DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Burs and VWCE

DIOPT Version :9

Sequence 1:	NP_650983.1	Gene:	Burs / 42560	FlyBaseID:	FBgn0038901	Length:	173	Species:	Drosophila melanogaster
Sequence 2:	NP_689931.2	Gene:	VWCE / 220001	HGNCID:	26487	Length:	955	Species:	Homo sapiens

Alignment Length:	187	Identity:	41/187 - (21%)
Similarity:	58/187 - (31%)	Gaps:	62/187 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 KLCTAQPDSSVAATDNDITHLGDDCQVTPVIHVLQYPG-CVPKPIPSFACVGR------------ 79
            :||..|.|.||:....|..   |.|.     |.::.|| |.|.........||
Human   590 ELCICQADGSVSCKRTDCV---DSCP-----HPIRIPGQCCPDCSAGCTYTGRIFYNNETFPSVL 646

  Fly    80 --CASYIQVSGSKI-------------WQMERSC--MC--CQESGEREAAVSLFCPKVKP----- 120
              |.|.|.:.||..             :..:..|  :|  |...|.:.|...:|....:|
Human   647 DPCLSCICLLGSVACSPVDCPITCTYPFHPDGECCPVCRDCNYEGRKVANGQVFTLDDEPCTRCT 711

  Fly   121 ---GERKFKKVLTK--------APLECMCRPCTSI-----EESGIIPQEIAGYSDEG 161
               ||...:||..:        .|.:| |..|...     |:.|:.|.....:|..|
Human   712 CQLGEVSCEKVPCQRACADPALLPGDC-CSSCPDSLSPLEEKQGLSPHGNVAFSKAG 767

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Burs	NP_650983.1	GHB_like	50..138	CDD:419725	27/135 (20%)
VWCE	NP_689931.2	EGF_CA	142..180	CDD:214542
		cEGF	200..223	CDD:315355
		EGF_CA	220..262	CDD:214542
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	292..329
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	360..380
		VWC	386..440	CDD:327433
		VWC	501..559	CDD:327433
		VWC	572..625	CDD:214564	14/42 (33%)
		VWC	629..684	CDD:327433	8/54 (15%)
		VWC	687..742	CDD:327433	12/55 (22%)
		Atrophin-1	<726..944	CDD:331285	9/43 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	812..889
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	903..955
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1216
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900