Protein Alignment CG42335 and ERAP2

DIOPT Version :10

• Sequence 1: NP_732655.3
• Gene: CG42335 / 42558
• FlyBaseID: FBgn0259237
• Length: 924
• Species: Drosophila melanogaster
• Sequence 2: NP_071745.1
• Gene: ERAP2 / 64167
• HGNCID: 29499
• Length: 960
• Species: Homo sapiens
• Alignment Length: 992
• Identity: 251/992 - (25%)
• Similarity: 444/992 - (44%)
• Gaps: 152/992 - (15%)

  Fly     4 SIFRAFWLLCSLL--ICV----------------------TNA-----ADYRLEGSVVPSHYNLT 39
            :|.|.|:.|.::|  ||:                      ||.     .:.||...|:|.||:|
Human    17 NIHRGFYCLTAILPQICICSQFSVPSSYHFTEDPGAFPVATNGERFPWQELRLPSVVIPLHYDL- 80

  Fly    40 IGVLRNSVEP--TIFDGEVSITLRVVGTLEVQQIILHADTLDITECWLLDAAGAQVEAIDISR-- 100
                  .|.|  |..|...|..:.|:.:...|.||||:..|:||        .|.:::.:.||
Human    81 ------FVHPNLTSLDFVASEKIEVLVSNATQFIILHSKDLEIT--------NATLQSEEDSRYM 131

  Fly   101 -------LIYEAATQQVRVPLTEAAQPGKNYTLGFKYTGHIRTDMAGFFSASYVERDTNVTRWLA 158
                   ::...|.:|:.:.:.|...|...|.:...:...:.....||:.::| ......||.||
Human   132 KPGKELKVLSYPAHEQIALLVPEKLTPHLKYYVAMDFQAKLGDGFEGFYKSTY-RTLGGETRILA 195

  Fly   159 LTQMQRINARLVLPCFDEPALKAQFQLQIVRPNGYQSIANTKLKETKALSQDRFVDHFKETPVMS 223
            :|..:...||:..||||||..||.|.::|.|.:.:.:::|....:|..|......|||:.|..||
Human   196 VTDFEPTQARMAFPCFDEPLFKANFSIKIRRESRHIALSNMPKVKTIELEGGLLEDHFETTVKMS 260

  Fly   224 TYLLAFMVANY-SARGNES---EFAVLTRPEFYDNTEFSYHVGQQVVSAYGELFQSPYAELGNDV 284
            |||:|::|.:: |..|..|   :.::...|:..:.|.::.....:::..|.:.|...|.....|:
Human   261 TYLVAYIVCDFHSLSGFTSSGVKVSIYASPDKRNQTHYALQASLKLLDFYEKYFDIYYPLSKLDL 325

  Fly   285 LQYASSPRFPHNGMENWGLIIYSDDVLIQEPGYSDDWSDKEFAIRIIAHETSHMWFGDSVTFSWW 349
            :   :.|.|....|||||||.|.:..|:.:|..|.. |||.:..|:||||.:|.|||:.||..||
Human   326 I---AIPDFAPGAMENWGLITYRETSLLFDPKTSSA-SDKLWVTRVIAHELAHQWFGNLVTMEWW 386

  Fly   350 SYFWLNEAFARYYEYFMAHQLYPDYHLDEQFVVRQMQLIFGTDAQNGTQPMTSPESEIQTPSQIA 414
            :..||.|.||:|.|....:..||:...|:.|:....::| ..|:.|.::|::.|   .:||:||.
Human   387 NDIWLKEGFAKYMELIAVNATYPELQFDDYFLNVCFEVI-TKDSLNSSRPISKP---AETPTQIQ 447

  Fly   415 YKFSGIAYAKGACIVRMWRNLMGAENFDTAIRSYLQQYHLTNTVPYNLFYHLFEHW--------- 470
            ..|..::|.|||||:.|.::.:|.|.|...|..||:::...|....:|:..|....
Human   448 EMFDEVSYNKGACILNMLKDFLGEEKFQKGIIQYLKKFSYRNAKNDDLWSSLSNSCLESDFTSGG 512

