DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42335 and Erap1

DIOPT Version :9

Sequence 1:	NP_732655.3	Gene:	CG42335 / 42558	FlyBaseID:	FBgn0259237	Length:	924	Species:	Drosophila melanogaster
Sequence 2:	NP_109636.1	Gene:	Erap1 / 80898	MGIID:	1933403	Length:	930	Species:	Mus musculus

Alignment Length:	933	Identity:	230/933 - (24%)
Similarity:	413/933 - (44%)	Gaps:	115/933 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 RLEGSVVPSHYNLTIGVLRNSVEPTIFDGEVSITLRVVGTLEVQQIILHADTLDITECWLLDAAG 90
            ||...:.|.||:|   ::..::....|.|:..:  .::.:.....||:|:..|.|::..|...||
Mouse    42 RLPEYMTPIHYDL---MIHANLSTLTFWGKTEV--EIIASRPTSTIIMHSHHLQISKATLRRGAG 101

  Fly    91 AQVEAIDISRLIYEAATQQVRVPLTEAAQP---GKNYTLGFKYTGHIRTDMAGFFSASYVERDTN 152
            ..:....:..|.|.|..|...:    ||||   |..||:...|..::.....||:.::|..::..
Mouse   102 EMLSEEPLKVLEYPAHEQVALL----AAQPLLAGSLYTVIIDYAANLSESFHGFYKSTYRTQEGE 162

  Fly   153 VTRWLALTQMQRINARLVLPCFDEPALKAQFQLQIVRPNGYQSIANTKLKETKALSQDRFVDHFK 217
            : |.||.||.:...||:..||||||||||.|.::|.|...:.:|:|..|.::..:::....|||.
Mouse   163 M-RILAATQFEPTAARMAFPCFDEPALKASFSIKIKRDPRHLAISNMPLVKSVNVAEGLIEDHFD 226

  Fly   218 ETPVMSTYLLAFMVANYSARGNES----EFAVLTRPEFYDNTEFSYHVGQQVVSAYGELFQSPYA 278
            .|..|||||:||:::::.:....:    :.:|...|:..:..:::......::..|.:.|..||.
Mouse   227 ITVKMSTYLVAFIISDFKSVSKMTKSGVKVSVYAVPDKINQADYALDAAVTLLEFYEDYFNIPYP 291

  Fly   279 ELGNDVLQYASSPRFPHNGMENWGLIIYSDDVLIQEPGYSDDWSDKEFAIRIIAHETSHMWFGDS 343
            ....|:   |:.|.|....||||||..|.:..|:.:...|.. |.|.....|::||.:|.|||:.
Mouse   292 LPKQDL---AAIPDFQSGAMENWGLTTYRESSLLYDKEKSSA-SSKLGITMIVSHELAHQWFGNL 352

  Fly   344 VTFSWWSYFWLNEAFARYYEYFMAHQLYPDYHLDEQFVVRQMQLIFG-------TDAQNGTQPMT 401
            ||..||:..||||.||::.|:......:|:..:::.|        ||       .||.|.:.|::
Mouse   353 VTMEWWNDLWLNEGFAKFMEFVSVTVTHPELKVEDYF--------FGKCFNAMEVDALNSSHPVS 409

  Fly   402 SPESEIQTPSQIAYKFSGIAYAKGACIVRMWRNLMGAENFDTAIRSYLQQYHLTNTVP---YNLF 463
            :|   ::.|:||...|..::|.|||||:.|.|:.:.|:.|...|..|||:|...||..   :|..
Mouse   410 TP---VENPAQIREMFDDVSYEKGACILNMLRDYLSADTFKRGIVQYLQKYSYKNTKNEDLWNSM 471

  Fly   464 YHL---------------------FEHWPKNQDVDLVDFLTDYTEQVGYPMIIVKALQGNKVVTV 507
            .|:                     ..|| :.:.||:...:..:|.|.|:|:|.:.....|  |.:
Mouse   472 MHICPTDGTQTMDGFCSRSQHSSSTSHW-RQEVVDVKTMMNTWTLQKGFPLITITVSGRN--VHM 533

  Fly   508 EQSRFLLNKDDGSNATLKYTVPITFTTNLERDFYNLTPYKYLHKT-VNVLWLDFTSPIDWILFNL 571
            :|..::...:........:.||:||.|: :.|    :..::|.|| .:||.|  ...:.||.||:
Mouse   534 KQEHYMKGSERFPETGYLWHVPLTFITS-KSD----SVQRFLLKTKTDVLIL--PEAVQWIKFNV 591

  Fly   572 RQSNYQRVFYDD---TLREGLLLAISATNHSGIPVENRAQIIDDLFNFAQAQYVDYADVFRFLEY 633
            ..:.|..|.|.|   ....|||    ...|:.|...:||.:|::.|.....:.:..........|
Mouse   592 GMNGYYIVHYADDGWASLSGLL----KEAHTTISSNDRASLINNAFQLVSIEKLSIEKALDLTLY 652

  Fly   634 LAKEVEYVPWYAVYENLN-------TVAKRLTPEQLPDFRIYLSSITAAVFEKLGVGWNAQDTPL 691
            |..|.|.:|   :::.||       .:.||...|....|:.:|..:...:.:|  ..|..:.:..
Mouse   653 LKNETEIMP---IFQALNELIPMYKLMEKRDMIEVETQFKDFLLKLLKDLIDK--QTWTDEGSVS 712

  Fly   692 DVANRNKLIKWLCRYQASNCRPKVNVQF-----VTGH-EVPSPDYRETFYCAASGADYNSYTMLW 750
            :...|::|:...|......|..:....|     ..|: .:|.......|...|...:  .:..|:
Mouse   713 ERMLRSQLLLLACVRNYQPCVQRAERYFREWKSSNGNMSIPIDVTLAVFAVGAQNTE--GWDFLY 775

  Fly   751 GQYYLENRTSEKNMLWAAISCTRDYE-------THYHKMIISGTESVEQKKIGIARMYEENPDLV 808
            .:|.....::||:.:..::..::|.|       ..:...||...|...     |..:...||...
Mouse   776 SKYQSSLSSTEKSQIEFSLCTSKDPEKLQWLLDQSFKGEIIKTQEFPH-----ILTLIGRNPVGY 835

  Fly   809 QAIFEMITENIMELAYNFQSWSDT-AEVINDMAEYFTTREQQQLLKEFYYSNHQFFGESEELLSK 872
            ...::.:.||..:|...|:..|.: |.::....:.|:||.:.:.:|.| :|:.:..|.....:.:
Mouse   836 PLAWKFLRENWNKLVQKFELGSSSIAHMVMGTTDQFSTRARLEEVKGF-FSSLKENGSQLRCVQQ 899

  Fly   873 SLVTVEKNLNWAETHLEGLVKYL 895
            ::.|:|:|:.|.:.:.:.:..:|
Mouse   900 TIETIEENIRWMDKNFDKIRLWL 922

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42335	NP_732655.3	Peptidase_M1	26..425	CDD:279741	118/412 (29%)
		M1_APN_2	34..492	CDD:189008	140/495 (28%)
		ERAP1_C	567..874	CDD:288671	64/330 (19%)
Erap1	NP_109636.1	M1_APN-Q_like	50..515	CDD:341064	137/490 (28%)
		Substrate binding. /evidence=ECO:0000250	306..310		1/3 (33%)
		ERAP1_C	586..905	CDD:403137	66/335 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.020