DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GABA-B-R2 and Gpr156

DIOPT Version :9

Sequence 1:	NP_001287456.1	Gene:	GABA-B-R2 / 42561	FlyBaseID:	FBgn0027575	Length:	1224	Species:	Drosophila melanogaster
Sequence 2:	NP_700443.2	Gene:	Gpr156 / 239845	MGIID:	2653880	Length:	798	Species:	Mus musculus

Alignment Length:	871	Identity:	202/871 - (23%)
Similarity:	330/871 - (37%)	Gaps:	239/871 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   420 KPVKWVGKTPPKDRTLIYIEHSQ-----VNPTIYIVSASASVIGVIIATVFLAFNIKYRNQRYIK 479
            :|:..:.||     |:...:||.     ::|.:..:..:....|:::...||||.|:.|..|.:|
Mouse    22 RPLHDLCKT-----TITESQHSSTAASPLSPALLGIMWTFLSCGLLLVLFFLAFTIRCRKNRIVK 81

  Fly   480 MSSPHLNNLIIVGCMMTYLSIIFLGLDTTL--SSVAAFPYICTARAWILMAGFSLSFGAMFSKTW 542
            ||||:||.:.::|..:||:|....|:...|  |||.|   :...|..:|..|.||.||.:..|:|
Mouse    82 MSSPNLNVVTLLGSCLTYISAYLFGIQDALEGSSVEA---LIQTRLSLLCIGTSLVFGPILGKSW 143

  Fly   543 RVHSIFTDLKLNKKV-IKDYQLFMVVGVLLAIDIAIITTWQIADPFYRETKQLEPLHHENI---- 602
            |::.:||....:|:| |||.||..:|..|:..|:.::.||.:.||       ::.|....:
Mouse   144 RLYKVFTQRVPDKRVIIKDLQLLGLVAALVVADVILLVTWVLTDP-------IQCLQMLGVSMKV 201

  Fly   603 ---DDVLVIPENEYCQSEHMTIFVSIIYAYKGLLLVFGAFLAWETRHVSIPALNDSKHIGFSVYN 664
               |....:....:|.|.:..::::::...|||||::||:||..|.|||.|.:|.|..|...|..
Mouse   202 TGRDVSCSLTNTHFCASRYSDVWIALVLGCKGLLLLYGAYLAGLTNHVSSPPVNQSLTIMVGVNL 266

  Fly   665 VFITCLAGAAISLVLSDRKDLVFVLLSFFIIFCTTATLCLVFVPKVRLVLVELKRNPQGVVDKRV 729
            :.:|......::..|....:|||.|.|..|..|||...|.||:|:::          |....:..
Mouse   267 LLLTAGLLFVVTRYLHSWPNLVFGLTSGGIFVCTTTVNCCVFIPQLK----------QWKAFEGE 321

  Fly   730 RATLRPMSK---------NGRRDSS-VCELEQRLRDVKNTNCRFRKALMEKENELQALIRKLGPE 784
            ..|:|.|:|         :|:.|.. .|    .|||.|  :| ..:.|.||...:::|..::
Mouse   322 NQTMRHMAKYFSTPSKSFHGQFDEDPSC----HLRDEK--SC-MERLLTEKNAVIESLQEQV--- 376

  Fly   785 ARKWIDGVTCTGGSNVGSELEPILNDDIVRLSAPPVRREMPSTTVTEMTSVDSVTSTHVEMDNSF 849
                         ||.        .:.:|:|.:.....:.|...|.:..|...:
Mouse   377 -------------SNA--------KEKLVKLMSAECTYDSPEWAVPDAASARGL----------- 409

  Fly   850 VSVQSTVMAPSLPPKKKKQSIVEHHS--------HAPA-------------PTMMQPIQQ----- 888
                      :||...:..::.|:.|        |.||             .|...|.||
Mouse   410 ----------ALPGPSECPAVSENESGAAARDSLHVPAACQHVQGPGASRRDTSPSPAQQDNMPL 464

  Fly   889 -QLQQHL----QQHQQMQQQHLQQQQHQQMQQQQQQ--------QQHHHRHLEKRNSVSAQTDDN 940
             |...||    .|..:.:|....::..|:.....|:        :.|..|          |:.:.
Mouse   465 KQYCDHLDTGCNQKPKAEQSEGPERGDQEPMAPSQRLMADGVACEPHKPR----------QSPEG 519

  Fly   941 IGSITSTAGKRSGGDCSSMRERRQSTASRHYDSGSQTPTARPKYSSSHRNSSTNISTSQSELSNM 1005
            :       .|:..|..|.:||:.|... :..|.||:.|.:..........|:|  |.|..:||
Mouse   520 L-------PKKLPGVSSVVREKLQEVL-QELDLGSEAPLSPLPCPQQLWKSTT--SRSPQKLS-- 572

  Fly  1006 CPHSKPSTPAVIKTPTASDHRRT--------SMGSALKSNFVVSQSDLWDTHTLSHAKQRQSPRN 1062
             |.....:|.|::...|:...|:        ::|....|....|||.|       ..:.|.|||
Mouse   573 -PSKLGFSPYVVRRRRAAQRARSHIPGSVGLNVGHQANSTVSSSQSGL-------IVQNRDSPR- 628

  Fly  1063 YASPQRCAEHHGGHGMTYDPNTTSPIQRSVSEKNRNKHRPKPQKGTVCQSETDSERERDPPPNSQ 1127
                   .:|:         |..|.:.||.|.|......|:.::||:   |...:.|.:|.....
Mouse   629 -------LDHN---------NARSKVPRSSSVKPSPLSEPRRKQGTL---EGSKQCETEPQEAGG 674

  Fly  1128 PCVQPRKVSRSSNIQHAAHHHSSPNVAPDKQRSRQRGKQDSSIYGASSETELLEGETAILPIFRK 1192
            .|                      |||...|.|       :|:...|.....|....| ||
Mouse   675 AC----------------------NVAFPCQSS-------ASVQAQSPAAPCLPSSPA-LP---- 705

  Fly  1193 LLTEKSPNYRGRSAVGQSCPNISIKC 1218
              .::.|    |..:...||::|..|
Mouse   706 --RQRQP----RPRLSPGCPSLSSGC 725

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GABA-B-R2	NP_001287456.1	PBP1_GABAb_receptor	32..418	CDD:107361
		ANF_receptor	52..396	CDD:279440
		7tm_3	459..712	CDD:278433	87/262 (33%)
Gpr156	NP_700443.2	7tm_3	71..>141	CDD:278433	27/72 (38%)
		rad18	347..>538	CDD:273165	44/259 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	441..497		10/55 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	546..666		34/151 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	693..715		6/32 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840825
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1055
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S7921
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10519
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.790