DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42335 and Enpep

DIOPT Version :9

Sequence 1:	NP_732655.3	Gene:	CG42335 / 42558	FlyBaseID:	FBgn0259237	Length:	924	Species:	Drosophila melanogaster
Sequence 2:	NP_071587.2	Gene:	Enpep / 64017	RGDID:	621228	Length:	945	Species:	Rattus norvegicus

Alignment Length:	927	Identity:	238/927 - (25%)
Similarity:	407/927 - (43%)	Gaps:	124/927 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 DYRLEGSVVPSHYNLTIGVLRNSVEPTIFDGEVSITLRVVGTLEVQQIILHADTLDITEC-WLLD 87
            ::||...:.|.||:|.:.||   :|...:.|.|||::.:  :.:.:.:.||.....||:. .|..
  Rat    82 NFRLPDFIQPVHYDLEVKVL---MEEDRYTGIVSISVNL--SKDTRDLWLHIRETRITKLPELRR 141

  Fly    88 AAGAQVEAIDISRLIYEAATQQVRVPLTE---AAQPGKN-YTLGFKYTGHIRTDMAGFFSASYVE 148
            .:|.||..    |..:|...|:..|...|   ||..|.: |.|..::.|.:...:.||:..:|.|
  Rat   142 PSGEQVPI----RRCFEYKKQEYVVIQAEEDLAATSGDSVYRLTIEFEGWLNGSLVGFYRTTYTE 202

  Fly   149 RDTNVTRWLALTQMQRINARLVLPCFDEPALKAQFQLQIVRPNGYQSIANTKLKETKALSQDRFV 213
              ...|:.:|.|..:..:||...||||||..||.:.:.::.|..|.:::|..:::.:.|..|...
  Rat   203 --DGQTKSIAATDHEPTDARKSFPCFDEPNKKATYNISLIHPKEYSALSNMPVEKEETLDNDWKK 265

  Fly   214 DHFKETPVMSTYLLAFMVANYSARGNESE----FAVLTRPEFYDNTEFSYHVGQQVVSAYGELFQ 274
            ..|.::..|||||:.|.|..:::....|.    ..|..:|......|::.::.:.|...:.:.|.
  Rat   266 TTFMKSVPMSTYLVCFAVHQFTSIQRTSRSGKPLTVYVQPNQKQTAEYAANITKAVFDFFEDYFA 330

  Fly   275 SPYAELGNDVLQYASSPRFPHNGMENWGLIIYSDDVLIQEPGYSDDWSDKEFAIRIIAHETSHMW 339
            ..|:   ...|...:.|.|....||||||:.|.:..|:.:|..|.. |:::....::|||..|.|
  Rat   331 MEYS---LPKLDKIAIPDFGTGAMENWGLVTYRETNLLYDPLLSAS-SNQQRVASVVAHELVHQW 391

  Fly   340 FGDSVTFSWWSYFWLNEAFARYYEYFMAHQLYPDYHLDEQFVVRQMQLIFGTDAQNGTQPMTSPE 404
            ||:.||..||...||||.||.::|:...:....|:.:..|.::..:..:...|:...:.|:.
  Rat   392 FGNIVTMDWWDDLWLNEGFASFFEFLGVNHAEADWQMLSQVLLEDVLPVQEDDSLMSSHPVV--- 453

  Fly   405 SEIQTPSQIAYKFSGIAYAKGACIVRMWRNLMGAENFDTAIRSYLQQYHLTNTVPYNLFYHLFEH 469
            ..:.||::|...|.||:|:|||.|:||.::.:..|.|....:.||:.:...|....: |:...|.
  Rat   454 VTVSTPAEITSVFDGISYSKGASILRMLQDWITPEKFQKGCQIYLENFKFKNAKTSD-FWDSLEK 517

  Fly   470 WPKNQDVDLVDFLTDYTEQVGYPMIIVKALQGNKVVTVEQSRFLLN-KDDGSN--ATLKYT--VP 529
             ..||.|.  :.:..:|.|:|||::.|...|     .|.|.||||: |.|.|.  :.|.||  :|
  Rat   518 -ASNQPVK--EVMDTWTSQMGYPVVTVSGKQ-----NVTQKRFLLDYKADPSQPPSALGYTWNIP 574

  Fly   530 ITFTTNLERDFYNLTPYKYLHK---TVNVLWLDFTSPIDWILFNLRQSNYQRVFYD----DTLRE 587
            |.:|.|...   |:|.|...::   |:|.    ..|...::..|.....:.||.|:    |.:.|
  Rat   575 IKWTENGNS---NITVYYRSNREGITLNA----NLSGDGFLKINPDHIGFYRVNYEAETWDWIAE 632

  Fly   588 GLLLAISATNHSGIPVENRAQIIDDLFNFAQAQYVDYADVFRFLEYLAKEVEYVPWYAVYENLNT 652
            .|     ::||......:|:..|||.|..|:||.:||........||..|.:::||..|...::.
  Rat   633 TL-----SSNHMNFSSADRSSFIDDAFALARAQLLDYEKALNLTRYLTSEKDFLPWERVISAVSY 692

  Fly   653 VAKRLTP--EQLPDFRIYLSSITAAVFEKLGVGWNAQDTPLDVAN--RNKLIKWLCRYQASNCRP 713
            :......  |..|....|..|....:.:.|  ||  |||...:..  |..::.:.|:..|.....
  Rat   693 IISMFEDDRELYPLIETYFRSQVKPIADSL--GW--QDTGSHITKLLRASVLGFACKMGAGEALG 753

  Fly   714 KVNVQF---VTGHE-VPSP----DYRETFYCAASGADYNSYTMLWGQYYLENRTSEKNMLWAAIS 770
            ..:..|   :.|:| :|..    .||.....:.:.|.:| ||:  .||...:...||..|...::
  Rat   754 NASQLFEAWLKGNESIPVNLRLLVYRYGMQNSGNEAAWN-YTL--EQYQKTSLAQEKEKLLYGLA 815

  Fly   771 CTRDYETHYHKMIISGTESVEQKKIGIARMYE--ENPDLV--QAIFEMI-----TENIMELAYNF 826
            ..:|...                   :||..|  ::|:::  |.:|.:|     ......:|:|:
  Rat   816 SVKDVTL-------------------LARYLEMLKDPNIIKTQDVFTVIRYISYNSYGKSMAWNW 861

  Fly   827 --QSWSDTAE--VIND--------MAEYFTTREQQQLLKEFY--YSNHQFFGESEELLSKSLVTV 877
              .:|.....  .|||        :||.|.|..|...::.|:  |.|   .|...:...:.|.||
  Rat   862 IQLNWDYLVNRFTINDRYLGRIVTIAEPFNTELQLWQMQSFFAKYPN---AGAGAKPREQVLETV 923

  Fly   878 EKNLNWAETHLEGLVKY 894
            :.|:.|.:.:.:.:.::
  Rat   924 KNNIEWLKLNRKSISEW 940

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42335	NP_732655.3	Peptidase_M1	26..425	CDD:279741	112/407 (28%)
		M1_APN_2	34..492	CDD:189008	128/466 (27%)
		ERAP1_C	567..874	CDD:288671	76/345 (22%)
Enpep	NP_071587.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	45..77
		Peptidase_M1	84..474	CDD:279741	112/407 (28%)
		M1_APN_2	92..537	CDD:189008	128/466 (27%)
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:Q07075	349..353		1/3 (33%)
		ERAP1_C	608..922	CDD:288671	77/347 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	6.020