DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GABA-B-R2 and Gabbr2

DIOPT Version :9

Sequence 1:	NP_001287456.1	Gene:	GABA-B-R2 / 42561	FlyBaseID:	FBgn0027575	Length:	1224	Species:	Drosophila melanogaster
Sequence 2:	NP_001074610.1	Gene:	Gabbr2 / 242425	MGIID:	2386030	Length:	940	Species:	Mus musculus

Alignment Length:	1015	Identity:	365/1015 - (35%)
Similarity:	536/1015 - (52%)	Gaps:	149/1015 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 LLFLLL--------WSTACGRTAKRS-DVYIAGFFPYGDGVENSYTGRGVMPSVKLALGHV-NEH 66
            ||.|||        |:....|....| .:.|.|..|....|.....||||:|:|:||:..: ||
Mouse    27 LLSLLLSLAPGAWGWARGAPRPPPSSPPLSIMGLMPLTKEVAKGSIGRGVLPAVELAIEQIRNE- 90

  Fly    67 GKILANYRLHMWWNDTQCNAAVGVKSFFDMMHSGPNKVMLFGAACTHVTDPIAKASKHWHLTQLS 131
             .:|..|.|.:...||:|:.|.|:|:|:|.:..|||.:|:||..|..||..||::.:.|:|.|||
Mouse    91 -SLLRPYFLDLRLYDTECDNAKGLKAFYDAIKYGPNHLMVFGGVCPSVTSIIAESLQGWNLVQLS 154

  Fly   132 YADTHPMFT-KDAFPNFFRVVPSENAFNAPRLALLKEFNWTRVGTVYQNEPRYSLPHNHMVADLD 195
            :|.|.|:.. |..:|.|||.|||:||.|...|.|||.|.|.||||:.|:..|:|...|.:...|.
Mouse   155 FAATTPVLADKKKYPYFFRTVPSDNAVNPAILKLLKHFRWRRVGTLTQDVQRFSEVRNDLTGVLY 219

  Fly   196 AMEVEVVETQSFVNDVAESLKKLREKDVRIILGNFNEHFARKAFCEAYKLDMYGRAYQWLIMATY 260
            ..::|:.:|:||.||...|:|||:..|||||||.|:::.|.|.||.|::..|:|..|||:|...|
Mouse   220 GEDIEISDTESFSNDPCTSVKKLKGNDVRIILGQFDQNMAAKVFCCAFEESMFGSKYQWIIPGWY 284

  Fly   261 STDWWN----VTQDSECSVEEIATALEGAILVDLLPLSTSGDITVAGITADEYLVEYDRLR-GTE 320
            ...||.    ....|.|....:..|:||.|.||..|||:....|::|.|..:|..||:..| |..
Mouse   285 EPAWWEQVHVEANSSRCLRRSLLAAMEGYIGVDFEPLSSKQIKTISGKTPQQYEREYNSKRSGVG 349

  Fly   321 YSRFHGYTYDGIWAAALAIQYV-----AEKREDLLTHFDYRVKDWESVFLEALRNTSFEGVTGPV 380
            .|:||||.|||||..|..:|..     |..|...:..|:|.......:.|.|:..|:|.||||.|
Mouse   350 PSKFHGYAYDGIWVIAKTLQRAMETLHASSRHQRIQDFNYTDHTLGRIILNAMNETNFFGVTGQV 414

  Fly   381 RFYNNERKANILINQFQLGQMEKIGEYHSQKSHLDLSLGKPVKWVGKTPPKDRTLIYIEHSQVNP 445
            .|.|.||...|...|||..:..|:|||::....|:: :...:::.|..||||:|:|..:..:::.
Mouse   415 VFRNGERMGTIKFTQFQDSREVKVGEYNAVADTLEI-INDTIRFQGSEPPKDKTIILEQLRKISL 478

  Fly   446 TIYIVSASASVIGVIIATVFLAFNIKYRNQRYIKMSSPHLNNLIIVGCMMTYLSIIFLGLDTTLS 510
            .:|.:.::.:::|:|:|:.||.||||.|||:.||||||::|||||:|.|::|.||...|||.:..
Mouse   479 PLYSILSALTILGMIMASAFLFFNIKNRNQKLIKMSSPYMNNLIILGGMLSYASIFLFGLDGSFV 543

  Fly   511 SVAAFPYICTARAWILMAGFSLSFGAMFSKTWRVHSIFTDLKLNKKVIKDYQLFMVVGVLLAIDI 575
            |...|..:||.|.|||..|::.:|||||:||||||:||.::|:.||:|||.:|.::||.:|.||:
Mouse   544 SEKTFETLCTVRTWILTVGYTTAFGAMFAKTWRVHAIFKNVKMKKKIIKDQKLLVIVGGMLLIDL 608

