Protein Alignment CG42335 and Anpep

DIOPT Version :10

• Sequence 1: NP_732655.3
• Gene: CG42335 / 42558
• FlyBaseID: FBgn0259237
• Length: 924
• Species: Drosophila melanogaster
• Sequence 2: NP_112274.1
• Gene: Anpep / 81641
• RGDID: 2991
• Length: 965
• Species: Rattus norvegicus
• Alignment Length: 967
• Identity: 259/967 - (26%)
• Similarity: 425/967 - (43%)
• Gaps: 149/967 - (15%)

  Fly    20 TNAA--------DYRLEGSVVPSHYNLTIGVLRNSVEPT-----IFDGEVSITLRVVGTLEVQQI 71
            ||.|        .|||..:::|..|.:|   ||..:.|.     ||.|  |.|:|.........|
  Rat    61 TNPAIDESKPWNQYRLPKTLIPDSYQVT---LRPYLTPNEQGLYIFKG--SSTVRFTCNETTNVI 120

  Fly    72 ILHADTLDITECW----LLDAAG-AQVEAIDISRLIYEAATQQVRVPLTEAAQPGKNYTLGFKYT 131
            |:|:..|:.|...    .|.|.| .....||.:.|:  ..|:.:.|.|..:...|..|.:..::.
  Rat   121 IIHSKKLNYTNKGNHRVALRALGDTPAPNIDTTELV--ERTEYLVVHLQGSLVKGHQYEMDSEFQ 183

  Fly   132 GHIRTDMAGFFSASYVERDTNVTRWLALTQMQRINARLVLPCFDEPALKAQFQLQIVRPNGYQSI 196
            |.:..|:|||:.:.|:|....  :.:|.||||..:||...|||||||:||.|.:.::.||...::
  Rat   184 GELADDLAGFYRSEYMEGGNK--KVVATTQMQAADARKSFPCFDEPAMKASFNITLIHPNNLTAL 246

  Fly   197 ANTKLKETKALSQDRF--VDHFKETPVMSTYLLAFMVANY----SARGNESEFAVLTRPEFYD-- 253
            :|...|:::.|.:|..  |..|..||.|||||||::|:.:    :...|..:..:..||...|
  Rat   247 SNMLPKDSRTLQEDPSWNVTEFHPTPKMSTYLLAYIVSEFKYVEAVSPNRVQIRIWARPSAIDEG 311

  Fly   254 NTEFSYHVGQQVVSAYGELFQSPYAELGNDVLQYASSPRFPHNGMENWGLIIYSDDVLIQEPGYS 318
            :.:::..|...:::.:.:.:.:.|....:|.:   :.|.|....||||||:.|.:..|:.:| .|
  Rat   312 HGDYALQVTGPILNFFAQHYNTAYPLEKSDQI---ALPDFNAGAMENWGLVTYRESALVFDP-QS 372

  Fly   319 DDWSDKEFAIRIIAHETSHMWFGDSVTFSWWSYFWLNEAFARYYEYFMAHQLYPDYHLDEQFVVR 383
            ...|:||..:.:||||.:|.|||:.||..||:..||||.||.|.|:..|....|.::|.:..|:.
  Rat   373 SSISNKERVVTVIAHELAHQWFGNLVTVDWWNDLWLNEGFASYVEFLGADYAEPTWNLKDLIVLN 437

  Fly   384 QMQLIFGTDAQNGTQPMTSPESEIQTPSQIAYKFSGIAYAKGACIVRMWRNLMGAENFDTAIRSY 448
            .:..:...||...:.|::||.:|:.||:||:..|..|.|:|||.::||..:.:..:.|...:.||
  Rat   438 DVYRVMAVDALASSHPLSSPANEVNTPAQISELFDSITYSKGASVLRMLSSFLTEDLFKKGLSSY 502

