|          |....:....|:|.|:|.
  Rat   277 VTRYLHSWPNLVFGLTSGGIFVCTTTVNCCVFLPQLR----------QRKAFEGENQTIRHMAKY 331

  Fly   740 GRRDSSVCELEQRLRDVKNTNCRFRKALMEK-ENELQALIRKLGPEARKWIDGVTCTGGSNVGSE 803
            ....|..  ...:..:.::.:.|..|:.||: ..|..|:|..|..:.            ||...:
  Rat   332 FSTPSKT--FRSKFDEDQSCHLRDEKSCMERLLTEKNAVIESLQEQV------------SNAKEK 382

  Fly   804 LEPILNDDIVRLSAP----------------PVRREMPSTTVTEMTSVDSVTSTHVEMDNSFVSV 852
            |..:::.:.. |.:|                |...|..|....|.:...|..|.|::...:
  Rat   383 LVKLMSAECA-LDSPEWAVPAAASAGGPAECPATSEKESGAAAEDSLPASAASQHMQGPGA---- 442

  Fly   853 QSTVMAPSLPPKKKKQSIVEHHSHAPAPTMMQPIQQQL-------QQHLQQHQQMQQQHLQQQQH 910
             |...|...|.:|....:.:...|.......:|..:|.       |:.:...|.:....:..:.|
  Rat   443 -SRRDASPSPDQKYDMPLKQFCDHLDMGCSQKPKAEQSEGPERGNQEPMAPGQSLMTDGVACEPH 506

  Fly   911 QQMQQQQQQQQHHHRHLEKRNSVSAQTDDNIGSITSTAGKRSGGDCSSMRERRQSTASRHYDSGS 975
            :..|..:...:    .|.:.:||                         :||:.|... :..|.|:
  Rat   507 RPRQNSEVLPE----RLPRVSSV-------------------------VREKLQEVL-QELDLGT 541

  Fly   976 QTPTARPKYSSSHRNSSTNISTSQSELSNMCPHSKPSTPAVIKTPTASDHRRT--------SMGS 1032
            :.|.:  ......:...:|.|.|..:||   |.....:|.|::...|:...|:        .||.
  Rat   542 EAPLS--PLPCPQQPWKSNTSGSPQKLS---PSKLGFSPYVVRRRRAAQRARSRIPGSVGLKMGH 601

  Fly  1033 ALKSNFVVSQSDLWDTHTLSHAKQRQSPRNYASPQRCAEHHGGHGMTYDPNTTSPIQRSVSEKNR 1097
            ...:....||:.|       ..:.|.|||        .:||         |..|...||.|.|..
  Rat   602 QANNTVSGSQNGL-------IVQNRDSPR--------LDHH---------NARSKEPRSSSVKPS 642

  Fly  1098 NKHRPKPQKGTV---CQSETDSERERDPPPNSQPCVQPRKVSRSSNIQHAAHHHSSPNVAPDKQR 1159
            ....|..::|::   .|.||:.:..|     ......||:.|.|               ||
  Rat   643 PISAPHQRRGSLEGSKQCETEPQEAR-----GYSVAFPRQPSAS---------------AP---- 683

  Fly  1160 SRQRGKQDSSIYGASSETELLEGETAILPIFRKLLTEKSPNYRGRSAVGQSCPNISIKC 1218
                         |.|.|......:..||..|:.|...||          .||::|..|
  Rat   684 -------------AQSSTAPCLSSSPALPRQRQPLPLLSP----------GCPSLSSGC 719

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GABA-B-R2	NP_001287456.1	PBP1_GABAb_receptor	32..418	CDD:107361
		ANF_receptor	52..396	CDD:279440
		7tm_3	459..712	CDD:278433	86/257 (33%)
Gpr156	NP_695207.2	7tmC_GPR156	48..317	CDD:320419	90/283 (32%)
		TM helix 1	49..73	CDD:320419	6/23 (26%)
		TM helix 2	85..106	CDD:320419	7/20 (35%)
		TM helix 3	121..143	CDD:320419	7/21 (33%)
		TM helix 4	167..183	CDD:320419	3/15 (20%)
		TM helix 5	221..244	CDD:320419	8/22 (36%)
		TM helix 6	253..275	CDD:320419	5/21 (24%)
		TM helix 7	286..311	CDD:320419	12/24 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	407..516		18/113 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	532..705		48/239 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166344238
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1055
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10519
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.840