DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GABA-B-R2 and gbb-2

DIOPT Version :9

Sequence 1:	NP_001287456.1	Gene:	GABA-B-R2 / 42561	FlyBaseID:	FBgn0027575	Length:	1224	Species:	Drosophila melanogaster
Sequence 2:	NP_500579.3	Gene:	gbb-2 / 191240	WormBaseID:	WBGene00022675	Length:	842	Species:	Caenorhabditis elegans

Alignment Length:	809	Identity:	306/809 - (37%)
Similarity:	444/809 - (54%)	Gaps:	74/809 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 MPSVKLALGHVNEHGKILANYRLHMWWNDTQCNAAVGVKSFFDMMHSGPNKVMLFGAACTHVTDP 117
            :|:::.||.||:....||..|||.|...||.|..:.|:|:.||::.|.|..|.:.|..||.|.:|
Worm    51 LPAIRTALSHVHSRSCILQGYRLEMIVKDTHCKTSQGMKALFDLIASRPRPVAILGGQCTEVNEP 115

  Fly   118 IAKASKHWHLTQLSYADTHPMF----TKDAFPNFFRVVPSENAFNAPRLALLKEFNWTRVGTVYQ 178
            ||.|.|:|.:.|||||:||..|    :.:.|..||||||.....|..:...:..|.|.|||||.|
Worm   116 IAMALKYWQIVQLSYAETHAKFASSDSHELFTTFFRVVPGSRNTNMAKCKFVNHFGWKRVGTVKQ 180

  Fly   179 N-EPRYSLPHNHMVADLD-AMEVEVVETQSF----VNDVAESLKKLREKDVRIILGNFNEHFARK 237
            | :|||:|||..:...|: ...|::|.|...    :..|...|.:|:|:||||||.:.:|..|..
Worm   181 NDQPRYALPHEALTTRLEHGFGVKIVHTAGVNWEQIETVGGELDELKERDVRIILVDVDEEMAAT 245

  Fly   238 AFCEAYKLDMYGRAYQWLIMATYSTDWWNVTQDSECSVEEIATALEGAILVDLLPLSTSGDITVA 302
            ..|..|...|||..|.|::...:|..|.|.|.|: |:|||:..|.:....|:........|..:.
Worm   246 VLCAGYHRGMYGDNYVWILPGYHSDKWLNQTHDN-CTVEEMREAAKNHFSVEFALTRRDVDTKIV 309

  Fly   303 GIT-ADEYLVEYDRLRGTEYSRFHGYTYDGIWAAALAIQYVAEKREDLLTHFDYRVKDWESVFLE 366
            |.| |.:...|..:|  ...:.:.||.|||:|..|:|:.:......:...|          ..:|
Worm   310 GNTRAGDVWNEITQL--DPNNTWRGYLYDGLWTLAIALSHSMGDNAEFSHH----------KMME 362

  Fly   367 ALRNTSFEGVTGPVRFYNNERKANILINQFQLGQMEKIGEYHSQKSHLDLSLGKPVKWVGKTPPK 431
            |:.|:||:|:||.|:|.||||...:.|.|:..||......|........:.......|   :||.
Worm   363 AIDNSSFQGLTGKVKFANNERLGLVDIKQWSDGQYVPFAVYDGADDEFKIIDSTTKGW---SPPL 424

  Fly   432 DRTLIYIEHSQVNPTIYIVSASASVIGVIIATVFLAFNIKYRNQRYIKMSSPHLNNLIIVGCMMT 496
            |.|:.......::..:::..:..::||:.:|.:||..|.:|||.|:||||||:|||:||.|.:.|
Worm   425 DSTITERRREHISSILFLAMSLLALIGIFLALIFLLINFRYRNHRFIKMSSPNLNNIIIAGSICT 489

