Protein Alignment CG42335 and Erap1

DIOPT Version :10

• Sequence 1: NP_732655.3
• Gene: CG42335 / 42558
• FlyBaseID: FBgn0259237
• Length: 924
• Species: Drosophila melanogaster
• Sequence 2: XP_006231762.1
• Gene: Erap1 / 80897
• RGDID: 708542
• Length: 954
• Species: Rattus norvegicus
• Alignment Length: 971
• Identity: 235/971 - (24%)
• Similarity: 422/971 - (43%)
• Gaps: 150/971 - (15%)

  Fly    20 TNAADY-----RLEGSVVPSHYNLTIGVLRNSVEPTIFDGEVSITLRVVGTLEVQQIILHADTLD 79
            :|.|.:     ||...:.|.||:|   ::..::....|.|:..:.:.|  :.....||:|:..|.
  Rat    31 SNGASFLWNNMRLPEYITPIHYDL---MIHANLSTLTFWGKTEVEITV--SQPTSTIIMHSHQLQ 90

  Fly    80 ITECWLLDAAGAQVEAIDISRLIYEAATQQVRVPLTEAAQP---GKNYTLGFKYTGHIRTDMAGF 141
            |::..|...|...:....:..:.| :|.:||.: ||  |||   |..||:...|..::..:..||
  Rat    91 ISKATLRRGAEEMLPEEPLKLMEY-SAHEQVAL-LT--AQPLLAGSVYTVIITYAANLSENFHGF 151

  Fly   142 FSASYVERDTNVTRWLALTQMQRINARLVLPCFDEPALKAQFQLQIVRPNGYQSIANTKLKETKA 206
            :.::|..:: ...|.||.||.:...||:..||||||||||.|.::|.|...:.:|:|..|.::..
  Rat   152 YKSTYRTQE-GERRILAATQFEPTAARMAFPCFDEPALKASFSIKIKRDPRHLAISNMPLVKSVT 215

  Fly   207 LSQDRFVDHFKETPVMSTYLLAFMVANYSARGNES----EFAVLTRPEFYDNTEFSYHVGQQVVS 267
            :::....|||..|..|||||:||:::::.:....:    :.:|...|:..:..:::......::.
  Rat   216 VAEGLIEDHFDITVKMSTYLVAFIISDFKSVSKMTKSGVKVSVYAVPDKINQADYALDAAVTLLE 280

  Fly   268 AYGELFQSPYAELGNDVLQYASSPRFPHNGMENWGLIIYSDDVLIQEPGYSDDWSDKEFAIRIIA 332
            .|.:.|..||.....|:   |:.|.|....||||||..|.:..|:.:...|.. |.|......::
  Rat   281 FYEDYFSIPYPLPKQDL---AAIPDFQSGAMENWGLTTYRESALLYDKEKSSA-SSKLGITMTVS 341

  Fly   333 HETSHMWFGDSVTFSWWSYFWLNEAFARYYEYFMAHQLYPDYHL-----------DEQFVVRQM- 385
            ||.:|.|||:.||..||:..||||.||::.|:......:|:..:           .|....|.|
  Rat   342 HELAHQWFGNLVTMEWWNDLWLNEGFAKFMEFVSVTVTHPELKVMQILTANHQNEPEDLSGRAME 406

  Fly   386 ----QLIFG-------TDAQNGTQPMTSPESEIQTPSQIAYKFSGIAYAKGACIVRMWRNLMGAE 439
                :..||       .||.|.:.|:::|   ::.|:||...|..::|.|||||:.|.|:.:.|:
  Rat   407 RTEEEYFFGKCFNAMEVDALNSSHPVSTP---VENPAQIREMFDEVSYEKGACILNMLRDYLSAD 468

  Fly   440 NFDTAIRSYLQQYHLTNTVP---YNLFYHL---------------------FEHWPKNQDVDLVD 480
            .|...|..|||:|...||..   :|...|:                     ..|| :.:.:|:..
  Rat   469 TFKRGIVQYLQKYSYKNTKNEDLWNSMMHICPTDGTQTMDGFCSRNQHSSSTSHW-RQEVIDIKS 532

  Fly   481 FLTDYTEQVGYPMIIVKALQGNKVVTVEQSRFLLNKDDGSNATLKYTVPITFTTNLERDFYNLTP 545
            .:..:|.|.|:|:|.:.....|  |.::|..::...:........:.||:||.|: :.|    :.
  Rat   533 MMNTWTLQKGFPLITITVRGRN--VHLKQEHYMKGSECFPETGSLWHVPLTFITS-KSD----SV 590

  Fly   546 YKYLHKT-VNVLWLDFTSPIDWILFNLRQSNYQRVFYDD---TLREGLLLAISATNHSGIPVENR 606
            .::|.|| .:|:.|  ...::||.||:..:.|..|.|.|   ....|||    ...|:.|...:|
  Rat   591 QRFLLKTKTDVIIL--PEAVEWIKFNVGMNGYYIVHYGDDGWASLNGLL----KEAHTTISSNDR 649

  Fly   607 AQIIDDLFNFAQAQYVDYADVFRFLEYLAKEVEYVPWYAVYENLN-------TVAKRLTPEQLPD 664
            |.:|::.|.......:........:.||..|.|.:|   :::.||       .:.||...|....
  Rat   650 ASLINNAFQLVSIGKLSIEKALDLILYLKNETEIMP---IFQGLNELIPMYKLMEKRDMVEVETQ 711

  Fly   665 FRIYLSSITAAVFEKLGVGWNAQDTPLDVANRNKLIKWLC--RYQ--------------ASNCRP 713
            |:.:|..:...:..|  ..|..:.:..:...|::|:...|  |||              |||...
  Rat   712 FKDFLLRLLKDLINK--QTWTDEGSVSERMLRSQLLLLACVHRYQLCVQRAERYFREWKASNGNM 774

  Fly   714 KVNVQFVTGHEVPSPDYRETFYCAASGA-DYNSYTMLWGQYYLENRTSEKNMLWAAISCTRDYE- 776
            .:.:..             |....|.|| :...:..|:.:|.....::||:.:..::..::|.|
  Rat   775 SLPIDV-------------TLAVFAVGAQNTEGWDFLYSKYQSSLSSTEKSQIEFSLCISQDPEK 826

  Fly   777 ------THYHKMIISGTESVEQKKIGIARMYEENPDLVQAIFEMITENIMELAYNFQSWSDT-AE 834
                  ..:...||...|...     |..:...||......::.:.||..::...|:..|.: |.
  Rat   827 LQWLLDQSFKGEIIKTQEFPH-----ILTLIGRNPVGYPLAWKFLKENWNKIVQKFELGSSSIAH 886

  Fly   835 VINDMAEYFTTREQQQLLKEFYYSNHQFFGESEELLSKSLVTVEKNLNWAETHLEGLVKYL 895
            ::......|:||.:.:.:|.| :|:.:..|.....:.:::.|:|:|:.|.:.:.:.:..:|
  Rat   887 MVMGTTNQFSTRARLEEVKGF-FSSLKKNGSQLRCVQQTIETIEENIRWMDKNFDKIRLWL 946

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42335	NP_732655.3	M1_APN-Q_like	34..487	CDD:341064	138/506 (27%)
		ERAP1_C	566..878	CDD:463368	69/346 (20%)
Erap1	XP_006231762.1	M1_APN-Q_like	50..539	CDD:341064	138/506 (27%)
		ERAP1_C	610..929	CDD:463368	69/346 (20%)