  Fly   449 LQQYHLTNTVPYNLFYHLFEHWPKNQDVDL---VDFLTD-YTEQVGYPMIIVKALQGNKVVTVEQ 509
            |..:..:||:..:|:.||.:.......:.|   |..:.| :..|:|:|:|.|....|.    :.|
  Rat   503 LHTFQYSNTIYLDLWEHLQQAVDSQTAIKLPASVSTIMDRWILQMGFPVITVNTSTGE----IYQ 563

  Fly   510 SRFLLNKDD----GSNATLKYTVPITFTTNLERDFYNLTPYKYLHKTVNVLWLDF---------T 561
            ..|||:...    .|:....:.|||.:..|.:.|.|               ||:.         |
  Rat   564 EHFLLDPTSKPTRPSDFNYLWIVPIPYLKNGKEDHY---------------WLETEKNQSAEFQT 613

  Fly   562 SPIDWILFNLRQSNYQRVFYDDT----LREGLLLAISATNHSGIPVENRAQIIDDLFNFAQAQYV 622
            |..:|:|.|:..:.|.:|.||:.    ::..|     .|:.|.|||.||||||.|.||.|.|..:
  Rat   614 SSNEWLLLNINVTGYYQVNYDENNWRKIQNQL-----QTDLSVIPVINRAQIIHDSFNLASAGKL 673

  Fly   623 DYADVFRFLEYLAKEVEYVPWYAVYENLNTVAKRLTPEQL--PDFRIYLSSITA--AVFEKLGVG 683
            ..........:||.|.||:||.|...:||.........::  |..|.....:|.  |.|:.....
  Rat   674 SITLPLSNTLFLASETEYMPWEAALSSLNYFKLMFDRSEVYGPMKRYLKKQVTPLFAYFKIKTNN 738

  Fly   684 W-NAQDTPLDVANRNKLIKWLCRYQASNCRPKVNVQFVTG----------HEVPSPDYRETFYC- 736
            | :...|.::..|....|...|......||     ..|.|          :....|:.|.|.||
  Rat   739 WLDRPPTLMEQYNEINAISTACSSGLEECR-----DLVVGLYSQWMNNSDNNPIHPNLRSTVYCN 798

  Fly   737 -AASGADYNSYTMLWGQYYLENRTSEKNMLWAAISCTRDYETHYHKMIISGTESVEQKKIGIARM 800
             .|.|.: ..:...|.|:......:|.:.|.:|::|:.:.      .|::...|
  Rat   799 AIAFGGE-EEWNFAWEQFRKATLVNEADKLRSALACSNEV------WILNRYLS----------- 845

  Fly   801 YEENPDLVQAIFEMITENIMELAYNF-----------QSWS-----------DTAEVINDMAEYF 843
            |..|||.::.  :..|..|:.:|.|.           .:|.           ..|.:|..:...|
  Rat   846 YTLNPDYIRK--QDATSTIVSIANNVVGQTLVWDFVRSNWKKLFEDYGGGSFSFANLIQGVTRRF 908

  Fly   844 TTREQQQLLKEFYYSNHQF-FGESEELLSKSLVTVEKNLNWAETHLEGLVKYLADRN 899
            ::..:.|.|::|...|... ||.....|.::|...:.|:.|.:.:.:.::|:..:.:
  Rat   909 SSEFELQQLEQFKEDNSATGFGSGTRALEQALEKTKANIKWVKENKDVVLKWFTENS 965

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42335	NP_732655.3	M1_APN-Q_like	34..487	CDD:341064	145/474 (31%)
		ERAP1_C	566..878	CDD:463368	83/355 (23%)
Anpep	NP_112274.1	Cytosolic Ser/Thr-rich junction	33..68		3/6 (50%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	44..68		3/6 (50%)
		Metalloprotease	69..965		256/957 (27%)
		M1_APN-Q_like	84..545	CDD:341064	145/473 (31%)
		ERAP1_C	618..945	CDD:463368	83/356 (23%)