  Fly   497 YLSIIFLGLDTTLSSVAAFPYICTARAWILMAGFSLSFGAMFSKTWRVHSIFTDLKLNKKVIKDY 561
            :.|:|.|||||.:.|...|.::|..:.|.|..||:||||||||||||||||||::::::|.|||.
Worm   490 FASVIMLGLDTRIVSPDVFVWLCYTKTWTLCIGFTLSFGAMFSKTWRVHSIFTNIRMDRKAIKDS 554

  Fly   562 QLFMVVGVLLAIDIAIITTWQIADPF-YRETKQLEPLHHENIDDVLVIPENEYCQSEHMTIFVSI 625
            :||:::|:||.|||.::.||....|| |..|:    |.|...|::::|||.|.|.|.|..:|.::
Worm   555 KLFIILGILLFIDICVLVTWAFVSPFSYTVTE----LPHIPEDNIVIIPEVEKCNSSHSGVFQAV 615

  Fly   626 IYAYKGLLLVFGAFLAWETRHVSIPALNDSKHIGFSVYNVFITCLAGAAISLVLSDRKDLVFVLL 690
            :||.||:|::.|.|||||||||::|||||||:||.|||...:..:.|.:.|::|.:|.:.:|.|.
Worm   616 LYAVKGVLMILGCFLAWETRHVNVPALNDSKYIGTSVYCCVVMSVLGLSTSVILQERVNEMFSLA 680

  Fly   691 SFFIIFCTTATLCLVFVPKVRLVLVELKRNP---------QGVVDKRVRATLRPMSKNGRRDSS- 745
            |||:||.||.||||||||||    :||.|||         :|::...|..|.:|||...|.|||
Worm   681 SFFVIFSTTLTLCLVFVPKV----IELARNPVGNEPRAYRRGLMKSVVAKTSQPMSPQPRSDSSG 741

  Fly   746 ----VCELEQRLRDVKNTNCRFRKALMEKENELQALIRKLGPEA------RKWIDGVTCTGGSNV 800
                ..|.|.:||         |:.|.:|..:|..|:.||..:.      ::|     |...::.
Worm   742 DLIGKAESENKLR---------RRYLHQKSTQLWDLVEKLRAQGDTRFLQQEW-----CLSSASP 792

  Fly   801 GS-ELEPILNDDIVRLSAPPVRREMPSTT 828
            .| |.|..|   ::|..:....||..|.|
Worm   793 SSQERETSL---LLRQPSSSNNREETSLT 818

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GABA-B-R2	NP_001287456.1	PBP1_GABAb_receptor	32..418	CDD:107361	130/375 (35%)
		ANF_receptor	52..396	CDD:279440	126/353 (36%)
		7tm_3	459..712	CDD:278433	132/253 (52%)
gbb-2	NP_500579.3	PBP1_GABAb_receptor	50..395	CDD:107361	127/356 (36%)
		7tmC_GABA-B-R2	439..705	CDD:320421	136/273 (50%)
		TM helix 1	439..464	CDD:320421	6/24 (25%)
		TM helix 2	476..497	CDD:320421	10/20 (50%)
		TM helix 3	513..537	CDD:320421	15/23 (65%)
		TM helix 4	556..576	CDD:320421	10/19 (53%)
		TM helix 5	609..635	CDD:320421	12/25 (48%)
		TM helix 6	644..667	CDD:320421	9/22 (41%)
		TM helix 7	674..699	CDD:320421	16/24 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160158267
Domainoid	1	1.000	279	1.000	Domainoid score	I900
eggNOG	1	0.900	-	-		E1_KOG1055
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55902
Inparanoid	1	1.050	520	1.000	Inparanoid score	I685
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D267884at33208
OrthoFinder	1	1.000	-	-		FOG0005571
OrthoInspector	1	1.000	-	-		oto18343
orthoMCL	1	0.900	-	-		OOG6_102670
Panther	1	1.100	-	-	LDO	PTHR10519
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3137
SonicParanoid	1	1.000	-	-		X5209
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.790