DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GABA-B-R2 and gabbr1

DIOPT Version :9

Sequence 1:	NP_001287456.1	Gene:	GABA-B-R2 / 42561	FlyBaseID:	FBgn0027575	Length:	1224	Species:	Drosophila melanogaster
Sequence 2:	XP_012823396.1	Gene:	gabbr1 / 100135080	XenbaseID:	XB-GENE-956617	Length:	987	Species:	Xenopus tropicalis

Alignment Length:	786	Identity:	247/786 - (31%)
Similarity:	417/786 - (53%)	Gaps:	49/786 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 TAKRSDVYIAGFFPYGDGVENSYTGRGVMPSVKLALGHVNEHGKILANYRLHMWWNDTQCNAAVG 89
            ::::..:::...||...|...   |:...|:.::||..||....||..|.|.:..:|:||:....
Frog   169 SSRKRALHVGALFPMSGGWPG---GQACQPAAQMALEDVNNRRDILPEYELRLIHHDSQCDPGQA 230

  Fly    90 VKSFFDMMHSGPNKVMLFGAACTHVTDPIAKASKHWHLTQLSYADTHP-MFTKDAFPNFFRVVPS 153
            .:..::::::.|.|:||. ..|:.|:..:|:|::.|||..|||..:.| :..:..||.|||..||
Frog   231 TRYLYELLYNDPIKIMLM-PGCSSVSTLVAEAARMWHLIVLSYGSSSPALSNRQRFPTFFRTHPS 294

  Fly   154 ENAFNAPRLALLKEFNWTRVGTVYQNEPRYSLPHNHMVADLDAME-------VEVVETQSFVNDV 211
            ....|..|:.|.|::.||::.|:.|....::       :.||.:|       :|:...|||.:|.
Frog   295 ATLHNPTRVQLFKKWGWTKIATIQQTTEVFT-------STLDDLEERVKEAGIEITFRQSFFSDP 352

  Fly   212 AESLKKLREKDVRIILGNFNEHFARKAFCEAYKLDMYGRAYQWLIMATYSTDWWNVTQDS-ECSV 275
            |..:|.|:.:|.|:|:|.|.|..|||.|||.||..::|:.|.|.::..|:.:|:.:...: .|:|
Frog   353 AIPVKNLKRQDARVIVGLFYETEARKVFCEVYKERLFGKKYVWFLIGWYADNWFKIPDPAINCTV 417

  Fly   276 EEIATALEGAILVDLLPLSTSGDITVAGITADEYLVEYDRLRGTEYSRFHG-----YTYDGIWAA 335
            ||:..|:||.:..:::.|:......::.:|:.|::.:..:..|.......|     ..||.|||.
Frog   418 EEMTQAVEGHVTTEIVMLNPENTRGISNMTSQEFMEKLKKRLGENPEMTGGLQEAPLAYDAIWAL 482

  Fly   336 ALAIQ---YVAEKREDLLTHFDYRVKDWESVFLEALRNTSFEGVTGPVRF-YNNERKANILINQF 396
            |||:.   |...|:...|..|:|..|........|:.::||:||:|.|.| .:..|.|..||.|.
Frog   483 ALALNKTAYELSKKGRRLEDFNYNNKMISEEIYRAMNSSSFDGVSGHVVFDASGSRMAWTLIEQL 547

  Fly   397 QLGQMEKIGEYHSQKSHLDLSLGKPVKWVGKTPPKDRTLIYIEHSQVNPTIYIVSASASVIGVII 461
            |.|..:|||.|.|.|.  :||.....||:|.:||.|.|.:.|....|:..::|..:..:.:|:::
Frog   548 QGGVYKKIGYYDSTKD--NLSWYNNDKWIGGSPPADHTKVIITFRYVSQKLFISVSVLAGLGILL 610

  Fly   462 ATVFLAFNIKYRNQRYIKMSSPHLNNLIIVGCMMTYLSIIFLGLDTTLSSVAAFPYICTARAWIL 526
            ..|.|:|||...:.|||:.|.||||::...||:::..::..||||........||.:|.||.|:|
Frog   611 GFVCLSFNIYNSHVRYIQNSQPHLNDVTAAGCILSLAAVFPLGLDGRHIETWHFPLVCQARLWLL 675

  Fly   527 MAGFSLSFGAMFSKTWRVHSIFT---DLKLNKK---VIKDYQLFMVVGVLLAIDIAIITTWQIAD 585
            ..||||::|:||:|.|.:|:.||   |.|..:|   .::.::|:..|.:||.:|:..:..|||.|
Frog   676 GLGFSLAYGSMFTKIWWIHTAFTKKDDKKERRKQSQTLEPWKLYTTVSLLLGLDVITLGIWQIVD 740

  Fly   586 PFYRETKQLEPLHHENIDDVLVIPENEYCQSEHMTIFVSIIYAYKGLLLVFGAFLAWETRHVSIP 650
            |..|..::..........|||::|:.|:|.|..|..::.|:|..|||||:.|.|||:||:.||..
Frog   741 PLQRSIEEFTKEEPRGDLDVLILPQLEHCSSLKMNTWLGIVYGSKGLLLLLGIFLAYETKSVSTE 805

  Fly   651 ALNDSKHIGFSVYNVFITCLAGAAISLVLSDRKDLVFVLLSFFIIFCTTATLCLVFVPKVRLVLV 715
            .:||.:.:|.::|||.:.||..|.::::||.::|..|...|..|:|....||.::||||:|.::.
Frog   806 KINDHRAVGMAIYNVAVLCLITAPVTMILSSQQDASFAFSSLAIVFSAYITLVVLFVPKMRRLIT 870

  Fly   716 ELKRNPQGVVDKRVRATLRPMSKNGRRDSSVCELEQRLRDVKNTNCRFRKALMEKENELQALIRK 780
                  :|......:.||:..|.....:      |::.|.::..|....:.:.|||..:..|.::
Frog   871 ------RGEWQSEQQDTLKTGSSTNNNE------EEKSRLLERENQELGRIIAEKEERVMELRQQ 923

  Fly   781 LGPEAR 786
            |....|
Frog   924 LRSRRR 929

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GABA-B-R2	NP_001287456.1	PBP1_GABAb_receptor	32..418	CDD:107361	124/403 (31%)
		ANF_receptor	52..396	CDD:279440	110/361 (30%)
		7tm_3	459..712	CDD:278433	97/258 (38%)
gabbr1	XP_012823396.1	CCP	104..156	CDD:153056
		PBP1_GABAb_receptor	176..575	CDD:380589	127/411 (31%)
		7tmC_GABA-B-R1	595..870	CDD:320418	100/274 (36%)
		TM helix 1	595..620	CDD:320418	6/24 (25%)
		TM helix 2	632..653	CDD:320418	6/20 (30%)
		TM helix 3	669..693	CDD:320418	13/23 (57%)
		TM helix 4	718..738	CDD:320418	6/19 (32%)
		TM helix 5	774..800	CDD:320418	13/25 (52%)
		TM helix 6	809..832	CDD:320418	8/22 (36%)
		TM helix 7	839..864	CDD:320418	9/24 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D267884at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920