DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42335 and APM1

DIOPT Version :9

Sequence 1:	NP_732655.3	Gene:	CG42335 / 42558	FlyBaseID:	FBgn0259237	Length:	924	Species:	Drosophila melanogaster
Sequence 2:	NP_195035.2	Gene:	APM1 / 829446	AraportID:	AT4G33090	Length:	879	Species:	Arabidopsis thaliana

Alignment Length:	951	Identity:	228/951 - (23%)
Similarity:	403/951 - (42%)	Gaps:	162/951 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 RLEGSVVPSHYNLTIGVLRNSVEPTIFDGEVSITLRVVGTLEVQQIILHADTLDITECWLLDAAG 90
            ||....||..|:|.   |...:....|.|.|:|.|.:|.  :.:.|:|:|..|.:.:..:.....
plant     9 RLPKFAVPKRYDLR---LNPDLIACTFTGTVAIDLDIVA--DTRFIVLNAADLSVNDASVSFTPP 68

  Fly    91 AQVEAIDISRLIYEAATQQVRVPLTEAAQPGKN-YTLGFKYTGHIRTDMAGFFSASYVERDTNVT 154
            :..:|:...:::.....:.:.:...|....|.. ..|||  .|.:...|.||:.::|  ......
plant    69 SSSKALAAPKVVLFEEDEILVLEFGEILPHGVGVLKLGF--NGVLNDKMKGFYRSTY--EHNGEK 129

  Fly   155 RWLALTQMQRINARLVLPCFDEPALKAQFQLQIVRPNGYQSIANTKLKETKALSQDRFVDHFKET 219
            :.:|:||.:..:||...||:||||.||.|::.:..|....:::|..:.|.|.....:.|. ::|:
plant   130 KNMAVTQFEPADARRCFPCWDEPACKATFKITLEVPTDLVALSNMPIMEEKVNGNLKIVS-YQES 193

  Fly   220 PVMSTYLLAFMVANYSARGNESEFAVLTRPEFY------DNTEFSYHVGQQVVSAYGELFQSPYA 278
            |:|||||:|.:|..:....:.:...:..|  .|      |..:|:.|||.:.:..:.|.|..||.
plant   194 PIMSTYLVAIVVGLFDYVEDHTSDGIKVR--VYCQVGKADQGKFALHVGAKTLDLFKEYFAVPYP 256

  Fly   279 ELGNDVLQYASSPRFPHNGMENWGLIIYSDDVLIQEPGYSDDWSDKEFAIRIIAHETSHMWFGDS 343
            ....|::   :.|.|....|||:||:.|.:..|:.:..:|.. |:|:....::|||.:|.|||:.
plant   257 LPKMDMI---AIPDFAAGAMENYGLVTYRETALLYDEQHSAA-SNKQRVATVVAHELAHQWFGNL 317

  Fly   344 VTFSWWSYFWLNEAFARYYEYFMAHQLYPDYHLDEQFVVRQMQLIFGTDAQNGTQPMTSPESEIQ 408
            ||..||::.||||.||.:..|.....|:|::.:..||:....:.: ..|....:.|:   |.|:.
plant   318 VTMEWWTHLWLNEGFATWVSYLATDSLFPEWKIWTQFLDESTEGL-RLDGLEESHPI---EVEVN 378

  Fly   409 TPSQIAYKFSGIAYAKGACIVRMWRNLMGAENFDTAIRSYLQQYHLTNTVPYNLFYHLFEHW--- 470
            ..::|...|..|:|.|||.::||.::.:|||.|..::.:|::.:..:|....:|       |
plant   379 HAAEIDEIFDAISYRKGASVIRMLQSYLGAEVFQKSLAAYIKNHAYSNAKTEDL-------WAAL 436

  Fly   471 ------PKNQDVDLVDFLTDYTEQVGYPMIIVKALQGNKVVTVEQSRFLLNKDDGSNATLKYTVP 529
                  |.|:      .::.:|:|.|||::..|...|.  :.:||||||   ..||....::.||
plant   437 EAGSGEPVNK------LMSSWTKQKGYPVVSAKIKDGK--LELEQSRFL---SSGSPGEGQWIVP 490

  Fly   530 IT-----------FTTNLERDFYNLTPYKYLHKTVNVLWLDFTSPID----WILFNLRQSNYQRV 579
            :|           |....:...|:      |.:.:.....|.:..|:    ||..|:.|:.:.||
plant   491 VTLCCGSYEKRKNFLLESKSGAYD------LKELLGCSIADGSDKINGTCSWIKINVDQAGFYRV 549

  Fly   580 FYDDTLREGLLLAISATNHSGIPVENRAQIIDDLFNFAQAQYVDYADVFRFLEYLAKEVEYVPWY 644
            .|||:|..||.   :||....:...:|..|:||.|....|:....|.:........||::    |
plant   550 KYDDSLAAGLR---NATESQSLTSIDRYGILDDSFALTMARQQSLASLLTLCSAYKKELD----Y 607

  Fly   645 AVYENLNTVAKRL-------TPEQLPDFRIYLSSITAAVFEKLGVGWNAQ--DTPLDVANRNKLI 700
            .|..||..::.::       ..|.:...:.:...:......||  ||:.:  ::.||...|.:::
plant   608 TVLSNLIAISYKVVKIGADANQELMSGIKHFFIGVFQFAAGKL--GWDPKQGESHLDAMLRGEVL 670

  Fly   701 KWLC-------------RYQASNCRPKVNVQFVTGHEVP--SPDYRETFYCA----ASGADYNSY 746
            ..|.             |:.|          |:.....|  .||.|...|.|    |:.:|.:.|
plant   671 TALAVFGHDETLKEAVRRFDA----------FLADRNTPLLPPDIRRAAYVAVMQRANKSDKSGY 725

  Fly   747 TMLWGQYYLENRTSEKNMLWAAISCTRD--YETHYHKMIISGTESVEQKKIGIARMYEENPDL-- 807
            ..|...|...:.:.||..:..:::...|  ........::|.....:....|::.:..|..::
plant   726 ESLLRVYRETDLSQEKTRILGSLASCPDPTIVQDVLNFVLSDEVRNQDALYGLSGVSWEGREVAW 790

  Fly   808 --VQAIFE----------MITENIMELAYNFQSWSDTAEVINDMAEYFTTREQQQLLKEFYYSNH 860
              :|..:|          :||..|..:...|.|:....||    .|:|.||.:..:.:
plant   791 KWLQEKWEYIGNTWGSGFLITRFISAVVSPFASFEKAKEV----EEFFATRSKPSMAR------- 844

  Fly   861 QFFGESEELLSKSLVTVEKNLNWAET-----HLEGLVKYLA 896
                    .|.:|:..|..|.||.|:     :|..||..|:
plant   845 --------TLKQSIERVHINANWVESIKKEDNLTQLVAQLS 877

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42335	NP_732655.3	Peptidase_M1	26..425	CDD:279741	110/405 (27%)
		M1_APN_2	34..492	CDD:189008	124/473 (26%)
		ERAP1_C	567..874	CDD:288671	69/350 (20%)
APM1	NP_195035.2	M1_APN-Q_like	18..453	CDD:341064	121/467 (26%)
APM1	NP_195035.2	ERAP1_C	536..855	CDD:403137	72/356 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	6.020