DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GABA-B-R2 and GABBR1

DIOPT Version :9

Sequence 1:	NP_001287456.1	Gene:	GABA-B-R2 / 42561	FlyBaseID:	FBgn0027575	Length:	1224	Species:	Drosophila melanogaster
Sequence 2:	XP_005249039.1	Gene:	GABBR1 / 2550	HGNCID:	4070	Length:	966	Species:	Homo sapiens

Alignment Length:	799	Identity:	262/799 - (32%)
Similarity:	432/799 - (54%)	Gaps:	67/799 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 WSTA---C--GRT--AKRSDVYIAGFFPYGDGVENSYTGRGVMPSVKLALGHVNEHGKILANYRL 75
            |||.   |  .||  ::|..|||...||...|...   |:...|:|::||..||....||.:|.|
Human   155 WSTPKPHCQVNRTPHSERRAVYIGALFPMSGGWPG---GQACQPAVEMALEDVNSRRDILPDYEL 216

  Fly    76 HMWWNDTQCNAAVGVKSFFDMMHSGPNKVMLFGAACTHVTDPIAKASKHWHLTQLSYADTHP-MF 139
            .:..:|::|:.....|..::::::.|.|::|. ..|:.|:..:|:|::.|:|..|||..:.| :.
Human   217 KLIHHDSKCDPGQATKYLYELLYNDPIKIILM-PGCSSVSTLVAEAARMWNLIVLSYGSSSPALS 280

  Fly   140 TKDAFPNFFRVVPSENAFNAPRLALLKEFNWTRVGTVYQNEPRYSLPHNHMVADLDAME------ 198
            .:..||.|||..||....|..|:.|.:::.|.::.|:.|....::       :.||.:|
Human   281 NRQRFPTFFRTHPSATLHNPTRVKLFEKWGWKKIATIQQTTEVFT-------STLDDLEERVKEA 338

  Fly   199 -VEVVETQSFVNDVAESLKKLREKDVRIILGNFNEHFARKAFCEAYKLDMYGRAYQWLIMATYST 262
             :|:...|||.:|.|..:|.|:.:|.|||:|.|.|..|||.|||.||..::|:.|.|.::..|:.
Human   339 GIEITFRQSFFSDPAVPVKNLKRQDARIIVGLFYETEARKVFCEVYKERLFGKKYVWFLIGWYAD 403

  Fly   263 DWWNVTQDS-ECSVEEIATALEGAILVDLLPLSTSGDITVAGITADEYLVEYDRLRGTEYSRFHG 326
            :|:.:...| .|:|:|:..|:||.|..:::.|:.:...:::.:|:.|::.:..:..........|
Human   404 NWFKIYDPSINCTVDEMTEAVEGHITTEIVMLNPANTRSISNMTSQEFVEKLTKRLKRHPEETGG 468

  Fly   327 Y-----TYDGIWAAALAIQYVA-------EKREDLLTHFDYRVKDWESVFLEALRNTSFEGVTGP 379
            :     .||.|||.|||:...:       .:.||    |:|..:........|:.::|||||:|.
Human   469 FQEAPLAYDAIWALALALNKTSGGGGRSGVRLED----FNYNNQTITDQIYRAMNSSSFEGVSGH 529

  Fly   380 VRF-YNNERKANILINQFQLGQMEKIGEYHSQKSHLDLSLGKPVKWVGKTPPKDRTLIYIEHSQV 443
            |.| .:..|.|..||.|.|.|..:|||.|.|.|.  |||..|..||:|.:||.|:||:......:
Human   530 VVFDASGSRMAWTLIEQLQGGSYKKIGYYDSTKD--DLSWSKTDKWIGGSPPADQTLVIKTFRFL 592

  Fly   444 NPTIYIVSASASVIGVIIATVFLAFNIKYRNQRYIKMSSPHLNNLIIVGCMMTYLSIIFLGLDTT 508
            :..::|..:..|.:|:::|.|.|:|||...:.|||:.|.|:||||..|||.:...::..||||..
Human   593 SQKLFISVSVLSSLGIVLAVVCLSFNIYNSHVRYIQNSQPNLNNLTAVGCSLALAAVFPLGLDGY 657

  Fly   509 LSSVAAFPYICTARAWILMAGFSLSFGAMFSKTWRVHSIFT---DLKLNKKVIKDYQLFMVVGVL 570
            ......||::|.||.|:|..||||.:|:||:|.|.||::||   :.|..:|.::.::|:..||:|
Human   658 HIGRNQFPFVCQARLWLLGLGFSLGYGSMFTKIWWVHTVFTKKEEKKEWRKTLEPWKLYATVGLL 722

  Fly   571 LAIDIAIITTWQIADPFYRETKQL---EPLHHENIDDVLVIPENEYCQSEHMTIFVSIIYAYKGL 632
            :.:|:..:..|||.||.:|..:..   ||  .|:| ||.::|:.|:|.|..|..::.|.|.||||
Human   723 VGMDVLTLAIWQIVDPLHRTIETFAKEEP--KEDI-DVSILPQLEHCSSRKMNTWLGIFYGYKGL 784

  Fly   633 LLVFGAFLAWETRHVSIPALNDSKHIGFSVYNVFITCLAGAAISLVLSDRKDLVFVLLSFFIIFC 697
            ||:.|.|||:||:.||...:||.:.:|.::|||.:.||..|.::::||.::|..|...|..|:|.
Human   785 LLLLGIFLAYETKSVSTEKINDHRAVGMAIYNVAVLCLITAPVTMILSSQQDAAFAFASLAIVFS 849

  Fly   698 TTATLCLVFVPKVRLVLVELKRNPQGVVDKRVRATLRPMSKNGRRDSSVCELEQRLRDVKNTNCR 762
            :..||.::||||:|.::.      :|......:.|::..|.....:      |::.|.::..|..
Human   850 SYITLVVLFVPKMRRLIT------RGEWQSEAQDTMKTGSSTNNNE------EEKSRLLEKENRE 902

  Fly   763 FRKALMEKENELQALIRKL 781
            ..|.:.|||..:..|..:|
Human   903 LEKIIAEKEERVSELRHQL 921

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GABA-B-R2	NP_001287456.1	PBP1_GABAb_receptor	32..418	CDD:107361	124/407 (30%)
		ANF_receptor	52..396	CDD:279440	107/365 (29%)
		7tm_3	459..712	CDD:278433	104/258 (40%)
GABBR1	XP_005249039.1	Sushi	112..162	CDD:395037	3/6 (50%)
		PBP1_GABAb_receptor	176..575	CDD:380589	128/415 (31%)
		7tmC_GABA-B-R1	595..867	CDD:320418	108/274 (39%)
		TM helix 1	596..620	CDD:320418	8/23 (35%)
		TM helix 2	632..653	CDD:320418	8/20 (40%)
		TM helix 3	669..691	CDD:320418	12/21 (57%)
		TM helix 4	717..733	CDD:320418	4/15 (27%)
		TM helix 5	771..794	CDD:320418	12/22 (55%)
		TM helix 6	807..829	CDD:320418	7/21 (33%)
		TM helix 7	836..861	CDD:320418	9/24 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1055
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D267884at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820