  Fly   471 -----PK---------NQDVDLVDFLTDYTEQVGYPMIIVKALQGNKVVTVEQSRFL--LNKDDG 519
                 ||         .::.::.:.:|.:|.|.|.|:::||  |....:.::|.|||  :.::|.
Human   513 VCHSDPKMTSNMLAFLGENAEVKEMMTTWTLQKGIPLLVVK--QDGCSLRLQQERFLQGVFQEDP 575

  Fly   520 SNATLK----YTVPITFTTNLERDFYNLTPYKYLHKTV---NVLWLDFTSPIDWILFNLRQSNYQ 577
            ....|:    :.:|:|::|:..         ..:|:.:   ....||......|:.||:..:.|.
Human   576 EWRALQERYLWHIPLTYSTSSS---------NVIHRHILKSKTDTLDLPEKTSWVKFNVDSNGYY 631

  Fly   578 RVFYDDTLREGLLLAISATNHSGIPVENRAQIIDDLFNFAQA--QYVDYA-DVFRFLEY------ 633
            .|.|:....:.|:..:: .||:.:..::|..:|.|:|....|  ..:|.| |:..:|::
Human   632 IVHYEGHGWDQLITQLN-QNHTLLRPKDRVGLIHDVFQLVGAGRLTLDKALDMTYYLQHETSSPA 695

  Fly   634 LAKEVEYV-PWYAVYE--NLNTVAKRLTPEQLPDFRIYLSSITAAVFEKLGVGWNAQDTPLDVAN 695
            |.:.:.|: .:|.:.:  |::.:::.|        :.||......|.::  ..|:.:.:..|...
Human   696 LLEGLSYLESFYHMMDRRNISDISENL--------KRYLLQYFKPVIDR--QSWSDKGSVWDRML 750

  Fly   696 RNKLIKWLCRYQASNCRPKVNVQFVTGHE------VPSPDYRETFYC--AASGADYNSYTMLWGQ 752
            |:.|:|..|....:.|..|....|....|      :|: |..:..|.  |.:.|.:|   .|..|
Human   751 RSALLKLACDLNHAPCIQKAAELFSQWMESSGKLNIPT-DVLKIVYSVGAQTTAGWN---YLLEQ 811

  Fly   753 YYLENRTSEKNMLWAAISCTRDYETHYHKMIISGTESVEQKKIGIARMYE---ENPDLVQAIFEM 814
            |.|...::|:|.:..|:| |..::....|:|..|.|....|...:|.:..   ..|...|..::.
Human   812 YELSMSSAEQNKILYALS-TSKHQEKLLKLIELGMEGKVIKTQNLAALLHAIARRPKGQQLAWDF 875

  Fly   815 ITENIMELAYNFQSWS-DTAEVINDMAEYFTTREQQQLLKEFYYSNHQFFGESEELLSKSLVTVE 878
            :.||...|...|...| |...:|:....:|:::::.|.:|.|:.| .:..|...::....|.|:.
Human   876 VRENWTHLLKKFDLGSYDIRMIISGTTAHFSSKDKLQEVKLFFES-LEAQGSHLDIFQTVLETIT 939

  Fly   879 KNLNWAETHLEGLVKYL 895
            ||:.|.|.:|..|..:|
Human   940 KNIKWLEKNLPTLRTWL 956

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42335	NP_732655.3	M1_APN-Q_like	34..487	CDD:341064	138/490 (28%)
		ERAP1_C	566..878	CDD:463368	74/335 (22%)
ERAP2	NP_071745.1	M1_APN-Q_like	76..543	CDD:341064	138/490 (28%)
		ERAP1_C	620..938	CDD:463368	73/334 (22%)