Protein Alignment CG42335 and AAP1

DIOPT Version :10

• Sequence 1: NP_732655.3
• Gene: CG42335 / 42558
• FlyBaseID: FBgn0259237
• Length: 924
• Species: Drosophila melanogaster
• Sequence 2: NP_011913.1
• Gene: AAP1 / 856443
• SGDID: S000001089
• Length: 856
• Species: Saccharomyces cerevisiae
• Alignment Length: 954
• Identity: 211/954 - (22%)
• Similarity: 388/954 - (40%)
• Gaps: 191/954 - (20%)

  Fly    27 LEGSVVPSHYNLTIGVLRNSVEPTI----FDGEVSITLRV----VGTLEVQ--QIILHADTLDIT 81
            |..:|.|.||::|:       ||..    |:|.:.|.|::    :.::::.  :|..|:..::
Yeast     6 LPNNVTPLHYDITL-------EPNFRAFTFEGSLKIDLQINDHSINSVQINYLEIDFHSARIE-- 61

  Fly    82 ECWLLDAAGAQVEAIDISR--------LIYEAATQQVRVPLTEAAQPGKNYTLGFKYTGHIRTDM 138
                      .|.||::::        |::...|.:         ..|.:..|...::|.:...|
Yeast    62 ----------GVNAIEVNKNENQQKATLVFPNGTFE---------NLGPSAKLEIIFSGILNDQM 107

  Fly   139 AGFFSASYVERDTNVTRWLALTQMQRINARLVLPCFDEPALKAQFQLQIVRPNGYQSIANTKLKE 203
            |||:.|.|.::.|..|:::|.|||:..:||...||||||.|||.|.:.:|..:....::|..::
Yeast   108 AGFYRAKYTDKVTGETKYMATTQMEATDARRAFPCFDEPNLKATFAVTLVSESFLTHLSNMDVR- 171

  Fly   204 TKALSQDRFVDHFKETPVMSTYLLAFMVAN---------------YSARGNESEFAVLTRPEFYD 253
            .:.:.:.:....|..||.|||||:||:||:               ||..|:| :|.
Yeast   172 NETIKEGKKYTTFNTTPKMSTYLVAFIVADLRYVESNNFRIPVRVYSTPGDE-KFG--------- 226

  Fly   254 NTEFSYHVGQQVVSAYGELFQSPYAELGNDVLQYASSPRFPHNGMENWGLIIYS-DDVLIQEPGY 317
              :|:.::..:.:..:.:.|...|.....|::   :...|....||||||:.|. .|:|:.....
Yeast   227 --QFAANLAARTLRFFEDTFNIEYPLPKMDMV---AVHEFSAGAMENWGLVTYRVIDLLLDIENS 286

  Fly   318 SDDWSDKEFAIRIIAHETSHMWFGDSVTFSWWSYFWLNEAFARYYEYFMAHQLYPDYHLDEQFVV 382
            |.|...:  ...:|.||.:|.|||:.||..||...||||.||.:..::..::..|::.:.||:|.
Yeast   287 SLDRIQR--VAEVIQHELAHQWFGNLVTMDWWEGLWLNEGFATWMSWYSCNKFQPEWKVWEQYVT 349

  Fly   383 RQMQLIFGTDAQNGTQPMTSPESEIQTPSQIAYKFSGIAYAKGACIVRMWRNLMGAENFDTAIRS 447
            ..:|.....|:...:.|:..|.:.....:||   |..|:|:||:.::||....:|.|.|...:..
Yeast   350 DNLQRALNLDSLRSSHPIEVPVNNADEINQI---FDAISYSKGSSLLRMISKWLGEETFIKGVSQ 411

  Fly   448 YLQQYHLTNTVPYNLFYHLFEHWPKNQDV---DLVDFLTDYTEQVGYPMIIVKALQGNKVVTVEQ 509
            ||.::...|....:|       |....|.   |:...:..:|::||:|::.||. ..|| :|:.|
Yeast   412 YLNKFKYGNAKTGDL-------WDALADASGKDVCSVMNIWTKRVGFPVLSVKE-HKNK-ITLTQ 467

  Fly   510 SRFLLNKD--DGSNATLKYTVPITFTTNLERDFYNLTPYKYLHKTVNVLWLDFTSPIDWILFNLR 572
            .|:|...|  :..:.|: |.:.:....:...|              |.|.|:..|    ..|.|:
Yeast   468 HRYLSTGDVKEEEDTTI-YPILLALKDSTGID--------------NTLVLNEKS----ATFELK 513

  Fly   573 QSNYQRVFYDDTLREGLLLAISATNHSG------------IPVENRAQIIDDLFNFAQAQYVDYA 625
            ...:.::..|.:       .|..|::|.            :.||:|..::.|....:.:.|....
Yeast   514 NEEFFKINGDQS-------GIFITSYSDERWAKLSKQANLLSVEDRVGLVADAKALSASGYTSTT 571

  Fly   626 DVFRFLEYLAKEVEYVPWYAVYENLNTVAKR--LTPEQ----LPDFRIYLSSITAAVFEKLG-VG 683
            :....:.....|..:|.|..:..:|:.:...  ..||.    |..|.:.|      |..||. :|
Yeast   572 NFLNLISNWKNEDSFVVWEQIINSLSALKSTWVFEPEDILNALDKFTLDL------VLNKLSELG 630

  Fly   684 WNAQDTPLDVANRNKLIKWLCRYQASN-----CRPKVNVQFVTGHE--VPSPDYRETFYCAASGA 741
            ||..:.......|.|:..:.....:.|     ...::..::..|::  :|:......|...|...
Yeast   631 WNIGEDDSFAIQRLKVTLFSAACTSGNEKMQSIAVEMFEEYANGNKQAIPALFKAVVFNTVARLG 695

  Fly   742 DYNSYTMLWGQYYLENRTSEKNMLWAAISCTRDYETHYHKM--IISGT----------ESVEQKK 794
            ..|:|..::..|.....:.||.:...|:....|.|.....:  ::.||          :.:...|
Yeast   696 GENNYEKIFNIYQNPVSSEEKIIALRALGRFEDKELLERTLSYLLDGTVLNQDFYIPMQGIRVHK 760

  Fly   795 IGIARMYEENPDLVQAIFEMITENIMELAYNFQSWSD------TAEVINDMAEYFTTREQQQLLK 853
            .||.|::           ..:.|:..|:|...|..|.      |..:.|     ||:.|..:.:.
Yeast   761 KGIERLW-----------AWMQEHWDEIAKRLQPGSPVLGGVLTLGLTN-----FTSFEALEKIS 809

  Fly   854 EFYYSNHQFFGESEELLSKSLVTVEKNLNWAETHLEGLVKYLAD 897
            .||  :.:.....::.|:::|.|:.....|.....|.:..||.:
Yeast   810 AFY--SRKVTKGFDQTLAQALDTIRSKAQWVSRDREIVATYLRE 851

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42335	NP_732655.3	M1_APN-Q_like	34..487	CDD:341064	122/489 (25%)
		ERAP1_C	566..878	CDD:463368	62/355 (17%)
AAP1	NP_011913.1	M1_APN-Q_like	13..447	CDD:341064	122/489 (25%)
		ERAP1_C	517..833	CDD:463368	60/346 (17%)