DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GABA-B-R2 and LOC100498444

DIOPT Version :9

Sequence 1:	NP_001287456.1	Gene:	GABA-B-R2 / 42561	FlyBaseID:	FBgn0027575	Length:	1224	Species:	Drosophila melanogaster
Sequence 2:	XP_031751053.1	Gene:	LOC100498444 / 100498444	-ID:	-	Length:	1008	Species:	Xenopus tropicalis

Alignment Length:	848	Identity:	164/848 - (19%)
Similarity:	291/848 - (34%)	Gaps:	268/848 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 ALGHVNEHGKILANYRLHMWWNDTQCNAAVGVKSFFDMMHSGPNKVM-------------LFGAA 110
            |:..:|.:..||.|..|.....|:..|....::..|.:: |||.:.:             ..|..
Frog    77 AVDEINRNPAILPNVTLGYHIFDSCRNVNNAMQDVFSIL-SGPGETVPNYSCREQHRVAGFIGDL 140

  Fly   111 CTHVTDPIAKASKHWHLTQLSYADT-HPMFTKDAFPNFFRVVPSENAFNAPRLALLKEFNWTRVG 174
            .|..:.|||:..:.:..:|:||..| |.:..|..:|.|||.:|::.........||:...|..||
Frog   141 FTETSLPIAQLLRPYGYSQISYGATDHLLSDKRFYPAFFRTLPNDQTQYQAIAKLLRHLGWNWVG 205

  Fly   175 TVYQNEPRYSLPHNHMVADLDAMEVEVVETQSFVNDVAESLKKLREKDVRIILGNFNEHFARKAF 239
            .:..::                             |:.|.|    .:|:..:||.:       ..
Frog   206 IIRSDD-----------------------------DIGEQL----SRDLSKVLGEY-------GI 230

  Fly   240 CEAYKL-----------DMYGRAYQWLIMATYSTDWWNVTQDSECSVEEIATALEGAILVDLL-- 291
            |..|.|           ::|.| .|..:..|.|......::.|...:..: |..||::|..:|
Frog   231 CIEYTLSIPEEQNPRRDELYAR-LQGKLRQTTSRGAVMCSRVSLFYMNSL-TREEGSLLEKILIV 293

  Fly   292 -------PLSTS----------------------------------GDITVAGITADEY------ 309
                   |.||:                                  ||..:..|.|..:
Frog   294 PVNWNYRPYSTARSLRTLYNGTLFFKRPSKNLPRLHRLLENLNRTKGDKMLEDIFATYFNCLTSV 358

  Fly   310 -----LVE--YDRLRG--------TEYSRFHGY----------TYDGIWAAALAIQYVAEKREDL 349
                 :::  |..:.|        |:..| .||          .|..::|.|.|:.::...|...
Frog   359 PLRNTMIQTIYPLVLGNCSGKEKITQLKR-KGYNTVTFRTTYHVYKAVYAMAYALHHMLLPRGPP 422

  Fly   350 LTHFDYRVKDWESVFLEALRNTSFEGVTG-PVRFYNNERKANI--LINQFQ----LGQMEKIGEY 407
            ..|....:.  ...|...|....|:..|| .:.|..|...:::  |:.|..    ..::..:|.:
Frog   423 HLHTGAHIH--RERFRHFLTKVHFKDPTGEEIYFKENGEMSSVYHLLQQINWVNGTTELRHVGTF 485

  Fly   408 HSQKS--------------HLDLSLGKPV-KWVGKTPPKDRTLIYIEHSQVNPTIY--------- 448
            :|...              |||.| |.|| :...:.||..|.|  ....|.:...|
Frog   486 NSSAPEEEQLIIAHRGFMWHLDGS-GIPVSRCTPRCPPGQRKL--PRRGQQHACCYDCVQCSEGM 547

  Fly   449 ----------------------------------------------IVSASASVIGVIIATVFLA 467
                                                          |||...|.:..||..:|:|
Frog   548 ISNDTDREACQPCPEDKWPNQKKDQCLPRSSEFLSYQSDWKTLLFSIVSILLSGVTAIIVGIFVA 612

  Fly   468 FNIKYRNQRYIKMSSPHLNNLIIVGCMMTYLSI-IFLG--LDTTLSSVAAFPYICTARAWILMAG 529
            |    |:...:|.::..|:.|::...||::|.: :|||  |..|          |..|...:...
Frog   613 F----RHSPIVKANNQRLSFLLLGSIMMSFLCVFLFLGRPLHVT----------CMLRQTCMGII 663

  Fly   530 FSLSFGAMFSKTWRVHSIFTDLKLNKKVIKDYQLFMVVGVLLA---IDIAIITTWQIADPFYRET 591
            ||:...::.:||..|..:|...|......|.....:..||::|   :.::|...|....|.:.|.
Frog   664 FSVVVSSVLAKTIMVCIVFKASKPGNYWKKCVGAKIPNGVVVACSLLQVSISIAWLSISPPFMEL 728

  Fly   592 KQLEPLHHENIDDVLVIPENEYCQSEHMTIFVSIIYAYKGLLLVFGAFLAWETRHVSIP-ALNDS 655
            .:..|      ..:|:     .|.......|.::: .|.|||......:|:..|  .:| :.|::
Frog   729 NRSFP------GKILI-----QCNEGSPVAFYAVL-GYLGLLAAVSFIVAFLAR--KLPDSFNEA 779

  Fly   656 KHIGFSVY---NVFITCLAGAAISLVLSDRKDLVFVLLSFFIIFCTTATLCLVFVPKVRLVLVEL 717
            |:|.||:.   :|:::.:. |.:|:.   .|:.|.|.: |.|:..:...|..:|.||..::|::.
Frog   780 KYITFSMLVFCSVWVSFIP-AHLSVT---GKNTVVVEI-FAIMASSFGVLASIFFPKCYIILIKP 839

  Fly   718 KRN 720
            ::|
Frog   840 EQN 842

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GABA-B-R2	NP_001287456.1	PBP1_GABAb_receptor	32..418	CDD:107361	86/478 (18%)
		ANF_receptor	52..396	CDD:279440	80/438 (18%)
		7tm_3	459..712	CDD:278433	62/262 (24%)
LOC100498444	XP_031751053.1	Periplasmic_Binding_Protein_type1	34..504	CDD:415822	83/472 (18%)
		NCD3G	512..566	CDD:400103	8/55 (15%)
		7tmC_V2R_pheromone	592..836	CDD:320410	66/276 (24%)
		TM helix 1	592..612	CDD:320410	7/19 (37%)
		TM helix 2	624..645	CDD:320410	5/20 (25%)
		TM helix 3	654..676	CDD:320410	4/21 (19%)
		TM helix 4	702..718	CDD:320410	4/15 (27%)
		TM helix 5	744..767	CDD:320410	5/23 (22%)
		TM helix 6	779..801	CDD:320410	6/22 (27%)
		TM helix 7	806..831	CDD:320410	7/25 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D590810at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010