DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42335 and ERAP2

DIOPT Version :9

Sequence 1:	NP_732655.3	Gene:	CG42335 / 42558	FlyBaseID:	FBgn0259237	Length:	924	Species:	Drosophila melanogaster
Sequence 2:	NP_001123612.1	Gene:	ERAP2 / 64167	HGNCID:	29499	Length:	960	Species:	Homo sapiens

Alignment Length:	992	Identity:	251/992 - (25%)
Similarity:	444/992 - (44%)	Gaps:	152/992 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 SIFRAFWLLCSLL--ICV----------------------TNA-----ADYRLEGSVVPSHYNLT 39
            :|.|.|:.|.::|  ||:                      ||.     .:.||...|:|.||:|
Human    17 NIHRGFYCLTAILPQICICSQFSVPSSYHFTEDPGAFPVATNGERFPWQELRLPSVVIPLHYDL- 80

  Fly    40 IGVLRNSVEP--TIFDGEVSITLRVVGTLEVQQIILHADTLDITECWLLDAAGAQVEAIDISR-- 100
                  .|.|  |..|...|..:.|:.:...|.||||:..|:||        .|.:::.:.||
Human    81 ------FVHPNLTSLDFVASEKIEVLVSNATQFIILHSKDLEIT--------NATLQSEEDSRYM 131

  Fly   101 -------LIYEAATQQVRVPLTEAAQPGKNYTLGFKYTGHIRTDMAGFFSASYVERDTNVTRWLA 158
                   ::...|.:|:.:.:.|...|...|.:...:...:.....||:.::| ......||.||
Human   132 KPGKELKVLSYPAHEQIALLVPEKLTPHLKYYVAMDFQAKLGDGFEGFYKSTY-RTLGGETRILA 195

  Fly   159 LTQMQRINARLVLPCFDEPALKAQFQLQIVRPNGYQSIANTKLKETKALSQDRFVDHFKETPVMS 223
            :|..:...||:..||||||..||.|.::|.|.:.:.:::|....:|..|......|||:.|..||
Human   196 VTDFEPTQARMAFPCFDEPLFKANFSIKIRRESRHIALSNMPKVKTIELEGGLLEDHFETTVKMS 260

  Fly   224 TYLLAFMVANY-SARGNES---EFAVLTRPEFYDNTEFSYHVGQQVVSAYGELFQSPYAELGNDV 284
            |||:|::|.:: |..|..|   :.::...|:..:.|.::.....:::..|.:.|...|.....|:
Human   261 TYLVAYIVCDFHSLSGFTSSGVKVSIYASPDKRNQTHYALQASLKLLDFYEKYFDIYYPLSKLDL 325

  Fly   285 LQYASSPRFPHNGMENWGLIIYSDDVLIQEPGYSDDWSDKEFAIRIIAHETSHMWFGDSVTFSWW 349
            :   :.|.|....|||||||.|.:..|:.:|..|.. |||.:..|:||||.:|.|||:.||..||
Human   326 I---AIPDFAPGAMENWGLITYRETSLLFDPKTSSA-SDKLWVTRVIAHELAHQWFGNLVTMEWW 386

  Fly   350 SYFWLNEAFARYYEYFMAHQLYPDYHLDEQFVVRQMQLIFGTDAQNGTQPMTSPESEIQTPSQIA 414
            :..||.|.||:|.|....:..||:...|:.|:....::| ..|:.|.::|::.|   .:||:||.
Human   387 NDIWLKEGFAKYMELIAVNATYPELQFDDYFLNVCFEVI-TKDSLNSSRPISKP---AETPTQIQ 447

  Fly   415 YKFSGIAYAKGACIVRMWRNLMGAENFDTAIRSYLQQYHLTNTVPYNLFYHLFEHW--------- 470
            ..|..::|.|||||:.|.::.:|.|.|...|..||:::...|....:|:..|....
Human   448 EMFDEVSYNKGACILNMLKDFLGEEKFQKGIIQYLKKFSYRNAKNDDLWSSLSNSCLESDFTSGG 512

