DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GABA-B-R2 and gpr156

DIOPT Version :9

Sequence 1:	NP_001287456.1	Gene:	GABA-B-R2 / 42561	FlyBaseID:	FBgn0027575	Length:	1224	Species:	Drosophila melanogaster
Sequence 2:	XP_004919836.1	Gene:	gpr156 / 101730302	XenbaseID:	XB-GENE-962217	Length:	792	Species:	Xenopus tropicalis

Alignment Length:	813	Identity:	180/813 - (22%)
Similarity:	307/813 - (37%)	Gaps:	179/813 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   412 SHLDLSLGK-----------PVKWVGKTPPKDRTLIYIEHSQVNPTIYIVSASASVIGVIIATVF 465
            ||:|..|.|           .|.|..            :..||:..:..:|.:....|:::...|
Frog    13 SHIDTGLEKEEAAKVLQELCKVSWAP------------QRKQVSAAVLGISGALLSAGLLLTLFF 65

  Fly   466 LAFNIKYRNQRYIKMSSPHLNNLIIVGCMMTYLS-IIFLGLDTTLSSVAAFPYICTARAWILMAG 529
            ..|.:::|:.|.:|||||:||.:.::|..:||:| .:|:..:..:|....|    ..|..:|..|
Frog    66 FIFTLRFRSNRIVKMSSPNLNLVTLIGSALTYISAFLFVVQEPNISMETIF----QVRISLLYLG 126

  Fly   530 FSLSFGAMFSKTWRVHSIFTDLKLNKKV-IKDYQLFMVVGVLLAIDIAIITTWQIADPFYRETKQ 593
            .:|.||.:..|:||:|.:||....:|:| |||..|..:|..||..|..::..|.::||.......
Frog   127 VTLVFGPLLGKSWRLHRVFTHRVPDKRVIIKDVTLLSLVAGLLFADTLLLLMWVLSDPVVCARSA 191

  Fly   594 LEPLHHENIDDVLVIPENEYCQSEHMTIFVSIIYAYKGLLLVFGAFLAWETRHVSIPALNDSKHI 658
            ...:.......:..:...::|.|::..::..::..:|..||::|.:||..|.::|.|.:|.|  :
Frog   192 SASIKAAARGTLYSVTTQDFCASKYSDLWTGLLVGFKAALLIYGGYLAGLTNNISSPPVNQS--L 254

  Fly   659 GFSVYNVFITCLAGAA--ISLVLSDRKDLVFVLLSFFIIFCTTATLCLVFVPKVRLVLVELKRNP 721
            ...:.|..:....||.  ::....|..:||:...|..|:.||||..||:|:|:   :|...:...
Frog   255 AIMIGNGLVMAGTGAVFLVTHFFHDWSNLVYATTSGSILVCTTAINCLIFIPQ---LLQSRQFEE 316

  Fly   722 QGVVDKRVRATLRPMSKNGRRDSSVCELEQRLRDVKNTNCRFRKALMEKENELQALIRKLGPEAR 786
            :.|...::.......||:.|...|    |:::..:...|...||.|.||    .|:|..|..:.
Frog   317 EQVQSTQMSKYFSSPSKSFRSMYS----EEQIYHLLGENTSMRKLLSEK----NAIIESLQEQV- 372

  Fly   787 KWIDGVTCTGGSNVGSELEPILNDDIVRLSAPPVRREMPSTTVTEMTSVDSVTSTHVEMDNSFVS 851
                       ||...:|..::..:.             |....|:||:
Frog   373 -----------SNAKEKLMKLIKSEC-------------SFETIEVTSL---------------- 397

  Fly   852 VQSTVMAPSLPPKKKKQSIVEHHSHAPAPTMMQPIQQQLQ-----QH---LQQHQQMQQQH---- 904
              |.:.|.:|        .::||   .||..|:.|::.|.     .|   ::..|::..:|
Frog   398 --SVLSASTL--------AIQHH---VAPEHMKTIEEPLDSVENADHEAVIKDTQEVDIKHDTKS 449

  Fly   905 --LQQQQHQQMQQQQQQQQHHHRHLEKRN--SVSAQTDDNIGSITSTAGKRSGGDCSSMRERRQS 965
              .|..:.|.:|:.:::.|...:...|.:  |||.|.|      .||:..||......:
Frog   450 DAFQSPKDQNIQESEEKPQEGSQCTNKPSGCSVSKQED------MSTSDSRSVSFADIV------ 502

  Fly   966 TASRHYDSGSQTPTARPKYSSSHRN----SSTNISTSQSELS--NMCPHSKPSTPAVIKTPTASD 1024
            :.|.|...|..:...........|.    ||..:.....|||  ..|.|..|..
Frog   503 SKSHHQHPGEASERTHDVLEQLSRKINYVSSEKLQEILQELSIETTCGHHSPKR----------- 556

  Fly  1025 HRRTSMGSALKSNFVVSQSDLWDTHTLS--HAKQRQSPRNYASPQRCAEHHGGHGMTYDPNTTSP 1087
            .||.|.........|.|:.......:||  ..::|:.| .|:...:...||       .||...|
Frog   557 QRRASHSVNRDPGLVPSEGFRKMCVSLSPYMMRRRRGP-VYSQRNQHPSHH-------FPNALPP 613

  Fly  1088 IQRSVSEKN-RNKHRPKPQKGTVCQSETDSERERDPPPNSQPCVQPRKVSRSSNIQHAAHHHSSP 1151
            ....:..|. ||:          |.....:..||..|...:...:       .||.|..|:.|..
Frog   614 QTWCLLNKEARNR----------CNGVKTTRDERPSPTGEERTAE-------GNIGHGHHNPSLL 661

  Fly  1152 NVA-----PDKQRSRQRGKQD---SSIYGASSE 1176
            ..|     |.::.:|.|...|   :..|..:||
Frog   662 TKAMELSVPGREENRSRVDNDIWMTPKYSYASE 694

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GABA-B-R2	NP_001287456.1	PBP1_GABAb_receptor	32..418	CDD:107361	3/5 (60%)
		ANF_receptor	52..396	CDD:279440
		7tm_3	459..712	CDD:278433	72/256 (28%)
gpr156	XP_004919836.1	7tmC_GPR156	71..313	CDD:320419	71/250 (28%)
		TM helix 2	83..104	CDD:320419	7/20 (35%)
		TM helix 3	117..141	CDD:320419	8/23 (35%)
		TM helix 4	161..181	CDD:320419	6/19 (32%)
		TM helix 5	217..243	CDD:320419	6/25 (24%)
		TM helix 6	252..275	CDD:320419	4/24 (17%)
		TM helix 7	282..307	CDD:320419	11/24 (46%)
		PRK07133	<303..>493	CDD:235943	50/260 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10519
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010