DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Burs and CRIM1

DIOPT Version :9

Sequence 1:	NP_650983.1	Gene:	Burs / 42560	FlyBaseID:	FBgn0038901	Length:	173	Species:	Drosophila melanogaster
Sequence 2:	XP_011531200.1	Gene:	CRIM1 / 51232	HGNCID:	2359	Length:	1077	Species:	Homo sapiens

Alignment Length:	166	Identity:	34/166 - (20%)
Similarity:	55/166 - (33%)	Gaps:	54/166 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 YCVLVSILKLCTAQPDSSVAATDNDITHLGDDCQV--TPVIHVLQYPGCVPKPIPSFACVGR-CA 81
            :||.....:.||           |.:...|:.|.|  .|.|..:..|.|  ..:.:....|: |
Human   473 HCVATVCGQTCT-----------NPVKVPGECCPVCEEPTIITVDPPAC--GELSNCTLTGKDC- 523

  Fly    82 SYIQVSGSKIWQMERSCMCCQ------ESGEREAAVSLFCP-------------KVKPGERKFKK 127
                ::|.|  :....|..||      ...||:...:|.||             :.:|..:|.:.
Human   524 ----INGFK--RDHNGCRTCQCINTEELCSERKQGCTLNCPFGFLTDAQNCEICECRPRPKKCRP 582

  Fly   128 VLTK--APLE----------CMCRPCTSIEESGIIP 151
            ::..  .||.          |.|:.|..:..|.|.|
Human   583 IICDKYCPLGLLKNKHGCDICRCKKCPELSCSKICP 618

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Burs	NP_650983.1	GHB_like	50..138	CDD:419725	23/121 (19%)
CRIM1	XP_011531200.1	IGFBP	39..90	CDD:278641
		VWC	377..431	CDD:214564
		VWC	444..497	CDD:214564	7/34 (21%)
		Antistasin	608..633	CDD:280912	4/11 (36%)
		VWC	653..703	CDD:302663
		VWC	724..775	CDD:302663
		VWC	799..849	CDD:214564
		VWC	860..914	CDD:302663
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1216
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900