  Fly   471 -----PK---------NQDVDLVDFLTDYTEQVGYPMIIVKALQGNKVVTVEQSRFL--LNKDDG 519
                 ||         .::.::.:.:|.:|.|.|.|:::||  |....:.::|.|||  :.::|.
Human   513 VCHSDPKMTSNMLAFLGENAEVKEMMTTWTLQKGIPLLVVK--QDGCSLRLQQERFLQGVFQEDP 575

  Fly   520 SNATLK----YTVPITFTTNLERDFYNLTPYKYLHKTV---NVLWLDFTSPIDWILFNLRQSNYQ 577
            ....|:    :.:|:|::|:..         ..:|:.:   ....||......|:.||:..:.|.
Human   576 EWRALQERYLWHIPLTYSTSSS---------NVIHRHILKSKTDTLDLPEKTSWVKFNVDSNGYY 631

  Fly   578 RVFYDDTLREGLLLAISATNHSGIPVENRAQIIDDLFNFAQA--QYVDYA-DVFRFLEY------ 633
            .|.|:....:.|:..:: .||:.:..::|..:|.|:|....|  ..:|.| |:..:|::
Human   632 IVHYEGHGWDQLITQLN-QNHTLLRPKDRVGLIHDVFQLVGAGRLTLDKALDMTYYLQHETSSPA 695

  Fly   634 LAKEVEYV-PWYAVYE--NLNTVAKRLTPEQLPDFRIYLSSITAAVFEKLGVGWNAQDTPLDVAN 695
            |.:.:.|: .:|.:.:  |::.:::.|        :.||......|.::  ..|:.:.:..|...
Human   696 LLEGLSYLESFYHMMDRRNISDISENL--------KRYLLQYFKPVIDR--QSWSDKGSVWDRML 750

  Fly   696 RNKLIKWLCRYQASNCRPKVNVQFVTGHE------VPSPDYRETFYC--AASGADYNSYTMLWGQ 752
            |:.|:|..|....:.|..|....|....|      :|: |..:..|.  |.:.|.:|   .|..|
Human   751 RSALLKLACDLNHAPCIQKAAELFSQWMESSGKLNIPT-DVLKIVYSVGAQTTAGWN---YLLEQ 811

  Fly   753 YYLENRTSEKNMLWAAISCTRDYETHYHKMIISGTESVEQKKIGIARMYE---ENPDLVQAIFEM 814
            |.|...::|:|.:..|:| |..::....|:|..|.|....|...:|.:..   ..|...|..::.
Human   812 YELSMSSAEQNKILYALS-TSKHQEKLLKLIELGMEGKVIKTQNLAALLHAIARRPKGQQLAWDF 875

  Fly   815 ITENIMELAYNFQSWS-DTAEVINDMAEYFTTREQQQLLKEFYYSNHQFFGESEELLSKSLVTVE 878
            :.||...|...|...| |...:|:....:|:::::.|.:|.|:.| .:..|...::....|.|:.
Human   876 VRENWTHLLKKFDLGSYDIRMIISGTTAHFSSKDKLQEVKLFFES-LEAQGSHLDIFQTVLETIT 939

  Fly   879 KNLNWAETHLEGLVKYL 895
            ||:.|.|.:|..|..:|
Human   940 KNIKWLEKNLPTLRTWL 956

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42335	NP_732655.3	Peptidase_M1	26..425	CDD:279741	124/413 (30%)
		M1_APN_2	34..492	CDD:189008	141/495 (28%)
		ERAP1_C	567..874	CDD:288671	71/330 (22%)
ERAP2	NP_001123612.1	Peptidase_M1	68..458	CDD:279741	124/413 (30%)
		M1_APN_2	76..548	CDD:189008	141/495 (28%)
		Substrate binding	334..338		1/3 (33%)
		ERAP1_C	621..938	CDD:288671	72/333 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	5.020