  Fly   576 AIITTWQIADPFYR--ETKQLEPLHHENID----DVLVIPENEYCQSEHMTIFVSIIYAYKGLLL 634
            .|:..||..||..|  |...:||      |    |:.:.|..|:|::.||||::.|:|||||||:
Mouse   609 CILICWQAVDPLRRTVERYSMEP------DPAGRDISIRPLLEHCENTHMTIWLGIVYAYKGLLM 667

  Fly   635 VFGAFLAWETRHVSIPALNDSKHIGFSVYNVFITCLAGAAISLVLSDRKDLVFVLLSFFIIFCTT 699
            :||.|||||||:||||||||||:||.|||||.|.|:.|||:|.:..|:.::.|.:::..||||:|
Mouse   668 LFGCFLAWETRNVSIPALNDSKYIGMSVYNVGIMCIIGAAVSFLTRDQPNVQFCIVALVIIFCST 732

  Fly   700 ATLCLVFVPKVRLVLVELKRNPQGVV-DKRVRATLRPMSKNGRRDSSVCELEQ----RLRDVKNT 759
            .|||||||||    |:.|:.||.... ::|.:.|.....::.:..:||..:.|    ||..:::.
Mouse   733 ITLCLVFVPK----LITLRTNPDAATQNRRFQFTQNQKKEDSKTSTSVTSVNQASTSRLEGLQSE 793

  Fly   760 NCRFRKALMEKENELQALIRKL--GPEARKWIDGVTCTGGSNVGSELEPILNDDIVRLSAPPVRR 822
            |.|.|..:.|.:.:|:.:..:|  .||...:|.       .|...||     :||:.|.
Mouse   794 NHRLRMKITELDKDLEEVTMQLQDTPEKTTYIK-------QNHYQEL-----NDILSLG------ 840

  Fly   823 EMPSTTVTEMT-SVDSVTSTHVEMDNSFVSVQSTVMAPSLPPKKKKQSIVEHHSHAPAPTMMQPI 886
                 ..||.| ...::...|::.:            |.|          :.::..|:.|...||
Mouse   841 -----NFTESTDGGKAILKNHLDQN------------PQL----------QWNTTEPSRTCKDPI 878

  Fly   887 QQ-QLQQHLQQHQQMQQQHLQQQQHQQMQQQQQQQQHHHRHLEKRNSVSAQTDDNIGSITSTAGK 950
            :. ...:|:|:...:|...|                 ||.:|           .:||.:
Mouse   879 EDINSPEHIQRRLSLQLPIL-----------------HHAYL-----------PSIGGV------ 909

  Fly   951 RSGGDCSSMRERRQSTASRHYDSGSQTPTARPKYSSSHRN 990
                                 |:...:|...|..|..||:
Mouse   910 ---------------------DASCVSPCVSPTASPRHRH 928

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GABA-B-R2	NP_001287456.1	PBP1_GABAb_receptor	32..418	CDD:107361	159/397 (40%)
		ANF_receptor	52..396	CDD:279440	144/355 (41%)
		7tm_3	459..712	CDD:278433	138/258 (53%)
Gabbr2	NP_001074610.1	PBP1_GABAb_receptor	57..459	CDD:380589	159/404 (39%)
		7tmC_GABA-B-R2	479..748	CDD:320421	142/278 (51%)
		TM helix 1	479..504	CDD:320421	8/24 (33%)
		TM helix 2	516..537	CDD:320421	11/20 (55%)
		TM helix 3	553..577	CDD:320421	14/23 (61%)
		TM helix 4	596..616	CDD:320421	8/19 (42%)
		TM helix 5	652..678	CDD:320421	18/25 (72%)
		TM helix 6	687..710	CDD:320421	15/22 (68%)
		TM helix 7	717..742	CDD:320421	13/24 (54%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	762..789		6/26 (23%)
		GBR2_CC	778..816	CDD:375881	8/37 (22%)
		PRK03992	785..>863	CDD:179699	22/112 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840824
Domainoid	1	1.000	283	1.000	Domainoid score	I1638
eggNOG	1	0.900	-	-		E1_KOG1055
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55902
Inparanoid	1	1.050	592	1.000	Inparanoid score	I976
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005571
OrthoInspector	1	1.000	-	-		oto94978
orthoMCL	1	0.900	-	-		OOG6_102670
Panther	1	1.100	-	-	LDO	PTHR10519
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3137
SonicParanoid	1	1.000	-	-		X5209
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.780